Petroll Lab

Cell Mechanics and Corneal Wound Healing

Located in the Department of Ophthalmology, the Petroll Lab applies engineering approaches and design principles to the investigation of fundamental clinical and biological problems in ophthalmology, while providing training to graduate students, medical students, and postdocs.

Research

The main focus of the Petroll Lab’s research is cell mechanics and tissue engineering, whereby multidimensional time-lapse imaging is used to investigate how the mechanical behavior of corneal fibroblasts is regulated by both biochemical and biophysical stimuli. Our lab also has a longstanding interest in the development and application of in vivo confocal microscopy and in situ multiphoton imaging, which allow quantitative 3-D assessment of cell differentiation and extracellular matrix organization during corneal wound healing in response to clinical procedures such as refractive surgery or UV cross-linking.

applied research We develop and apply in vivo confocal microscopy and in situ multiphoton imaging techniques to assess the cellular responses to corneal injury, disease and refractive surgical procedures.

We use multidimensional time-lapse imaging to investigate how the behavior of corneal fibroblasts is regulated by biochemical and biophysical stimuli encountered during wound healing.

Male scientist showing two female grad students an image on a computer screen.
    Cell Mechanics

    Overview

    The organization of extracellular matrices by cells through the exertion of mechanical forces drives fundamental processes such as developmental morphogenesis, wound healing, and the organization of bioengineered tissues. Historically, our ability to investigate cell mechanical behavior has been limited by the technical challenges associated with measuring the sub-cellular origins of cellular force generation and local matrix patterning in a 3-D environment. Thus, our understanding of these fundamental processes is limited, especially in ocular tissues. Over the last several years, our research team has addressed these challenges through the development of new experimental models, use of emerging imaging technologies, and the application of quantitative analysis techniques. 

    Experimental Models

    Our in vitro approaches include: 1) models for assessing how specific growth factors expressed following injury or surgery alter the mechanical differentiation of quiescent corneal keratocytes within 3-D collagen matrices, 2) novel approaches for assessing the response of fibroblasts to dynamic changes in ECM mechanical properties (as might be observed during development or wound healing), 3) 3-D constructs for assessing the mechanical interplay between fibroblast migration, sub-cellular force generation, and ECM patterning, and 4) engineered substrates that allow investigation of the impact of ECM protein composition, topography, and elasticity on cell differentiation and mechanical behavior.

    Together, these experimental models are providing unique insights into the underlying biochemical and biomechanical signaling mechanisms controlling corneal fibroblast migration, contraction, and matrix reorganization. This is fundamental information which can not be obtained using standard 2-D culture models, and may eventually lead to improved strategies for modulating cell mechanical activity during wound healing, and for designing artificial matrices and directing cell behavior during corneal tissue engineering. 

    Corneal Wound Healing

    The cornea is an optically clear tissue that forms the front surface of the eye, and accounts for nearly two-thirds of its refractive power. The corneal stroma, which makes up 90% of corneal thickness, is a highly organized structure consisting of collagen lamellae with specific packing and spacing that is critical to maintenance of corneal transparency. Corneal stromal cells (keratocytes) reside between the collagen lamellae, and are responsible for secreting extracellular matrix (ECM) components required to maintain normal corneal structure and function (i.e. transparency). Because it is exposed, the cornea is susceptible to infection, physical and chemical injuries; it is also the target of many vision correction procedures.

    Stromal keratocytes play a central role in mediating the corneal response to lacerating injury, chemical injuries or surgical procedures. During wound healing, quiescent corneal keratocytes surrounding the area of injury generally become activated, and transform into a fibroblastic repair phenotype. In certain wound types, fibroblasts further differentiate into myofibroblasts, which generate stronger forces and synthesize a disorganized fibrotic ECM. Cellular force generation and fibrosis can alter corneal shape and/or reduce corneal transparency, thereby reducing visual acuity.

    In addition to fibrosis which develops on top of the wound bed, most vision correction procedures induce keratocyte death beneath the laser-treated area.  Stromal cell death can also be induced by toxic injury, as well as UV cross-linking (CXL) of the cornea in keratoconus patients. Ideally, repopulation following these insults should occur via intra-stromal migration of keratocytes from the surrounding stromal tissue, without generation of strong contractile forces that could disrupt the collagen architecture and lead to vision loss.

    Our lab develops and applies high resolution imaging and image processing approaches to better understand and potentially modulate these healing responses. Specifically, we use in vivo confocal microscopy to assess stromal keratocyte differentation, patterning and activation in response corneal injury, surgery, or disease. We also use 3-D confocal and multiphoton imaging of corneal tissue ex vivo to assess the expression and localization of specific proteins associated with wound healing (using fluorescent labeling) as well as changes in extracellular matrix organization (using second harmonic generation imaging).1,2

    References

    1. Petroll WM, Kivanany PB, Hagenasr D, Graham EK. Corneal Fibroblast Migration Patterns During Intrastromal Wound Healing Correlate With ECM Structure and Alignment. Invest Ophthalmol Vis Sci. 2015 Nov;56(12):7352-61.

