Publications

Peer-Reviewed Publications (selected)

For the most up to date listing of publications, please see:

Schoggins Lab Publication List

Kober DL, Caballero Van Dyke MC, Eitson JL, Boys IN, McDougal MB, Rosenbaum DM, Schoggins JW.
Development of a mutant aerosolized ACE2 that neutralizes SARS-CoV-2 in vivo.
mBio. 2024 Jun 12;15(6):e0076824. 

Carreno-Florez GP, Kocak BR, Hendricks MR, Melvin JA, Mar KB, Kosanovich J, Cumberland RL, Delgoffe GM, Shiva S, Empey KM, Schoggins JW, Bomberger JM. 
Interferon signaling drives epithelial metabolic reprogramming to promote secondary bacterial infection. 
PLoS Pathog. 2023 Nov 8;19(11):e1011719. 

McDougal MB, De Maria AM, Ohlson MB, Kumar A, Xing C, Schoggins JW.
Interferon inhibits a model RNA virus via a limited set of inducible effector genes.
EMBO Rep. 2023 Sep 6;24(9):e56901.

Mar KB, Wells AI, Caballero Van Dyke MC, Lopez AH, Eitson JL, Fan W, Hanners NW, Evers BM, Shelton JM, Schoggins JW.
LY6E is a pan-coronavirus restriction factor in the respiratory tract.
Nat Microbiol. 2023 Aug;8(8):1587-1599.

Ahmed MS, Farag AB, Boys IN, Wang P, Menendez-Montes I, Nguyen NUN, Eitson JL, Ohlson MB, Fan W, McDougal MB, Mar K, Thet S, Ortiz F, Kim SY, Solmonson A, Williams NS, Lemoff A, DeBerardinis RJ, Schoggins JW, Sadek HA.
FDA approved drugs with antiviral activity against SARS-CoV-2: From structure-based repurposing to host-specific mechanisms.
Biomed Pharmacother. 2023 Jun;162:114614. 

Ohlson MB, Eitson JL, Wells AI, Kumar A, Jang S, Ni C, Xing C, Buszczak M, Schoggins JW.
Genome-Scale CRISPR Screening Reveals Host Factors Required for Ribosome Formation and Viral Replication.
mBio. 2023 Apr 25;14(2):e0012723. 

Rehfeld F, Eitson JL, Ohlson MB, Chang TC, Schoggins JW, Mendell JT.
CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication.
Cell Rep. 2023 Feb 28;42(2):112076. 

Heisler DB, Johnson KA, Ma DH, Ohlson MB, Zhang L, Tran M, Corley CD, Abrams ME, McDonald JG, Schoggins JW, Alto NM, Radhakrishnan A.
A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection.
Elife. 2023 Jan 25;12:e83534. 

Galal MW, Ahmed M, Shao Y, Xing C, Ali W, Baly AE, Elfiky A, Amer K, Schoggins J, Sadek HA, Gobara ZN.
The Use of Mebendazole in COVID-19 Patients: An Observational Retrospective Single Center Study.
Adv Virol. 2022 Dec 10;2022:3014686. 

Göczi L, Csumita M, Horváth A, Nagy G, Póliska S, Pigni M, Thelemann C, Dániel B, Mianesaz H, Varga T, Sen K, Raghav SK, Schoggins JW, Nagy L, Acha- Orbea H, Meissner F, Reith W, Széles L.
A Multi-Omics Approach Reveals Features That Permit Robust and Widespread Regulation of IFN-Inducible Antiviral Effectors.
J Immunol. 2022 Nov 15;209(10):1930-1941. 

Jain MK, De Lemos JA, McGuire DK, Ayers C, Eitson JL, Sanchez CL, Kamel D, Meisner JA, Thomas EV, Hegde AA, Mocherla S, Strebe JK, Li X, Williams NS, Xing C, Ahmed MS, Wang P, Sadek HA, Schoggins JW.
Atovaquone for treatment of COVID-19: A prospective randomized, double-blind, placebo-controlled clinical trial. 
Front Pharmacol. 2022 Sep 30;13:1020123. 

Fan W, McDougal MB, Schoggins JW.
Enterovirus 3C Protease Cleaves TRIM7 To Dampen Its Antiviral Activity.
J Virol. 2022 Oct 12;96(19):e0133222. 

