Publications

2020

Nawas AF, Kanchwala M, Thomas-Jardin SE, Dahl H, Daescu K, Bautista M, Anunobi V, Wong A, Meade R, Mistry R, Ghatwai N, Bayerl F, Xing C, Delk NA. IL-1-conferred gene expression pattern in ERα⁺ BCa and AR⁺ PCa cells is intrinsic to ERα^- BCa and AR^- PCa cells and promotes cell survival. BMC Cancer. 2020 Jan 20;20(1):46. doi: 10.1186/s12885-020-6529-9. PubMed PMID: 31959131; PubMed Central PMCID: PMC6971947.

Niu Y, Bao L, Chen Y, Wang C, Luo M, Zhang B, Zhou M, Wang JE, Fang YV, Kumar A, Xing C, Wang Y, Luo W. HIF-2-induced long non-coding RNA RAB11B-AS1 promotes hypoxia-mediated angiogenesis and breast cancer metastasis. Cancer Res. 2020 Jan 3;. doi: 10.1158/0008-5472.CAN-19-1532. [Epub ahead of print] PubMed PMID: 31900259.

Xu C, Yang X, Zhou H, Li Y, Xing C, Zhou T, Zhong D, Lian C, Yan M, Chen T, Liao Z, Gao B, Su D, Wang T, Sharma S, Mohan C, Ahituv N, Malik S, Li QZ, Su P. A novel ZRS variant causes preaxial polydactyly type I by increased sonic hedgehog expression in the developing limb bud. Genet Med. 2020 Jan;22(1):189-198. doi: 10.1038/s41436-019-0626-7. Epub 2019 Aug 9. PubMed PMID: 31395945; PubMed Central PMCID: PMC6944640.

2019

Patni N, Hatab S, Xing C, Zhou Z, Quittner C, Garg A. A novel autosomal recessive lipodystrophy syndrome due to homozygous LMNA variant. J Med Genet. 2019 Dec 19;. doi: 10.1136/jmedgenet-2019-106395. [Epub ahead of print] PubMed PMID: 31857427.

Cuevas IC, Sahoo SS, Kumar A, Zhang H, Westcott J, Aguilar M, Cortez JD, Sullivan SA, Xing C, Hayes DN, Brekken RA, Bae-Jump VL, Castrillon DH. Fbxw7 is a driver of uterine carcinosarcoma by promoting epithelial-mesenchymal transition. Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25880-25890. doi: 10.1073/pnas.1911310116. Epub 2019 Nov 26. PubMed PMID: 31772025; PubMed Central PMCID: PMC6926017.

Zhang Z, Shao M, Hepler C, Zi Z, Zhao S, An YA, Zhu Y, Ghaben AL, Wang MY, Li N, Onodera T, Joffin N, Crewe C, Zhu Q, Vishvanath L, Kumar A, Xing C, Wang QA, Gautron L, Deng Y, Gordillo R, Kruglikov I, Kusminski CM, Gupta RK, Scherer PE. Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice. J Clin Invest. 2019 Dec 2;129(12):5327-5342. doi: 10.1172/JCI130239. PubMed PMID: 31503545; PubMed Central PMCID: PMC6877341.

Thomas-Jardin SE, Dahl H, Kanchwala MS, Ha F, Jacob J, Soundharrajan R, Bautista M, Nawas AF, Robichaux D, Mistry R, Anunobi V, Xing C, Delk NA. RELA is sufficient to mediate interleukin-1 repression of androgen receptor expression and activity in an LNCaP disease progression model. Prostate. 2019 Nov 15;. doi: 10.1002/pros.23925. [Epub ahead of print] PubMed PMID: 31730277.

Huang H, Zhang Y, Gallegos V, Sorrelle N, Zaid MM, Toombs J, Du W, Wright S, Hagopian M, Wang Z, Hosein AN, Sathe AA, Xing C, Koay EJ, Driscoll KE, Brekken RA. Targeting TGFβR2-mutant tumors exposes vulnerabilities to stromal TGFβ blockade in pancreatic cancer. EMBO Mol Med. 2019 Nov 7;11(11):e10515. doi: 10.15252/emmm.201910515. Epub 2019 Oct 14. PubMed PMID: 31609088; PubMed Central PMCID: PMC6835203.

Ross JL, Bloy L, Roberts TPL, Miller J, Xing C, Silverman LA, Zinn AR. Y chromosome gene copy number and lack of autism phenotype in a male with an isodicentric Y chromosome and absent NLGN4Y expression. Am J Med Genet B Neuropsychiatr Genet. 2019 Oct;180(7):471-482. doi: 10.1002/ajmg.b.32745. Epub 2019 Jun 3. PubMed PMID: 31161682; PubMed Central PMCID: PMC6730649.