    2. Kivanany PB, Grose KC, Tippani M, Su S, Petroll WM. Assessment of Corneal Stromal Remodeling and Regeneration after Photorefractive Keratectomy. Sci Rep. 2018 Aug 22;8(1):12580. 

    Video: About the Petroll Lab

    Meet the Principal Investigator

    Dr. Petroll in lab coat holding up and examining lab samples.

    W. Matthew Petroll, Ph.D.

    Dr. Petroll is a Professor of Ophthalmology and Biomedical Engineering at UT Southwestern Medical Center. He received his B.S. degree in Biomedical Engineering from Duke University in 1984, and his Ph.D. in Biomedical Engineering from the University of Virginia in 1989. After two years at Georgetown University in the lab of Drs. James Jester and Dwight Cavanagh, he joined the faculty at UT Southwestern in 1991. He was promoted to professor in 2005, and became Chair of the Graduate Program in Biomedical Engineering in 2012.

    Dr. Petroll’s laboratory applies engineering approaches and design principles to the investigation of fundamental clinical and biological problems in ophthalmology, while providing training to graduate students, medical students, and post-docs. The main focus of Dr. Petroll’s research is cell mechanics and tissue engineering, in which multidimensional time-lapse imaging is used to investigate how the mechanical behavior of corneal fibroblasts is regulated by both biochemical and biophysical stimuli. He also has a longstanding interest in the development and application of in vivo confocal microscopy, which allows quantitative 3-D imaging of the cornea and has been used in numerous research and clinical studies on corneal wound healing, toxicity, development and infection.

    View Faculty Profile

    Publications

    Opioid Usage Following Oculoplastic Procedures

    Mei F, Garfinkel V, Petroll M, Mancini R 2024 Jul 44 699-705

    The Role of Vimentin in Human Corneal Fibroblast Spreading and Myofibroblast Transformation

    Miron-Mendoza M, Poole K, DiCesare S, Nakahara E, Bhatt MP, Hulleman JD, Petroll WM 2024 Jul 13

    Correction to: Experimental Models for Investigating Intra-Stromal Migration of Corneal Keratocytes, Fibroblasts and Myofibroblasts (Journal of Functional Biomaterials, (2012), 3, 1, (183-198), 10.3390/jfb3010183)

    Petroll WM, Lakshman N, Ma L 2024 Jul 15

    Fabrication of Micropatterns of Aligned Collagen Fibrils

    Subramanian D, Tjahjono NS, Hernandez PA, Varner VD, Petroll WM, Schmidtke DW 2024 Feb 40 2551-2561

    The impact of UV cross-linking on corneal stromal cell migration, differentiation and patterning

    Petroll WM, Miron-Mendoza M, Sunkara Y, Ikebe HR, Sripathi NR, Hassaniardekani H 2023 Aug 233

    Sutureless Conjunctiva-Sparing Posterior Ptosis Repair Surgery: A Novel Technique

    Mancini R, Forouzan P, Keenum ZG, Tenzel PA, Petroll WM 2023 Jul 251 77-89

    Effects of Topography and PDGF on the Response of Corneal Keratocytes to Fibronectin-Coated Surfaces

    Lam KH, Shihabeddin TZ, Awkal JA, Najjar AM, Miron-Mendoza M, Maruri DP, Varner VD, Petroll WM, Schmidtke DW 2023 Apr 14

    Loss of Corneal Nerves and Corneal Haze in Patients with Fuchs’ Endothelial Corneal Dystrophy with the Transcription Factor 4 Gene Trinucleotide Repeat Expansion

    Gillings M, Mastro A, Zhang X, Kiser K, Gu J, Xing C, Robertson DM, Petroll WM, Mootha VV 2023 Mar 3

    Temporal and Spatial Assessment of the Corneal Response to UV Cross-Linking Using 3-Dimensional In Vivo Confocal Microscopy

    Parsa S, Rodriguez A, Robertson DM, Bowman RW, Petroll WM 2022 Jul 48 308-312

    Quercetin Decreases Corneal Haze In Vivo and Influences Gene Expression of TGF-Beta Mediators In Vitro

    McKay TB, Kivanany PB, Nicholas SE, Nag OK, Elliott MH, Petroll WM, Karamichos D 2022 Jul 12

    ECM stiffness modulates the proliferation but not the motility of primary corneal keratocytes in response to PDGF-BB

    Iyer KS, Maruri DP, Peak KE, Schmidtke DW, Petroll WM, Varner VD 2022 Jul 220

    Signaling Downstream of Focal Adhesions Regulates Stiffness-Dependent Differences in the TGF-β1-Mediated Myofibroblast Differentiation of Corneal Keratocytes

    Maruri DP, Iyer KS, Schmidtke DW, Petroll WM, Varner VD 2022 May 10

    Risk assessment in deferred and recovered donors

    Heck E, Corder V, Urban J, Petroll M, Timmons W, Cavanaugh D 2021 Dec 22 623-629

    Infectious keratitis after corneal crosslinking: systematic review

    Murchison CE, Petroll WM, Robertson DM 2021 Aug 47 1075-1080

    Evaluation of the repeatability of the lacrydiag ocular surface analyzer for assessment of the meibomian glands and tear film

