Publications for Orhan Oz, M.D., Ph.D.

1 Oz OK, Campbell A, Tao TW. Reduced Cell Adhesion to Fibronectin and Laminin is Associated with Altered Glycosylation of β1 Integrins in a Low Metastatic Glycosylation Mutant. Int J Cancer. 1989 Aug 15;44(2):343-7. PMID: 2788145

2 Ayanoglu E, Rizzolio M, Beaulieu S, Roberts J, Öz O, Djerassi C. Covalently Bound Fatty Acids in Membrane Proteins of Some Sponges. Comp Biochem and Physiol 1990; 96B(3): 597-603. doi:10.1016/0305-0491(90)90063-Y.

3 Parikh VS, Tucker PW, Öz OK. Novel Metallothionein Conjugates for Imaging and Therapy of Tumors. Tumor Targeting 1995; 1:1-3.

4 Bordlee RP, Nahid E, Öz O. Thoracic Splenosis: MR Demonstration. J. Thoracic Imaging 1995; 10:146-149. PMID:7769632.

5 Öz O, Choe W, Borders L, Awad R. Normal Vasculature in Tc99m RBC labeled liver SPECT with corresponding CT: All is not tumor that is hot. Clin Nuc Med 1996; 21:809-812. PMID:8896936.

6    Mehta SS, Öz OK, Antich PP. Bone elasticity and ultrasound velocity are affected by subtle changes in the organic matrix. J Bone Miner Res. 1998 Jan;13(1):114-21. PMID:9443797

7 Choyke PL, Siegel MJ, Öz O, Sotelo-Avila C, and DeBaun MR: Nonmalignant Renal Disease in Pediatric Patients with Beckwith-Wiedeman Syndrome. Am J Roetgenol 1998; 171(3):733-737. PMID:9725306.

8 Oz OK, Zerwekh JE, Fisher C, Graves K, Nanu L, Millsaps R, Simpson ER. Bone has a Sexually Dimorphic Response to Aromatase Deficiency. J Bone Miner Res. 2000 Mar;15(3):507-14. PMID: 9443797

9 Skiest DJ, Erdman W, Chang WE, Oz OK, Ware A, Fleckenstein J. SPECT thallium-201 combined with Toxoplasma serology for the presumptive diagnosis of focal central nervous system mass lesions in patients with AIDS. J Infect. 2000 May;40(3):274-81. PMID:1090802

10 Jones ME, Thorburn AW, Britt KL, Hewitt KN, Wreford NG, Proietto J, Oz OK, Leury BJ, Robertson KM, Yao S, Simpson ER. Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity. Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12735-40. PMID:11070087

11 Oz OK, Millsaps R, Welch R, Birch J, Zerwekh JE. Expression of aromatase in the human growth plate. J Mol Endocrinol. 2001 Oct;27(2):249-53. PMID:11564607

12 Oz OK, Hirasawa G, Lawson J, Nanu L, Constantinescu A, Antich PP, Mason RP, Tsyganov E, Parkey RW, Zerwekh JE, Simpson ER. Bone phenotype of the aromatase deficient mouse. J Steroid Biochem Mol Biol. 2001 Dec;79(1-5):49-59. PMID:11850207

13 Jones ME, Thorburn AW, Britt KL, Hewitt KN, Misso ML, Wreford NG, Proietto J, Oz OK, Leury BJ, Robertson KM, Yao S, Simpson ER. Aromatase-deficient (ArKO) mice accumulate excess adipose tissue. J Steroid Biochem Mol Biol. 2001 Dec;79(1-5):3-9. PMID:11850201

14 Mathews D, Oz OK. Positron emission tomography in prostate and renal cell carcinoma. Curr Opin Urol. 2002 Sep;12(5):381-5. Review. PMID:12172424

15 McCullough LD, Blizzard K, Simpson ER, Oz OK, Hurn PD. Aromatase cytochrome P450 and extragonadal estrogen play a role in ischemic neuroprotection. J Neurosci. 2003 Sep 24;23(25):8701-5. PMID:14507969

16 Cui Y, Huang L, Elefteriou F, Yang G, Shelton JM, Giles JE, Oz OK, Pourbahrami T, Lu CY, Richardson JA, Karsenty G, Li C. Essential role of STAT3 in body weight and glucose homeostasis. Mol Cell Biol. 2004 Jan;24(1):258-69. PMID:14673160

17 Braasch DA, Paroo Z, Constantinescu A, Ren G, Oz OK, Mason RP, Corey DR. Biodistribution of phosphodiester and phosphorothioate siRNA. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1139-43. PMID:14980652

18 Holder JL Jr, Zhang L, Kublaoui BM, DiLeone RJ, Oz OK, Bair CH, Lee YH, Zinn AR. Sim1 gene dosage modulates the homeostatic feeding response to increased dietary fat in mice. Am J Physiol Endocrinol Metab. 2004 Jul;287(1):E105-13. Epub 2004 Feb 24. PMID:14982752

19 Moe OW, Zerwekh JE, Huang CL, Preisig PA, Öz OK, Pak CYC. Pathogenesis of Primary Hypercalciuria. Clinical Cases in Mineral and Bone Metabolism 2004; 1(1):13-19.