Mirchia K, Sathe AA, Walker JM, Fudym Y, Galbraith K, Viapiano MS, Corona RJ, Snuderl M, Xing C, Hatanpaa KJ, Richardson TE. Total copy number variation as a prognostic factor in adult astrocytoma subtypes. Acta Neuropathol Commun. 2019 Jun 10;7(1):92. doi: 10.1186/s40478-019-0746-y. PubMed PMID: 31177992; PubMed Central PMCID: PMC6556960.

Fernandez-Perez A, Sathe AA, Bhakta M, Leggett K, Xing C, Munshi NV. Hand2 Selectively Reorganizes Chromatin Accessibility to Induce Pacemaker-like Transcriptional Reprogramming. Cell Rep. 2019 May 21;27(8):2354-2369.e7. doi: 10.1016/j.celrep.2019.04.077. PubMed PMID: 31116981; PubMed Central PMCID: PMC6657359.

Richardson TE, Patel S, Serrano J, Sathe AA, Daoud EV, Oliver D, Maher EA, Madrigales A, Mickey BE, Taxter T, Jour G, White CL, Raisanen JM, Xing C, Snuderl M, Hatanpaa KJ. Genome-Wide Analysis of Glioblastoma Patients with Unexpectedly Long Survival. J Neuropathol Exp Neurol. 2019 Apr 29;. doi: 10.1093/jnen/nlz025. [Epub ahead of print] PubMed PMID: 31034050.

Bhattacharyya S, Sathe AA, Bhakta M, Xing C, Munshi NV. PAN-INTACT enables direct isolation of lineage-specific nuclei from fibrous tissues. PLoS One. 2019;14(4):e0214677. doi: 10.1371/journal.pone.0214677. eCollection 2019. PubMed PMID: 30939177; PubMed Central PMCID: PMC6445515.

Liu Z, Mar KB, Hanners NW, Perelman SS, Kanchwala M, Xing C, Schoggins JW, Alto NM. A NIK-SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-κB. Nature. 2019 Apr;568(7751):249-253. doi: 10.1038/s41586-019-1041-6. Epub 2019 Mar 20. PubMed PMID: 30894749; PubMed Central PMCID: PMC6812682.

Zhang D, Zhou Z, Abu-Hijleh M, Batra K, Xing C, Garcia CK. Homozygous Rare PARN Missense Mutation in Familial Pulmonary Fibrosis. Am J Respir Crit Care Med. 2019 Mar 15;199(6):797-799. doi: 10.1164/rccm.201809-1632LE. PubMed PMID: 30525901; PubMed Central PMCID: PMC6423103.

Pelusi S, Baselli G, Pietrelli A, Dongiovanni P, Donati B, McCain MV, Meroni M, Fracanzani AL, Romagnoli R, Petta S, Grieco A, Miele L, Soardo G, Bugianesi E, Fargion S, Aghemo A, D'Ambrosio R, Xing C, Romeo S, De Francesco R, Reeves HL, Valenti LVC. Rare Pathogenic Variants Predispose to Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease. Sci Rep. 2019 Mar 6;9(1):3682. doi: 10.1038/s41598-019-39998-2. PubMed PMID: 30842500; PubMed Central PMCID: PMC6403344.

Babayev SN, Kanchwala M, Xing C, Akgul Y, Carr BR, Word RA. Thrombin Alters Human Endometrial Stromal Cell Differentiation During Decidualization. Reprod Sci. 2019 Feb;26(2):278-288. doi: 10.1177/1933719118768705. Epub 2018 Apr 15. PubMed PMID: 29658436; PubMed Central PMCID: PMC6728565.

Lu H, Sathe AA, Xing C, Lehrman MA. The Lec5 glycosylation mutant links homeobox genes with cholesterol and lipid-linked oligosaccharides. Glycobiology. 2019 Feb 1;29(2):106-109. doi: 10.1093/glycob/cwy103. PubMed PMID: 30388226; PubMed Central PMCID: PMC6330018

2018

Zhang, D., Zhou, Z., Abu-Hijleh, M., Batra, K., Xing, C., Garcia, C.K., 2018. Homozygous Rare PARN Missense Mutation in Familial Pulmonary Fibrosis. Am. J. Respir. Crit. Care Med. rccm.201809-1632LE.

Wambach, J.A., Wegner, D.J., Patni, N., Kircher, M., Willing, M.C., Baldridge, D., Xing, C., Agarwal, A.K., Vergano, S.A.S., Patel, C., Grange, D.K., Kenney, A., Najaf, T., Nickerson, D.A., Bamshad, M.J., Cole, F.S., Garg, A., 2018. Bi-allelic POLR3A Loss-of-Function Variants Cause Autosomal-Recessive Wiedemann-Rautenstrauch Syndrome. Am. J. Hum. Genet. 103, 968–975.