    Ward CD, Murchison CE, Petroll WM, Robertson DM 2021 Aug 10

    ECM Stiffness Controls the Activation and Contractility of Corneal Keratocytes in Response to TGF-β1

    Maruri DP, Miron-Mendoza M, Kivanany PB, Hack JM, Schmidtke DW, Petroll WM, Varner VD 2020 Nov 119 1865-1877

    Fibulin-3 knockout mice demonstrate corneal dysfunction but maintain normal retinal integrity

    Daniel S, Renwick M, Chau VQ, Datta S, Maddineni P, Zode G, Wade EM, Robertson SP, Petroll WM, Hulleman JD 2020 Nov 98 1639-1656

    Keratocyte mechanobiology

    Petroll WM, Varner VD, Schmidtke DW 2020 Nov 200

    Lower corneal haze and aberrations in Descemet membrane endothelial keratoplasty versus Descemet stripping automated endothelial keratoplasty in fellow eyes for Fuchs endothelial corneal dystrophy

    Waldrop WH, Gillings MJ, Robertson DM, Petroll WM, Mootha VV 2020 Oct 39 1227-1234

    Positive toxicology and reactive serology in tissue donors: a retrospective study over a 3-year period

    Heck E, Gruslin K, Corder V, Petroll WM, Urban J 2020 Sep 21 427-431

    Outcomes of resident-performed laser-assisted vs traditional phacoemulsification

    Hansen B, Blomquist PH, Ririe P, Pouly S, Nguyen C, Petroll WM, McCulley JP 2020 Sep 46 1273-1277

    Coupling of fibrin reorganization and fibronectin patterning by corneal fibroblasts in response to pdgf bb and tgfβ1

    Miron-Mendoza M, Vazquez D, García-Rámila N, Ikebe HR, Petroll WM 2020 Aug 7 1-18

    A high-throughput microfluidic method for fabricating aligned collagen fibrils to study Keratocyte behavior

    Lam KH, Kivanany PB, Grose K, Yonet-Tanyeri N, Alsmadi N, Varner VD, Petroll WM, Schmidtke DW 2019 Dec 21

    Assessment of Corneal Stromal Remodeling and Regeneration after Photorefractive Keratectomy

    Kivanany PB, Grose KC, Tippani M, Su S, Petroll WM 2018 Dec 8

    An in vitro model for assessing corneal keratocyte spreading and migration on aligned fibrillar collagen

    Kivanany PB, Grose KC, Yonet-Tanyeri N, Manohar S, Sunkara Y, Lam KH, Schmidtke DW, Varner VD, Petroll WM 2018 Sep 9

    Fibroblast-fibronectin patterning and network formation in 3D fibrin matrices

    Miron-Mendoza M, Graham E, Manohar S, Petroll WM 2017 Dec 64 69-80

    Second harmonic generation imaging of corneal stroma after infection by Pseudomonas aeruginosa

    Robertson DM, Rogers NA, Petroll WM, Zhu M 2017 Apr 7

    Temporal and spatial analysis of stromal cell and extracellular matrix patterning following lamellar keratectomy

    Kivanany PB, Grose KC, Petroll WM 2016 Dec 153 56-64

    Immunomodulatory therapy with anti-interleukin-1 after photorefractive keratectomy in the New Zealand white rabbit

    Taylor KR, Panday VA, Caldwell MC, Petroll WM, Apsey DA, Reilly CD 2016 Jun 42 913-919

    Corneal fibroblast migration patterns during intrastromal wound healing correlate with ECM structure and alignment

    Petroll WM, Kivanany PB, Hagenasr D, Graham EK 2015 Nov 56 7352-7361

    Impact of donor age on corneal endothelium-descemet membrane layer scroll formation

    Bennett A, Mahmoud S, Drury D, Cavanagh HD, McCulley JP, Petroll WM, Mootha V 2015 Jul 41 236-239

    In Vivo Confocal Microscopy of the Cornea: New Developments in Image Acquisition, Reconstruction, and Analysis Using the HRT-Rostock Corneal Module

    Petroll WM, Robertson DM 2015 Jul 13 187-203

    Severing corneal nerves in one eye induces sympathetic loss of immune privilege and promotes rejection of future corneal allografts placed in either eye

    Paunicka KJ, Mellon J, Robertson D, Petroll M, Brown JR, Niederkorn JY 2015 Jun 15 1490-1501

    Effect of HDAC inhibitors on corneal keratocyte mechanical phenotypes in 3-D collagen matrices

    Koppaka V, Lakshman N, Matthew Petroll W 2015 Apr 21 502-514

    Introduction to special issue on ocular ECM

    Al-Ubaidi M, Petroll WM 2015 Apr 133 1-2

    Mechanical interactions and crosstalk between corneal keratocytes and the extracellular matrix

    Petroll WM, Miron-Mendoza M 2015 Apr 133 49-57

    The Role of Thrombin and Cell Contractility in Regulating Clustering and Collective Migration of Corneal Fibroblasts in Different ECM Environments

