The prevalence of obesity represents a major threat to human health globally. Obesity substantially increases the risk of various diseases such as type 2 diabetes, nonalcoholic fatty liver disease, hypertension, cardiovascular disease, and certain cancers. The preponderance of evidence supports a model in which susceptibility to obesity is largely determined by genetic factors, while the environment determines expression of phenotype.
We recently used a forward genetic screening platform, coupled with automated meiotic mapping, to identify genes that limit obesity. The screening and automated meiotic mapping ascribed obesity phenotypes to numerous genes—some previously associated with obesity and others not.
We are studying these new genes with various biochemical approaches and mouse models to find new mechanisms of obesity.
Worldwide prevalence of obesity by nation (2016 data). 
Mouse forward genetic screen of obesity.