Publications

Human CCDC51 and yeast Mdm33 are functionally conserved mitochondrial inner membrane proteins that demarcate a subset of organelle fission events.

Edington AR, Connor OM, Marlar-Pavey M, Friedman JR, 2024 Mar bioRxiv

Compositionally unique mitochondria in filopodia support cellular migration.

Marlar-Pavey M, Tapias-Gomez D, Mettlen M, Friedman JR, 2024 Jun bioRxiv

A dynamin superfamily-like pseudoenzyme coordinates with MICOS to promote cristae architecture.

Kumar A, Gok MO, Nguyen KN, Connor OM, Reese ML, Wideman JG, Muñoz-Gómez SA, Friedman JR, 2024 Apr Curr Biol

Completion of mitochondrial division requires the intermembrane space protein Mdi1/Atg44.

Connor OM, Matta SK, Friedman JR, 2023 Oct J Cell Biol 10 222

The outer mitochondrial membrane protein TMEM11 demarcates spatially restricted BNIP3/BNIP3L-mediated mitophagy.

Gok MO, Connor OM, Wang X, Menezes CJ, Llamas CB, Mishra P, Friedman JR, 2023 Apr J Cell Biol 4 222

ER-localized phosphatidylethanolamine synthase plays a conserved role in lipid droplet formation.

Gok MO, Speer NO, Henne WM, Friedman JR, 2021 Nov Mol Biol Cell mbcE21110558T

MICOS subcomplexes assemble independently on the mitochondrial inner membrane in proximity to ER contact sites.

Tirrell PS, Nguyen KN, Luby-Phelps K, Friedman JR, 2020 Nov J Cell Biol 11 219

Lipid Homeostasis Is Maintained by Dual Targeting of the Mitochondrial PE Biosynthesis Enzyme to the ER.

Friedman JR, Kannan M, Toulmay A, Jan CH, Weissman JS, Prinz WA, Nunnari J 2017 Dec Dev. Cell

MICOS coordinates with respiratory complexes and lipids to establish mitochondrial inner membrane architecture.

Friedman JR, Mourier A, Yamada J, McCaffery JM, Nunnari J 2015 Apr Elife 4

ER tubules mark sites of mitochondrial division.

Friedman JR, Lackner LL, West M, DiBenedetto JR, Nunnari J, Voeltz GK 2011 Oct Science 6054 334 358-62

Dual-localized PPTC7 limits mitophagy through proximal and dynamic interactions with BNIP3 and NIX.

Wei L, Gok MO, Svoboda JD, Kozul KL, Forny M, Friedman JR, Niemi NM, 2024 Sep Life Sci Alliance 9 7

Coordinating BNIP3/NIX-mediated mitophagy in space and time.

Niemi NM, Friedman JR, 2024 Oct Biochem Soc Trans

PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy.

Niemi NM, Serrano LR, Muehlbauer LK, Balnis CE, Wei L, Smith AJ, Kozul KL, Forny M, Connor OM, Rashan EH, Shishkova E, Schueler KL, Keller MP, Attie AD, Friedman JR, Pagan JK, Coon JJ, Pagliarini DJ, 2023 Oct Nat Commun 1 14 6431

Resolution doubling in light-sheet microscopy via oblique plane structured illumination.

Chen B, Chang BJ, Roudot P, Zhou F, Sapoznik E, Marlar-Pavey M, Hayes JB, Brown PT, Zeng CW, Lambert T, Friedman JR, Zhang CL, Burnette DT, Shepherd DP, Dean KM, Fiolka RP, 2022 Oct Nat Methods

Mitochondria from the Outside in: The Relationship Between Inter-Organelle Crosstalk and Mitochondrial Internal Organization.

Friedman JR, 2022 Contact (Thousand Oaks) 5

Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells.

Le Vasseur M, Friedman J, Jost M, Xu J, Yamada J, Kampmann M, Horlbeck MA, Salemi MR, Phinney BS, Weissman JS, Nunnari J, 2021 May Elife 10

MICOS and phospholipid transfer by Ups2-Mdm35 organize membrane lipid synthesis in mitochondria.

Aaltonen MJ, Friedman JR, Osman C, Salin B, di Rago JP, Nunnari J, Langer T, Tatsuta T 2016 Jun J. Cell Biol. 5 213 525-34

Mitochondrial hepato-encephalopathy due to deficiency of QIL1/MIC13 (C19orf70), a MICOS complex subunit.

Zeharia A, Friedman JR, Tobar A, Saada A, Konen O, Fellig Y, Shaag A, Nunnari J, Elpeleg O 2016 12 Eur. J. Hum. Genet. 12 24 1778-1782

Mitochondrial form and function.

Friedman JR, Nunnari J 2014 Jan Nature 7483 505 335-43

ER exit sites are physical and functional core autophagosome biogenesis components.

Graef M, Friedman JR, Graham C, Babu M, Nunnari J 2013 Sep Mol. Biol. Cell 18 24 2918-31

Endoplasmic reticulum-endosome contact increases as endosomes traffic and mature.

Friedman JR, Dibenedetto JR, West M, Rowland AA, Voeltz GK 2013 Apr Mol. Biol. Cell 7 24 1030-40

Identification of the DotL coupling protein subcomplex of the Legionella Dot/Icm type IV secretion system.

Vincent CD, Friedman JR, Jeong KC, Sutherland MC, Vogel JP 2012 Jul Mol. Microbiol. 2 85 378-91

The ER in 3D: a multifunctional dynamic membrane network.

Friedman JR, Voeltz GK 2011 Dec Trends Cell Biol. 12 21 709-17

ER sliding dynamics and ER-mitochondrial contacts occur on acetylated microtubules.

Friedman JR, Webster BM, Mastronarde DN, Verhey KJ, Voeltz GK 2010 Aug J. Cell Biol. 3 190 363-75

Identification of non-dot/icm suppressors of the Legionella pneumophila DeltadotL lethality phenotype.

Vincent CD, Buscher BA, Friedman JR, Williams LA, Bardill P, Vogel JP 2006 Dec J. Bacteriol. 23 188 8231-43

Identification of the core transmembrane complex of the Legionella Dot/Icm type IV secretion system.

Vincent CD, Friedman JR, Jeong KC, Buford EC, Miller JL, Vogel JP 2006 Dec Mol. Microbiol. 5 62 1278-91

Evidence that sequence homologous region in LRAT-like proteins possesses anti-proliferative activity and DNA binding properties: translational implications and mechanism of action.

Simmons DP, Peach ML, Friedman JR, Green MM, Nicklaus MC, De Luca LM 2006 Apr Carcinogenesis 4 27 693-707