    Miron-Mendoza M, Graham E, Kivanany P, Quiring J, Petroll WM 2015 Mar 56 2079-2090

    TCF4 Triplet Repeat Expansion and Nuclear RNA Foci in Fuchs' Endothelial Corneal Dystrophy

    Mootha V, Hussain I, Cunnusamy K, Graham E, Gong X, Neelam S, Xing C, Kittler R, Petroll WM 2015 Mar 56 2003-2011

    Profilin-1 downregulation has contrasting effects on early vs late steps of breast cancer metastasis

    Ding Z, Joy M, Bhargava R, Gunsaulus M, Lakshman N, Miron-Mendoza M, Petroll M, Condeelis J, Wells A, Roy P 2014 Apr 33 2065-2074

    MMP regulation of corneal keratocyte motility and mechanics in 3-D collagen matrices

    Zhou C, Petroll WM 2014 Apr 121 147-160

    Pseudomonas aeruginosa infectious keratitis in a high oxygen transmissible rigid contact lens rabbit model

    Wei C, Zhu M, Matthew Petroll W, Robertson DM 2014 55 5890-5899

    The impact of type 1 diabetes mellitus on corneal epithelial nerve morphology and the corneal epithelium

    Cai D, Zhu M, Petroll WM, Koppaka V, Robertson DM 2014 184 2662-2670

    Cell-matrix interactions: New tools and fresh perspectives

    Petroll WM, Billiar KL 2013 Oct 319 2395

    Techniques for assessing 3-D cell-matrix mechanical interactions in vitro and in vivo

    Miron-Mendoza M, Koppaka V, Zhou C, Petroll WM 2013 Oct 319 2470-2480

    Quantitative 3-dimensional corneal imaging in vivo using a modified hrt-rcm confocal microscope

    Petroll WM, Weaver M, Vaidya S, McCulley JP, Cavanagh HD 2013 Apr 32 e36-e43

    Corneal epithelial cell viability following exposure to ophthalmic solutions containing preservatives and/or antihypertensive agents

    Whitson JT, Petroll WM 2012 Oct 29 874-888

    Individual versus collective fibroblast spreading and migration: Regulation by matrix composition in 3D culture

    Miron-Mendoza M, Lin X, Ma L, Ririe P, Petroll WM 2012 Jun 99 36-44

    Corneal stromal cells use both high- and low-contractility migration mechanisms in 3-D collagen matrices

    Kim A, Zhou C, Lakshman N, Petroll WM 2012 Apr 318 741-752

    Growth factor regulation of corneal keratocyte mechanical phenotypes in 3-D collagen matrices

    Lakshman N, Matthew Petroll W 2012 Mar 53 1077-1086

    A reconstituted telomerase-immortalized human corneal epithelium in vivo: A pilot study

    Robertson DM, Kalangara JP, Baucom RB, Petroll WM, Cavanagh HD 2011 Aug 36 706-712

    Comparative study of descemet stripping automated endothelial keratoplasty donor preparation by moria cbm microkeratome, horizon microkeratome, and intralase FS60

    Mootha V, Heck E, Verity S, Petroll WM, Lakshman N, Muftuoglu O, Bowman RW, McCulley JP, Cavanagh HD 2011 Mar 30 320-324

    Cell motility and mechanics in three-dimensional collagen matrices

    Grinnell F, Petroll WM 2010 Nov 26 335-361

    Castroviejo lecture 2009: 40 years in search of the perfect contact lens

    Cavanagh HD, Robertson DM, Petroll WM, Jester JV 2010 Oct 29 1075-1085

    Risk factors for intraocular pressure elevation after descemet stripping automated endothelial keratoplasty

    Allen MB, Lieu P, Mootha V, Bowman RW, Petroll WM, Tong L, Kooner KS, Cavanagh HD, Whitson JT, Aggarwal NK 2010 Jul 36 223-227

    Inducible macropinocytosis of hyaluronan in B16-F10 melanoma cells

    Greyner HJ, Wiraszka T, Zhang LS, Petroll WM, Mummert ME 2010 Jul 29 503-510

    Erratum: Rho kinase regulation of fibroblast migratory mechanics in fibrillar collagen matrices (Cellular and Molecular Bioengineering DOI: 10.1007/s12195-010-0106-2)

    Zhou C, Petroll WM 2010 Jun 3 195

    Rho kinase regulation of fibroblast migratory mechanics in fibrillar collagen matrices

    Zhou C, Petroll WM 2010 Mar 3 76-83

    Characterization of corneal keratocyte morphology and mechanical activity within 3-D collagen matrices

    Lakshman N, Kim A, Petroll WM 2010 Feb 90 350-359

    Growth factor regulation of corneal keratocyte differentiation and migration in compressed collagen matrices

    Kim A, Lakshman N, Karamichos D, Matthew Petroll W 2010 Feb 51 864-875

    Remote-Controlled scanning and automated confocal microscopy through focusing using a modified HRT rostock corneal module

    Petroll WM, Cavanagh HD 2009 Nov 35 302-308

    Erratum to "Quantitative assessment of local collagen matrix remodeling in 3-D culture: The role of Rho kinase" [Exp. Cell Res. 312 (2003) 3683-3692] (DOI:10.1016/j.yexcr.2006.08.009)