Lu, H., Sathe, A.A., Xing, C., Lehrman, M.A., 2018. Letter To The Glycoforum: The Lec5 Glycosylation Mutant Links Homeobox Genes with Cholesterol and Lipid-Linked Oligosaccharides. Glycobiology.

Zhou, Z., Ku, H.-C., Xing, G., Xing, C., 2018. Decomposing Pearson’s χ2 test: A linear regression and its departure from linearity. Ann. Hum. Genet. 82, 318–324.

Richardson, R.B., Ohlson, M.B., Eitson, J.L., Kumar, A., McDougal, M.B., Boys, I.N., Mar, K.B., De La Cruz-Rivera, P.C., Douglas, C., Konopka, G., Xing, C., Schoggins, J.W., 2018. A CRISPR screen identifies IFI6 as an ER-resident interferon effector that blocks flavivirus replication. Nat. Microbiol. 3, 1214–1223.

Saade, J.S., Xing, C., Gong, X., Zhou, Z., Mootha, V.V., 2018. Instability of TCF4 triplet repeat expansion with parent– child transmission in Fuchs’ endothelial corneal dystrophy. Investig. Ophthalmol. Vis. Sci. 59, 4065–4070.

Richardson, T.E., Sathe, A.A., Kanchwala, M., Jia, G., Habib, A.A., Xiao, G., Snuderl, M., Xing, C., Hatanpaa, K.J., 2018. Genetic and Epigenetic Features of Rapidly Progressing IDH-Mutant Astrocytomas. J. Neuropathol. Exp. Neurol. 77, 542–548.

Aboudehen, K., Farahani, S., Kanchwala, M., Chan, S.C., Avdulov, S., Mickelson, A., Lee, D., Gearhart, M.D., Patel, V., Xing, C., Igarashi, P., 2018. Long noncoding RNA Hoxb3os is dysregulated in autosomal dominant polycystic kidney disease and regulates mTOR signaling. J. Biol. Chem. 293, 9388–9398.

Thomas-Jardin, S.E., Kanchwala, M.S., Jacob, J., Merchant, S., Meade, R.K., Gahnim, N.M., Nawas, A.F., Xing, C., Delk, N.A., 2018. Identification of an IL-1-induced gene expression pattern in AR+PCa cells that mimics the molecular phenotype of AR−PCa cells. Prostate 78, 595–606.

Zheng, G., Kanchwala, M., Xing, C., Yu, H., 2018. MCM2–7-dependent cohesin loading during S phase promotes sister-chromatid cohesion. Elife 7.

Hu, J., Rong, Z., Gong, X., Zhou, Z., Sharma, V.K., Xing, C., Watts, J.K., Corey, D.R., Mootha, V.V., 2018. Oligonucleotides targeting TCF4 triplet repeat expansion inhibit RNA foci and mis-splicing in Fuchs’ dystrophy. Hum. Mol. Genet. 27, 1015–1026.

Li, X., Baek, G., Ramanand, S.G., Sharp, A., Gao, Y., Yuan, W., Welti, J., Rodrigues, D.N., Dolling, D., Figueiredo, I., Sumanasuriya, S., Crespo, M., Aslam, A., Li, R., Yin, Y., Mukherjee, B., Kanchwala, M., Hughes, A.M., Halsey, W.S., Chiang, C.-M., Xing, C., Raj, G. V., Burma, S., de Bono, J., Mani, R.S., 2018. BRD4 Promotes DNA Repair and Mediates the Formation of TMPRSS2-ERG Gene Rearrangements in Prostate Cancer. Cell Rep. 22, 796–808.

Babayev, S.N., Kanchwala, M., Xing, C., Akgul, Y., Carr, B.R., Word, R.A., 2018. Thrombin Alters Human Endometrial Stromal Cell Differentiation During Decidualization. Reprod. Sci. 193371911876870.

De La Cruz-Rivera, P.C., Kanchwala, M., Liang, H., Kumar, A., Wang, L.-F., Xing, C., Schoggins, J.W., 2018. The IFN Response in Bats Displays Distinctive IFN-Stimulated Gene Expression Kinetics with Atypical RNASEL Induction. J. Immunol. 200, 209–217.

Chen, Y., Zhang, B., Bao, L., Jin, L., Yang, M., Peng, Y., Kumar, A., Wang, J.E., Wang, C., Zou, X., Xing, C., Wang, Y., Luo, W., 2018. ZMYND8 acetylation mediates HIF-dependent breast cancer progression and metastasis. J. Clin. Invest. 128, 1937–1955.