Park GJ, Osinski A, Hernandez G, Eitson JL, Majumdar A, Tonelli M, Henzler-Wildman K, Pawłowski K, Chen Z, Li Y, Schoggins JW, Tagliabracci VS.
The mechanism of RNA capping by SARS-CoV-2.
Nature. 2022 Sep;609(7928):793-800. 

Kumata R, Iwanami S, Mar KB, Kakizoe Y, Misawa N, Nakaoka S, Koyanagi Y, Perelson AS, Schoggins JW, Iwami S, Sato K. 
Antithetic effect of interferon-α on cell-free and cell-to-cell HIV-1 infection.
PLoS Comput Biol. 2022 Apr 25;18(4):e1010053.

Hanners NW, Mar KB, Boys IN, Eitson JL, De La Cruz-Rivera PC, Richardson RB, Fan W, Wight-Carter M, Schoggins JW.
Shiftless inhibits flavivirus replication in vitro and is neuroprotective in a mouse model of Zika virus pathogenesis.
Proc Natl Acad Sci U S A. 2021 Dec 7;118(49):e2111266118. 

Rinkenberger N, Abrams ME, Matta SK, Schoggins JW, Alto NM, Sibley LD.
Overexpression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection.
Elife. 2021 Dec 6;10:e73137.

Khan S, Shafiei MS, Longoria C, Schoggins JW, Savani RC, Zaki H.
SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway.
Elife. 2021 Dec 6;10:e68563.

Li E, Guo J, Oh SJ, Luo Y, Oliveros HC, Du W, Arano R, Kim Y, Chen YT, Eitson J, Lin DT, Li Y, Roberts T, Schoggins JW, Xu W.
Anterograde transneuronal tracing and genetic control with engineered yellow fever vaccine YFV-17D.
Nat Methods. 2021 Dec;18(12):1542-1551.

Fan W, Mar KB, Sari L, Gaszek IK, Cheng Q, Evers BM, Shelton JM, Wight-Carter M, Siegwart DJ, Lin MM, Schoggins JW.
TRIM7 inhibits enterovirus replication and promotes emergence of a viral variant with increased pathogenicity.
Cell. 2021 Jun 24;184(13):3410-3425.e17.

Muthukumar A, Narasimhan M, Li QZ, Mahimainathan L, Hitto I, Fuda F, Batra K, Jiang X, Zhu C, Schoggins J, Cutrell JB, Croft CL, Khera A, Drazner MH, Grodin JL, Greenberg BM, Mammen PPA, Morrison SJ, de Lemos JA.
In Depth Evaluation of a Case of Presumed Myocarditis Following the Second Dose of COVID-19 mRNA Vaccine.
Circulation. 2021 Jun 16. doi: 10.1161/CIRCULATIONAHA.121.056038. Epub ahead of print.

Boys IN, Mar KB, Schoggins JW.
Functional-genomic analysis reveals intraspecies diversification of antiviral receptor transporter proteins in Xenopus laevis.
PLoS Genet. 2021 May 20;17(5):e1009578.

Filkins L, SoRelle JA, Schoggins J, Park JY.
Laboratory Action Plan for Emerging SARS-CoV-2 Variants.
Clin Chem. 2021 Apr 29;67(5):720-723.

van Oers NSC, Hanners NW, Sue PK, Aquino V, Li QZ, Schoggins JW, Wysocki CA. 
SARS-CoV-2 infection associated with hepatitis in an infant with X-linked severe combined immunodeficiency.
Clin Immunol. 2021 Mar;224:108662.

Dong X, Yang Y, Zou Z, Zhao Y, Ci B, Zhong L, Bhave M, Wang L, Kuo YC, Zang X, Zhong R, Aguilera ER, Richardson RB, Simonetti B, Schoggins JW, Pfeiffer JK, Yu L, Zhang X, Xie Y, Schmid SL, Xiao G, Gleeson PA, Ktistakis NT, Cullen PJ, Xavier RJ, Levine B.
Sorting nexin 5 mediates virus-induced autophagy and immunity.
Nature. 2021 Jan;589(7842):456-461.

Boys IN, Xu E, Mar KB, De La Cruz-Rivera PC, Eitson JL, Moon B, Schoggins JW.
RTP4 Is a Potent IFN-Inducible Anti-flavivirus Effector Engaged in a Host-Virus Arms Race in Bats and Other Mammals.
Cell Host Microbe. 2020 Nov 11;28(5):712-723.e9.

