The Stuve laboratory is studying the differential molecular requirements for bone-marrow-derived leukocytes to cross the blood-brain barrier or other biological barriers that provide immune privilege for the central nervous system (CNS). He is also exploring molecular and cellular differences between bone-marrow-derived myeloid cells subsets and CNS-intrinsic microglia, and the potential pathogenic role of innate immune cells in early and late MS. Furthermore, Dr. Stuve's research interests include molecular and cellular markers of autoimmunity, and experimental therapies for autoimmune disorders, and he has numerous ongoing collaborations with national and international investigators.