20 Coskun ZU, Stewart CE, Robinson M, Beisert G, Rivera FJ, Oz OK. Fortuitous detection of pseudoaneurysm by three-phase bone scan. Clin Nucl Med. 2005 Oct;30(10):685-7. PMID:16166844

21 Plackett TP, Oz OK, Simpson ER, Kovacs EJ. Lack of aromatase improves cell-mediated immune response after burn. Burns. 2006 Aug;32(5):577-82. Epub 2006 Jun 5. PMID:16750303

22 Tsyganov E., Anderson J, Arbique G, Constantinescu A, Jennewein M, Kulkarni P., Mason R, McColl R, Öz O, Parkey R, Richer E, Rösch F, Seliounine S, Slavine NV, Srivastava SC, Thorpe PE, Zinchenko AI, Antich PP: “UT SW Small Animal Positron Emission Imager”, IEEE Trans. Nucl. Sci., 2006; 53(5):2591-2600.

23 Shie P, Farukhi I, Hughes RS, Oz OK. Round pneumonia mimicking pulmonary malignancy on F-18 FDG PET/CT. Clin Nucl Med. 2007 Jan;32(1):55-6. PMID:17179809

24 Zerwekh JE, Oz OK. Estrogen and androgen play distinct roles in bone turnover in male mice before and after reaching sexual maturity. Bone. 2007 Feb;40(2):553. Epub 2006 Oct 4. PMID:17023225

25 Coskun ZU, Mathews D, Weatherall P, Skiest D, Oz OK. Cryptococcal lymphadenitis and massive splenomegaly in an immunocompromised patient. Clin Nucl Med. 2007 Apr;32(4):314-6. PMID:17413585

26 Zhang S, Cagatay T, Amanai M, Zhang M, Kline J, Castrillon DH, Ashfaq R, Oz OK, Wharton KA Jr. Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2. Mol Cell Biol. 2007 Jun;27(12):4454-64. Epub 2007 Apr 16. PMID:17438140

27 Oz OK, Hajibeigi A, Howard K, Cummins CL, van Abel M, Bindels RJ, Word RA, Kuro-o M, Pak CY, Zerwekh JE. Aromatase deficiency causes altered expression of molecules critical for calcium reabsorption in the kidneys of female mice . J Bone Miner Res. 2007 Dec;22(12):1893-902. PMID:17708714

28 Liu W, Hajibeigi A, Lin M, Rostollan CL, Kovacs Z, Oz OK, Sun X. An osteoclast-targeting agent for imaging and therapy of bone metastasis. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4789-93. doi: 10.1016/j.bmcl.2008.07.092. Epub 2008 Jul 27. PMID:18692394

29 Liu J, Hajibeigi A, Ren G, Lin M, Siyambalapitiyage W, Liu Z, Simpson E, Parkey RW, Sun X, Oz OK. Retention of the radiotracers 64Cu-ATSM and 64Cu-PTSM in human and murine tumors is influenced by MDR1 protein expression. J Nucl Med. 2009 Aug;50(8):1332-9. doi: 10.2967/jnumed.109.061879. Epub 2009 Jul 17. PMID:19617332

30 Moro L, Arbini AA, Hsieh JT, Ford J, Simpson ER, Hajibeigi A, Oz OK. Aromatase deficiency inhibits the permeability transition in mouse liver mitochondria. Endocrinology. 2010 Apr;151(4):1643-52. doi: 10.1210/en.2009-1450. Epub 2010 Mar 1. PMID:20194728

31 Lewis MA, Kodibagkar VD, Öz OK, Mason RP. On the potential for molecular imaging with Cerenkov luminescence. Opt Lett. 2010 Dec 1;35(23):3889-91. doi: 10.1364/OL.35.003889. PMID:21124555