    Kim A, Lakshman N, Petroll WM 2009 Oct 315 3076

    Development of a hyaluronan bioconjugate for the topical treatment of melanoma

    Zhang LS, Petroll WM, Greyner HJ, Mummert ME 2009 Jul 55 56-59

    Tandem scanning confocal microscopy of cornea after descemet stripping automated endothelial keratoplasty

    Prasher P, Muftuoglu O, Bowman RW, McCulley JP, Petroll WM, Cavanagh HD, Mootha VV 2009 Jul 35 196-202

    Outcomes of PermaVision Intracorneal Implants for the Correction of Hyperopia

    Verity S, McCulley JP, Bowman RW, Cavanagh HD, Petroll WM 2009 Jun 147 973-977

    Intraocular pressure reduction in the untreated fellow eye after selective laser trabeculoplasty

    Rhodes KM, Weinstein R, Saltzmann RM, Aggarwal N, Kooner KS, Petroll WM, Whitson JT 2009 Mar 25 787-796

    Intraocular pressure reduction in the untreated fellow eye after selective laser trabeculoplasty

    Rhodes KM, Weinstein R, Saltzmann RM, Aggarwal N, Kooner KS, Petroll WM, Whitson JT 2009 Mar 25 787-796

    Technique article: An experimental model for assessing fibroblast migration in 3-D collagen matrices

    Karamichos D, Lakshman N, Petroll WM 2009 Jan 66 1-9

    Dynamic assessment of fibroblast mechanical activity during rac-induced cell spreading in 3-D culture

    Petroll WM, Ma L, Kim A, Ly L, Vishwanath M 2008 Oct 217 162-171

    Localized application of mechanical and biochemical stimuli in 3-D culture

    Petroll WM, Ma L 2008 Oct 237 2726-2736

    Assessment of keratocyte activation following lasik with flap creation using the intralase FS60 laser

    Petroll WM, Bowman RW, Cavanagh HD, Verity S, Mootha V, McCulley JP 2008 Oct 24 847-849

    Development of a hyaluronan targeted contrast reagent for the demarcation of melanoma margins in vivo [6]

    Rudrabhatla SR, Petroll WM, Mahaffey CL, Mummert ME 2008 Mar 128 740-742

    The effect of nonpreserved care solutions on 12 months of daily and extended silicone hydrogel contact lens wear

    Robertson DM, Petroll WM, Cavanagh HD 2008 Jan 49 7-15

    Analysis of the pattern of subcellular force generation by corneal fibroblasts after Rho activation

    Petroll WM, Ma L, Ly L, Vishwanath M 2008 Jan 34 65-70

    Quantitative assessment of corneal wound healing following intralasik using in vivo confocal microscopy

    McCulley JP, Petroll WM 2008 106 84-90

    Slit-lamp, confocal, and light microscopic findings of corneal siderosis

    Witherspoon SR, Hogan RN, Petroll WM, Mootha V 2007 Dec 26 1270-1272

    Regulation of corneal fibroblast morphology and collagen reorganization by extracellular matrix mechanical properties

    Karamichos D, Lakshman N, Petroll WM 2007 Nov 48 5030-5037

    The role of contact lens type, oxygen transmission, and care-related solutions in mediating epithelial homeostasis and Pseudomonas binding to corneal cells: An overview

    Robertson DM, Petroll WM, Jester JV, Cavanagh HD 2007 Nov 33 394-398

    Insulin-like Growth Factor Binding Protein-3 expression in the human corneal epithelium

    Robertson DM, Ho SI, Hansen BS, Petroll WM, Cavanagh HD 2007 Oct 85 492-501

    Microtubule regulation of corneal fibroblast morphology and mechanical activity in 3-D culture

    Kim A, Matthew Petroll W 2007 Oct 85 546-556

    Postnatal corneal transparency, keratocyte cell cycle exit and expression of ALDH1A1

    Jester JV, Lee YG, Huang J, Houston J, Adams B, Cavanagh HD, Petroll WM 2007 Sep 48 4061-4069

    Rho plays a central role in regulating local cell-matrix mechanical interactions in 3D culture

    Lakshman N, Kim A, Bayless KJ, Davis GE, Petroll WM 2007 Jun 64 434-445

    Current concepts: Contact lens related Pseudomonas keratitis

    Robertson DM, Petroll WM, Jester JV, Cavanagh HD 2007 May 30 94-107

    Comparison of the corneal response to laser in situ keratomileusis with flap creation using the FS15 and FS30 femtosecond lasers. Clinical and confocal microscopy findings

    Hu MY, McCulley JP, Cavanagh HD, Bowman RW, Verity S, Mootha V, Petroll WM 2007 Apr 33 673-681

    Prospective evaluation of PermaVision intracorneal implants using in vivo confocal microscopy

    Lindsey SS, McCulley JP, Cavanagh HD, Verity S, Bowman RW, Petroll WM 2007 Apr 23 410-413

