News

Kennady Knox Graduation

May 2024

Dr. Kennady Knox Graduation!

Yan lab's first MD/PhD student!

Yan lab graduates

April 2024

Yan Lab Graduate Student Reunion!

Very exciting to see past and current graduate students together!

Zhen Cong Qual 2023

April 2023

Congratulations to graduate student Zhen Tang and Cong Xing for passing Qualifying Exam!

Science Immunology Cover

June 2022

Science Immunology Cover Story on our RNA Exosome paper

We found that the SKIV2L RNA exosome is essential for V(D)J recombination and the pro–B cell to large pre–B cell transition during early B cell development.

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Nan and Xintao

May 2022

Dr. Xintao Tu Graduation!

Vlad Graduation

September 2018

Dr. Vlad Pokatayev Graduation!

Charles graduation

May 2018

Dr. Charles Fermaintt Graduation!

Emika Aroh Graduation

May 2017

Dr. Emika Aroh Graduation!

March 2017

Tomomi Sakai publishes in Autoimmunity

Sakai T, Miyazaki T, Shin DM, Kim YS, Qi CF, Fariss R, Munasinghe J, Wang H, Kovalchuk AL, Kothari PH, Fermaintt CS, Atkinson JP, Perrino FW, Yan N, Morse HC 3rd. Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism. J Autoimmun. 2017 Mar 18. pii: S0896-8411(17)30024-0. doi: 10.1016/j.jaut.2017.03.001. [Epub ahead of print]

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March 2017

Martin and Charles’s paper on TREX1 mitotic phosphorylation is published in Cell Reports

Kucej M, Fermaintt CS, Yang K, Irizarry-Caro RA, Yan N. Mitotic Phosphorylation of TREX1 C Terminus Disrupts TREX1 Regulation of the Oligosaccharyltransferase Complex . Cell Rep. 2017 Mar 14;18(11):2600-2607. doi: 10.1016/j.celrep.2017.02.051.

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January 2017

Maroof and Vijay’s paper on mTORC1 published in PNAS

Hasan M, Gonugunta VK, Dobbs N, Ali A, Palchik G, Calvaruso MA, DeBerardinis RJ, Yan N. Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism. PNAS USA. 2017 Jan 24;114(4):746-751. doi: 10.1073/pnas.1611113114. Epub 2017 Jan 9.

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March 2016

Vlad Pokatayev publishes in Journal of Experimental Medicine

Pokatayev V, Hasin N, Chon H, Cerritelli SM, Sakhuja K, Ward JM, Morris HD, Yan N, Crouch RJ. RNase H2 catalytic core Aicardi-Goutières syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice . J Exp Med. 2016 Mar 7; 213(3):329-36. doi: 10.1084/jem.20151464. Epub 2016 Feb 15.

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February 2016

RNase H2 Regulates cGAS-STING

RNase H2 acts to prevent activation of the cGAS-STING DNA-sensing pathway.

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November 2015

Maroof Hasan publishes in J Immunology

Hasan M, Dobbs N, Khan S, White MA, Wakeland EK, Li QZ, Yan N. Cutting Edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in Mice. J Immunol. 2015 Nov 15;195(10):4573-7. doi: 10.4049/jimmunol.1500162. Epub 2015 Oct 2.

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August 2015

Maroof Hasan and Charles Fermaintt have a paper published in Immunity

Hasan M, Fermaintt CS, Gao N, Sakai T<, Miyazaki T, Jiang S, Li QZ,, Atkinson JP, Morse HC 3rd, Lehrman MA, Yan N.Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation.Immunity. 2015 Sep 15;43(3):463-74. doi: 10.1016/j.immuni.2015.07.022. Epub 2015 Aug 25.

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August 2015

Nicole Dobb’s research on STING published in Cell Host & Microbes

Dobbs N, Burnaevskiy N,, Chen D, Gonugunta VK, Alto NM, Yan N. STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease, Cell Host Microbe. 2015 Aug 12;18(2):157-68. doi: 10.1016/j.chom.2015.07.001. Epub 2015 Jul 30.

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May 2013

Charles Fermaintt Receives NSF Grant

Congratulations, Charles!

December 2012

Maroof’s paper on TREX1 is published in Nature Immunology

Hasan M, Koch J, Rakheja D, Pattnaik AK, Brugarolas J, Dozmorov I, Levine B, Wakeland EK, Lee-Kirsch MA, Yan N. Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes. Nat Immunol. 2013 Jan;14(1):61-71. doi: 10.1038/ni.2475.

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