A Microtubule-Based Microbial Pattern Recognition System
Our work has revealed polymorphisms that show that microbial defense systems could be linked to human autoimmune diseases.
Development of Mucosal Immunity
We study human genetic diversity associated with inflammatory bowel diseases to understand the principal mechanisms of mucosal immunity that control the intestinal barrier function and the microbiome.
GEF-H1 Regulation of Anti-tumor Immunity
Dendritic cell targeting through the GEF-H1 immune pathway may be utilized to overcome the immune tolerant tumor environment and improve the utility of current immune checkpoint blockade and personalized cancer vaccinations.
Microbial Transcriptional Regulators Control Mucosal Host Defenses
The identification of the STING-IRF1 signaling axis for adaptive host defense control will aid in the elucidation of disease mechanisms that are initiated by cytosolic host or pathogen DNA processing and recognition.