32 Ford J, Hajibeigi A, Long M, Hahner L, Gore C, Hsieh JT, Clegg D, Zerwekh J, Oz OK. GPR30 deficiency causes increased bone mass, mineralization, and growth plate proliferative activity in male mice. J Bone Miner Res. 2011 Feb;26(2):298- 307. doi: 10.1002/jbmr.209. PMID:20734455

33 Yamasaki T, Tran TA, Oz OK, Raj GV, Schwarz RE, Deberardinis RJ, Zhang X, Brugarolas J. Exploring a glycolytic inhibitor for the treatment of an FH-deficient type-2 papillary RCC. Nat Rev Urol. 2011 Mar;8(3):165-71. doi: 10.1038/nrurol.2010.234. Epub 2011 Feb 8. PMID:21304509

34 Hao G, Singh AN, Oz OK, Sun X. Recent advances in copper radiopharmaceuticals. Curr Radiopharm. 2011 Apr;4(2):109- 21. Review. PMID:22191650

35 Singh AN, Liu W, Hao G, Kumar A, Gupta A, Öz OK, Hsieh JT, Sun X. Multivalent bifunctional chelator scaffolds for gallium-68 based positron emission tomography imaging probe design: signal amplification via multivalency. Bioconjug Chem. 2011 Aug 17;22(8):1650-62. doi: 10.1021/bc200227d. Epub 2011 Jul 26. PMID:21740059

36 Ford JJ, Hajibeigi A, and Öz OK. Emerging Role of GPR30/GPER1 in Skeletal Metabolism. Immun., Endoc. & Metab Agents in Med Chem. 2011; 11(4): 275-281. DOI: 10.2174/1871522211108040275

37 Hao G, Hajibeigi A, León-Rodríguez LM, Oz OK, Sun X. Peptoid-based PET imaging of vascular endothelial growth factor receptor (VEGFR) expression. Am J Nucl Med Mol Imaging. 2011;1(1):65-75. Epub 2011 Aug 1. PMID:23133797.

38 Gould-Simon A, Erdman W, Öz OK. ⁶⁷Ga uptake after cosmetic augmentation with silicone in HIV-infected patient with unexplained hypercalcemia: utility of SPECT/CT. Clin Nucl Med. 2012 Mar;37(3):298-300. doi: 10.1097/RLU.0b013e3182443e5f. PMID:22310263

39 Erdman WA, Buethe J, Bhore R, Ghayee HK, Thompson C, Maewal P, Anderson J, Klemow S, Oz OK. Indexing severity of diabetic foot infection with 99mTc-WBC SPECT/CT hybrid imaging. Diabetes Care. 2012 Sep;35(9):1826-31. doi: 10.2337/dc11-2425. Epub 2012 Jun 20. PMID:22723341

40 Zhou C, Hao G, Thomas P, Liu J, Yu M, Sun S, Öz OK, Sun X, Zheng J. Near-infrared emitting radioactive gold nanoparticles with molecular pharmacokinetics. Angew Chem Int Ed Engl. 2012 Oct 1;51(40):10118-22. doi: 10.1002/anie.201203031. Epub 2012 Sep 7. PMID:22961978

41 Hao G, Du Y, Zhou XJ, Guo J, Sun X, Mohan C, Oz OK. Serial non-invasive assessment of antibody induced nephritis in mice using positron emission tomography. PLoS One. 2013;8(2):e57418. doi: 10.1371/journal.pone.0057418. Epub 2013 Feb 27. PMID:23460853

42 Hao G, Kumar A, Dobin T, Oz OK, Hsieh JT, Sun X. A multivalent approach of imaging probe design to overcome an endogenous anion binding competition for noninvasive assessment of prostate specific membrane antigen. Mol Pharm. 2013 Aug 5;10(8):2975-85. doi: 10.1021/mp4000844. Epub 2013 Jun 28. PMID:23768233

43 Medin PM, Foster RD, van der Kogel AJ, Meyer J, Sayre JW, Huang H, Öz OK. Paralysis following stereotactic spinal irradiation in pigs suggests a tolerance constraint for single-session irradiation of the spinal nerve. Radiother Oncol. 2013 Oct;109(1):107-11. doi: 10.1016/j.radonc.2013.08.025. Epub 2013 Sep 20. PMID:24060168

44 Lazaga FJ, Oz OK, Adams-Huet B, Anderson J, Mathews D. Comparison of whole-body versus limited whole-body 18F-FDG PET/CT scan in malignant cutaneous melanoma. Clin Nucl Med. 2013 Nov;38(11):882-4. doi: 10.1097/RLU.0b013e3182a77cae. PMID:24096999