Pfaender S, Mar KB, Michailidis E, Kratzel A, Boys IN, V'kovski P, Fan W, Kelly JN, Hirt D, Ebert N, Stalder H, Kleine-Weber H, Hoffmann M, Heinrich Hoffmann H, Saeed M, Dijkman R, Steinmann E, Wight-Carter M, McDougal MB, Hanners NW, Pöhlmann S, Gallagher T, Todt D, Zimmer G, Rice CM, Schoggins JW, Thiel V.
LY6E impairs coronavirus fusion and confers immune control of viral disease.
Nat Microbiol. 2020 Nov;5(11):1330-1339.

Kuroda M, Halfmann PJ, Hill-Batorski L, Ozawa M, Lopes TJS, Neumann G, Schoggins JW, Rice CM, Kawaoka Y.
Identification of interferon-stimulated genes that attenuate Ebola virus infection.
Nature Communications. 2020 Jun 11;11(1):2953.

Ramanathan HN, Zhang S, Douam F, Mar KB, Chang J, Yang PL, Schoggins JW, Ploss A, Lindenbach BD.
A Sensitive Yellow Fever Virus Entry Reporter Identifies Valosin-Containing Protein (VCP/p97) as an Essential Host Factor for Flavivirus Uncoating.
mBio. 2020 Apr 14;11(2):e00467-20.

Abrams ME, Johnson KA, Perelman SS, Zhang LS, Endapally S, Mar KB, Thompson BM, McDonald JG, Schoggins JW, Radhakrishnan A, Alto NM.
Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol.
Nature Microbiology. 2020 Jul;5(7):929-942.

Rinkenberger N, Schoggins JW.
Comparative analysis of viral entry for Asian and African lineages of Zika virus.
Virology. 2019 Jul;533:59-67.

Liu Z, Mar KB, Hanners NW, Perelman SS, Kanchwala M, Xing C, Schoggins JW, Alto NM.
A NIK-SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-κB.
Nature. 2019 Apr;568(7751):249-253.

Hubel P, Urban C, Bergant V, Schneider WM, Knauer B, Stukalov A, Scaturro P, Mann A, Brunotte L, Hoffmann HH, Schoggins JW, Schwemmle M, Mann M, Rice CM, Pichlmair A.
A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.
Nature Immunology. 2019 Apr;20(4):493-502. 

Richardson RB, Ohlson MB, Eitson JL, Kumar A, McDougal MB, Boys IN, Mar KB, De La Cruz-Rivera PC, Douglas C, Konopka G, Xing C, Schoggins JW.
A CRISPR screen identifies IFI6 as an ER-resident interferon effector that blocks flavivirus replication.
Nature Microbiology. 2018 Nov;3(11):1214-1223.

Mar KB, Rinkenberger NR, Boys IN, Eitson JL, McDougal MB, Richardson RB, Schoggins JW.
LY6E mediates an evolutionarily conserved enhancement of virus infection by targeting a late entry step.
Nature Communications. 2018 Sep 6;9(1):3603.

Rinkenberger N, Schoggins JW.
Mucolipin-2 Cation Channel Increases Trafficking Efficiency of Endocytosed Viruses.
MBio. 2018 Jan 30;9(1)

De La Cruz-Rivera PC, Kanchwala M, Liang H, Kumar A, Wang LF, Xing C, Schoggins JW.
The IFN Response in Bats Displays Distinctive IFN-Stimulated Gene
Expression Kinetics with Atypical RNASEL Induction.
J Immunol. 2018 Jan 1;200(1):209-217. 

Rosenberg BR, Freije CA, Imanaka N, Chen ST, Eitson JL, Caron R, Uhl SA, Zeremski M, Talal A, Jacobson IM, Rice CM, Schoggins JW.
Genetic Variation at IFNL4 Influences Extrahepatic Interferon-Stimulated Gene Expression in Chronic HCV Patients.
J Infect Dis. 2018 Jan 30;217(4):650-655.

Lipovsky A, Erden A, Kanaya E, Zhang W, Crite M, Bradfield C, MacMicking J, DiMaio D, Schoggins JW, Iwasaki A.
The cellular endosomal protein stannin inhibits intracellular trafficking of human papillomavirus during virus entry.
J  Gen Virol. 2017 Nov;98(11):2821-2836.

Perelman SS, Abrams ME, Eitson JL, Chen D, Jimenez A, Mettlen M, Schoggins JW, Alto NM.
Cell-Based Screen Identifies Human Interferon-Stimulated Regulators of Listeria monocytogenes Infection.
PLoS Pathog. 2016 Dec 21;12(12):e1006102.