    Local thermal injury elicits immediate dynamic behavioural responses by corneal Langerhans cells

    Ward BR, Jester JV, Nishibu A, Vishwanath M, Shalhevet D, Kumamoto T, Petroll WM, Cavanagh HD, Takashima A 2007 Apr 120 556-572

    Severe Reactive Ischemic Posterior Segment Inflammation in Acanthamoeba Keratitis. A New Potentially Blinding Syndrome

    Awwad ST, Heilman M, Hogan RN, Parmar DN, Petroll WM, McCulley JP, Cavanagh HD 2007 Feb 114 313-320

    Updates in Acanthamoeba keratitis

    Awwad ST, Petroll WM, McCulley JP, Cavanagh HD 2007 Jan 33 1-8

    Dynamic assessment of cell-matrix mechanical interactions in three-dimensional culture.

    Petroll WM 2007 370 67-82

    Quantitative assessment of local collagen matrix remodeling in 3-D Culture: The role of Rho kinase

    Kim A, Lakshman N, Petroll WM 2006 Nov 312 3683-3692

    Noninvasive corneal stromal collagen imaging using two-photon-generated second-harmonic signals

    Morishige N, Petroll WM, Nishida T, Kenney MC, Jester JV 2006 Nov 32 1784-1791

    Assessment of corneal epithelial integrity after acute exposure to ocular hypotensive agents preserved with and without benzalkonium chloride

    Whitson JT, Cavanagh HD, Lakshman N, Petroll WM 2006 Sep 23 663-671

    Regulation of Pseudomonas aeruginosa internalization after contact lens wear in vivo and in serum-free culture by ocular surface cells

    Yamamoto N, Yamamoto N, Petroll MW, Jester JV, Cavanagh HD 2006 Aug 47 3430-3440

    Evaluation of intrastromal lipid deposits after intacs implantation using in vivo confocal microscopy

    Ly LT, McCulley JP, Verity S, Cavanagh HD, Bowman RW, Petroll WM 2006 Jul 32 211-215

    Confocal assessment of the effects of fourth-generation fluoroquinolones on the cornea

    Ly LT, Cavanagh HD, Petroll WM 2006 Jul 32 161-165

    Confocal assessment of the corneal response to intracorneal lens insertion and laser in situ keratomileusis with flap creation using IntraLase

    Petroll WM, Goldberg D, Lindsey SS, Kelley PS, Cavanagh HD, Bowman RW, Parmar DN, Verity SM, McCulley JP 2006 Jul 32 1119-1128

    Prolonged hypoxia induces lipid raft formation and increases Pseudomonas internalization in vivo after contact lens wear and lid closure

    Yamamoto N, Yamamoto N, Jester JV, Petroll WM, Cavanagh HD 2006 May 32 114-120

    Tandem Scanning Confocal Corneal Microscopy in the Diagnosis of Suspected Acanthamoeba Keratitis

    Parmar DN, Awwad ST, Petroll WM, Bowman RW, McCulley JP, Cavanagh HD 2006 Apr 113 538-547

    Bcl-2 and Bax regulation of corneal homeostasis in genetically altered mice

    Robertson DM, Ladage PM, Yamamoto N, Jester JV, Petroll WM, Cavanagh HD 2006 Jan 32 3-7

    In-vivo microvasculature visualization using hyperspectral imaging

    Shah BB, Cavanagh HD, Petroll WM, Kothare AD, Gundabhat P, Behbehani K, Zuzak KJ 2006

    Differential interference contrast and confocal reflectance imaging of collagen organization in three-dimensional matrices

    Petroll WM 2006 28 305-310

    Real-time high spatial resolution, in vivo corneal imaging: Current successes and future needs

    Cavanagh HD, Petroll WM 2006

    Quantitative assessment of ophthalmic viscosurgical device retention using in vivo confocal microscopy

    Petroll WM, Jafari M, Lane SS, Jester JV, Cavanagh HD 2005 Dec 31 2363-2368

    Central corneal thickness in patients with congenital aniridia

    Whitson JT, Liang C, Godfrey DG, Petroll WM, Cavanagh HD, Patel D, Fellman RL, Starita RJ 2005 Sep 31 221-224

    Internalization of Pseudomonas aeruginosa is mediated by lipid rafts in contact lens-wearing rabbit and cultured human corneal epithelial cells

    Yamamoto N, Yamamoto N, Petroll WM, Cavanagh HD, Jester JV 2005 Apr 46 1348-1355

    Corneal fibroblasts respond rapidly to changes in local mechanical stress

    Petroll WM, Vishwanath M, Ma L 2004 Oct 45 3466-3474

    Pseudomonas aeruginosa corneal binding after 24-hour orthokeratology lens wear

    Ladage PM, Yamamoto N, Robertson DM, Jester JV, Petroll WM, Cavanagh HD 2004 Jul 30 173-178

    Evaluation of the corneal effects of topical ophthalmic fluoroquinolones using in vivo confocal microscopy

    Kovoor TA, Kim AS, McCulley JP, Cavanagh HD, Jester JV, Bugde AC, Petroll WM 2004 Apr 30 90-94