45 Lee C, Lo ST, Lim J, da Costa VC, Ramezani S, Öz OK, Pavan GM, Annunziata O, Sun X, Simanek EE. Design, synthesis and biological assessment of a triazine dendrimer with approximately 16 Paclitaxel groups and 8 PEG groups. Mol Pharm. 2013 Dec 2;10(12):4452-61. doi: 10.1021/mp400290u. Epub 2013 Nov 15. PMID:24134039

46 Wu K, Liu J, Tseng SF, Gore C, Ning Z, Sharifi N, Fazli L, Gleave M, Kapur P, Xiao G, Sun X, Oz OK, Min W, Alexandrakis G, Yang CR, Hsieh CL, Wu HC, He D, Xie D, Hsieh JT. The role of DAB2IP in androgen receptor activation during prostate cancer progression. Oncogene. 2014 Apr 10;33(15):1954-63. doi: 10.1038/onc.2013.143. Epub 2013 Apr 22. PMID:23604126

47 Kumar A, Lo ST, Öz OK, Sun X. Derivatization of (±) dihydrotetrabenazine for copper-64 labeling towards long-lived radiotracers for PET imaging of the vesicular monoamine transporter 2. Bioorg Med Chem Lett. 2014 Dec 15;24(24):5663-5. doi: 10.1016/j.bmcl.2014.10.070. Epub 2014 Oct 28. PMID:25467156

48 Hao G, Liu W, Hassan G, Öz OK, Kovacs Z, Sun X. A comparative study of trans- and cis-isomers of a bone-seeking agent, DO2A2P. Bioorg Med Chem Lett. 2015 Feb 1;25(3):571-4. doi: 10.1016/j.bmcl.2014.12.016. Epub 2014 Dec 13. PMID:25541387

49 Kumar A, Zhang S, Hao G, Hassan G, Ramezani S, Sagiyama K, Lo ST, Takahashi M, Sherry AD, Öz OK, Kovacs Z, Sun X. Molecular platform for design and synthesis of targeted dual-modality imaging probes. Bioconjug Chem. 2015 Mar 18;26(3):549-58. doi: 10.1021/acs.bioconjchem.5b00028. Epub 2015 Feb 20. PMID:25615011

50 Kumar A, Hao G, Liu L, Ramezani S, Hsieh JT, Öz OK, Sun X. Click-chemistry strategy for labeling antibodies with copper-64 via a cross-bridged tetraazamacrocyclic chelator scaffold. Bioconjug Chem. 2015 Apr 15;26(4):782-9. doi:10.1021/acs.bioconjchem.5b00102. Epub 2015 Mar 19. PMID:25760776

51 Lazaga F, Van Asten SA, Nichols A, Bhavan K, La Fontaine J, Oz OK, Lavery LA. Hybrid imaging with 99mTc-WBC SPECT/CT to monitor the effect of therapy in diabetic foot osteomyelitis. Int Wound J. 2015 Apr 8. doi: 10.1111/iwj.12433. [Epub ahead of print] PMID:25851182

52 Slavine NV, Guild J, McColl RW, Anderson JA, Oz OK, Lenkinski RE. An iterative deconvolution algorithm for image recovery in clinical CT: A phantom study. Phys Med. 2015 Jul 1. pii: S1120-1797(15)00149-0. doi: 10.1016/j.ejmp.2015.06.009. [Epub ahead of print] PMID:26143585

53 Pillai AK, Silvers W, Christensen P, Riegel M, Adams-Huet B, Lingvay I, Sun X, Öz OK. Comparative Evaluation of Two Venous Sampling Techniques for the Assessment of Pancreatic Insulin and Zinc Release upon Glucose Challenge. J Diabetes Res. 2015;2015:789359. doi: 10.1155/2015/789359. Epub 2015 Jul 27. PMID:26273676

54 Hajibeigi A, Dioum EM, Guo J, Öz OK. Identification of novel regulatory NFAT and TFII-I binding elements in the calbindin- D28k promoter in response to serum deprivation. Biochem Biophys Res Commun. 2015 Sep 25;465(3):414-20. doi: 10.1016/j.bbrc.2015.08.024. Epub 2015 Aug 7. PMID:26260319

55 Gerber DE, Hao G, Watkins L, Stafford JH, Anderson J, Holbein B, Öz OK, Mathews D, Thorpe PE, Hassan G, Kumar A, Brekken RA, Sun X. Tumor-specific targeting by Bavituximab, a phosphatidylserine-targeting monoclonal antibody with vascular targeting and immune modulating properties, in lung cancer xenografts. Am J Nucl Med Mol Imaging. 2015 Oct 12;5(5):493-503. eCollection 2015. PMID:26550540