Kane M, Zang TM, Rihn SJ, Zhang F, Kueck T, Alim M, Schoggins J, Rice CM, Wilson SJ, Bieniasz PD.
Identification of Interferon-Stimulated Genes with Antiretroviral Activity.
Cell Host Microbe. 2016 Sep 14;20(3):392-405. 

Hanners NW, Eitson JL, Usui N, Richardson RB, Wexler EM, Konopka G, Schoggins JW.
Western Zika Virus in Human Fetal Neural Progenitors Persists Long Term with  Partial Cytopathic and Limited Immunogenic Effects.
Cell Rep. 2016 Jun 14;15(11):2315-22.

Feenstra B, Pasternak B, Geller F, Carstensen L, Wang T, Huang F, Eitson JL, Hollegaard MV, Svanström H, Vestergaard M, Hougaard DM, Schoggins JW, Jan LY, Melbye M, Hviid A.
Common variants associated with general and MMR vaccine-related febrile seizures.
Nature Genetics. 2014 Dec;46(12):1274-82.

Schoggins JW, MacDuff DA, Imanaka N, Gainey MD, Shrestha B, Eitson JL, Mar KB, Richardson RB, Ratushny AV, Litvak V, Dabelic R, Manicassamy B, Aitchison JD, Aderem A, Elliott RM, García-Sastre A, Racaniello V, Snijder EJ, Yokoyama WM, Diamond MS, Virgin HW, Rice CM.
Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity.
Nature. 2014 Jan 30;505(7485):691-5.

Kane M, Yadav SS, Bitzegeio J, Kutluay SB, Zang T, Wilson SJ, Schoggins JW, Rice CM, Yamashita M, Hatziioannou T, Bieniasz PD.
MX2 is an interferon-induced inhibitor of HIV-1 infection.
Nature. 2013 Oct 24;502(7472):563-6.

Reviews, Chapters, Commentaries

McDougal MB, Boys IN, De La Cruz-Rivera P, Schoggins JW. Evolution of the interferon response: lessons from ISGs of diverse mammals. Curr Opin Virol. 2022 Apr;53:101202.

Schoggins JW. Interferon-Stimulated Genes: What Do They All Do? Annu Rev Virol. 2019 Sep 29;6(1):567-584.

Lazear HM, Schoggins JW, Diamond MS. Shared and Distinct Functions of Type I and Type III Interferons. Immunity. 2019 Apr 16;50(4):907-923.

Recent advances in antiviral interferon-stimulated gene biology. Schoggins JW.  F1000Res. 2018 Mar 12;7:309.

NLRX1 Helps HIV Avoid a STING Operation. Mar KB, Schoggins JW. Cell Host Microbe. 2016 Apr 13;19(4):430-1.

A phospholipase linkAGE to SARS susceptibility. Schoggins JW. J Exp Med. 2015 Oct 19;212(11):1755.

IMMUNOLOGY. Viruses carry antiviral cargo. Schoggins JW. Science. 2015 Sep 11;349(6253):1166-7.

A Sense of Self: RIG-I's Tolerance to Host RNA. Schoggins JW. Immunity. 2015 Jul 21;43(1):1-2.

Interferon-stimulated genes: roles in viral pathogenesis. Schoggins JW. Curr Opin Virol. 2014 Jun;6:40-6.

Lipids in innate antiviral defense. Schoggins JW, Randall G. Cell Host Microbe. 2013 Oct 16;14(4):379-85.

Regulating interferon antiviral activity: a role for epidermal growth factor receptor. Schoggins JW. Hepatology. 2013 Oct;58(4):1200-2.

Host restriction factor screening: let the virus do the work. Diamond MS, Schoggins JW. Cell Host Microbe. 2013 Sep 11;14(3):229-31.

Innate immune responses to hepatitis C virus. Schoggins JW, Rice CM. Curr Top Microbiol Immunol. 2013;369:219-42.

Interferon-stimulated genes and their antiviral effector functions. Schoggins JW and Rice CM. Current Opinion in Virology. 1(6):519-525. 2011. 

Adenovirus capsid chimeras: fiber terminal exon insertions/gene replacements in the major late transcription unit. Gall J, Schoggins J, Falck-Pedersen E. Methods Mol Med. 130:107-23. 2007.