    Four-dimensional multiphoton confocal microscopy: The new frontier in cellular imaging

    Jester JV, Ward BR, Takashima A, Gatlin J, Garcia JV, Cavanagh HD, Petroll WM 2004 Jan 2 10-20

    Dynamic Three-Dimensional Visualization of Collagen Matrix Remodeling and Cytoskeletal Organization in Living Corneal Fibroblasts

    Petroll WM, Cavanagh HD, Jester JV 2004 26 1-10

    Effect of ophthalmic viscosurgical devices on lens epithelial cells: A morphological study

    Budo C, Goffinet G, Bellotto D, Petroll WM 2003 Dec 29 2411-2418

    Modulation of Corneal Fibroblast Contractility within Fibrillar Collagen Matrices

    Vishwanath M, Ma L, Otey CA, Jester JV, Petroll WM 2003 Nov 44 4724-4735

    Direct, dynamic assessment of cell-matrix interactions inside fibrillar collagen lattices

    Petroll WM, Ma L 2003 Aug 55 254-264

    Effects of eyelid closure and disposable and silicone hydrogel extended contact lens wear on rabbit corneal epithelial proliferation

    Ladage PM, Ren DH, Petroll WM, Jester JV, Bergmanson JP, Cavanagh HD 2003 May 44 1843-1849

    Direct correlation of collagen matrix deformation with focal adhesion dynamics in living corneal fibroblasts

    Petroll WM, Ma L, Jester JV 2003 Apr 116 1481-1491

    Recovery time of corneal epithelial proliferation in the rabbit following rigid gas-permeable extended contact-lens wear

    Ladage PM, Yamamoto K, Ren DH, Jester JV, Petroll WM, Bergmanson JP, Cavanagh HD 2003 Apr 29 61-64

    In vivo fluorescent labeling of corneal wound healing fibroblasts

    Gatlin J, Melkus MW, Padgett A, Petroll WM, Cavanagh HD, Garcia JV, Jester JV 2003 Mar 76 361-371

    Vertical movement of epithelial basal cells toward the corneal surface during use of extended-wear contact lenses

    Ladage PM, Jester JV, Petroll WM, Bergmanson JP, Cavanagh HD 2003 Mar 44 1056-1063

    Neonatal corneal stromal development in the normal and lumican-deficient mouse

    Song J, Lee YG, Houston J, Petroll WM, Chakravarti S, Cavanagh HD, Jester JV 2003 Feb 44 548-557

    Can postlens tear thickness be measured using three-dimensional in vivo confocal microscopy?

    Petroll WM, Kovoor T, Ladage PM, Cavanagh HD, Jester JV, Robertson DM 2003 Jan 29 S110-114; discussion S115-118, S192-194

    Role of oxygen in corneal epithelial homeostasis during extended contact lens wear.

    Ladage PM, Jester JV, Petroll WM, Bergmanson JP, Cavanagh HD 2003 Jan 29 S2-6; discussion S26-29, S192-194

    Effects of daily and overnight wear of hyper-oxygen transmissible rigid and silicone hydrogel lenses on bacterial binding to the corneal epithelium: 13-month clinical trials.

    Cavanagh HD, Ladage P, Yamamoto K, Li SL, Petroll WM, Jester JV 2003 Jan 29 S14-16; discussion S26-29, S192-194

    Effects of contact lens care solutions on surface exfoliation and bacterial binding to corneal epithelial cells

    Li SL, Ladage PM, Yamamoto T, Petroll WM, Jester JV, Cavanagh HD 2003 Jan 29 27-30

    Effects of daily and overnight wear of a novel hyper oxygen-transmissible soft contact lens on bacterial binding and corneal epithelium: A 13-month clinical trial

    Cavanagh HD, Ladage PM, Li SL, Yamamoto K, Molai M, Ren DH, Petroll WM, Jester JV 2002 Nov 109 1957-1969

    Spherical Indentations of Human and Rabbit Corneal Epithelium Following Extended Contact Lens Wear

    Ladage PM, Petroll WM, Jester JV, Fisher S, Bergmanson JP, Cavanagh HD 2002 Oct 28 177-180

    Intraocular pressure measurement after hyperopic LASIK.

    Wang SX, Shen J, McCulley JP, Bowman RW, Petroll WM, Cavanagh HD 2002 Jul 28 136-139

    In vivo confocal microscopy through-focusing to measure corneal flap thickness after laser in situ keratomileusis

    Gokmen F, Jester JV, Petroll WM, McCulley JP, Cavanagh HD 2002 28 962-970

    Corneal epithelial homeostasis following daily and overnight contact lens wear

    Ladage PM, Yamamoto K, Li L, Ren DH, Petroll WM, Jester JV, Cavanagh HD 2002 25 11-21

    TGFβ induced myofibroblast differentiation of rabbit keratocytes requires synergistic TGFβ, PDGF and integrin signaling

    Jester JV, Huang J, Petroll WM, Cavanagh HD 2002 75 645-657

    Annexin V binding to rabbit corneal epithelial cells following overnight contact lens wear or eyelid closure

    Li L, Ren DH, Ladage PM, Yamamoto K, Petroll WM, Jester JV, Cavanagh HD 2002 28 48-54

    Regulation of endotoxin-induced keratitis by PECAM-1, MIP-2, and toll-like receptor 4

    Khatri S, Lass JH, Heinzel FP, Petroll WM, Gomez J, Diaconu E, Kalsow CM, Pearlman E 2002 43 2278-2284

    A prototype two-detector confocal microscope for in vivo corneal imaging

    Petroll WM, Yu A, Li J, Jester JV, Cavanagh HD, Black T 2002 24 163-170

    Effect of eyelid closure and overnight contact lens wear on viability of surface epithelial cells in rabbit cornea

    Yamamoto K, Ladage PM, Ren DH, Li L, Petroll WM, Jester JV, Cavanagh HD 2002 21 85-90

    Effects of O2 transmissibility on corneal epithelium after daily and extended contact lens wear in rabbit and man

    Ladage PM, Yamamoto K, Li L, Ren DH, Petroll WM, Jester JV, Cavanagh HD 2002 506 B 885-893

    Adaptive effects of 30-night wear of hyper-O2 transmissible contact lenses on bacterial binding and corneal epithelium: A 1-year clinical trial

    Ren DH, Yamamoto K, Ladage PM, Molai M, Li L, Petroll WM, Jester JV, Cavanagh HD 2002 109 27-39

    Pathology of ocular irritation with acetone, cyclohexanol, parafluoroaniline, and formaldehyde in the rabbit low-volume eye test

    Maurer JK, Molai A, Parker RD, Li L, Carr GJ, Petroll WM, Cavanagh HD, Jester JV 2001 Feb 29 187-199

    Surgically induced astigmatism after hyperopic and myopic photorefractive keratectomy

    Yi DH, Petroll WM, Bowman RW, McCulley JP, Cavanagh HD 2001 27 396-403

    Corneal haze after photorefractive keratectomy using different epithelial removal techniques: Mechanical debridemen versus laser scrape

    Lee YG, Chen WY, Petroll WM, Cavanagh HD, Jester JV 2001 108 112-120

    A novel non-invasive, in vivo technique for the quantification of leukocyte rolling and extravasation at sites of inflammation in human patients

    Kirveskari J, Vesaluoma MH, Moilanen JA, Tervo TM, Petroll MW, Linnolahti E, Renkonen R 2001 7 376-379

    Proliferation rate of rabbit corneal epithelium during overnight rigid contact lens wear

    Ladage PM, Yamamoto K, Ren DH, Li L, Jester JV, Petroll WM, Bergmanson JP, Cavanagh HD 2001 42 2804-2812

    Effects of low and hyper Dk rigid gas permeable contact lenses on Bcl-2 expression and apoptosis in the rabbit corneal epithelium

    Yamamoto K, Ladage PM, Ren DH, Li L, Petroll WM, Jester JV, Cavanagh HD 2001 27 137-143

    Organization of junctional proteins in proliferating cat corneal endothelium during wound healing

    Petroll WM, Ma L, Jester JV, Cavanagh HD, Bean J 2001 20 73-80

    Measurement of corneal sublayer thickness and transparency in transgenic mice with altered corneal clarity using in vivo confocal microscopy

    Jester JV, Ghee Lee Y, Li J, Chakravarti S, Paul J, Petroll WM, Cavanagh HD 2001 41 1283-1290

    Bcl-2 expression in the human cornea

    Yamamoto K, Ladage PM, Ren DH, Li L, Petroll WM, Jester JV, Cavanagh HD 2001 73 247-255

    Pathology of ocular irritation with bleaching agents in the rabbit low-volume eye test

    Maurer JK, Molai A, Parker RD, Li L, Carr GJ, Petroll WM, Cavanagh HD, Jester JV 2001 29 308-319

    Effects of rigid and soft contact lens daily wear on corneal epithelium, tear lactate dehydrogenase, and bacterial binding to exfoliated epithelial cells

    Ladage PM, Yamamoto K, Ren DH, Li L, Jester JV, Petroll WM, Cavanagh HD 2001 108 1279-1288

    Confocal microscopy of a patient with irregular astigmatism after LASIK reoperations and relaxation incisions

    Linna TU, Vesaluoma MH, Petroll WM, Tarkkanen AH, Tervo TM 2000 Mar 19 163-169

    In vivo confocal microscopy of patients with corneal recurrent erosion syndrome or epithelial basement membrane dystrophy

    Rosenberg ME, Tervo TM, Petroll WM, Vesaluoma MH 2000 Mar 107 565-573

    Effect of myopic LASIK on corneal sensitivity and morphology of subbasal nerves

    Linna TU, Vesaluoma MH, Pérez-Santonja JJ, Petroll WM, Alió JL, Tervo TM 2000 Feb 41 393-397

    Corneal stromal changes induced by myopic LASIK

    Vesaluoma M, Pérez-Santonja J, Petroll WM, Linna T, Alió J, Tervo T 2000 41 369-376

    Specular microscopy, confocal microscopy, and ultrasound biomicroscopy: Diagnostic tools of the past quarter century

    Cavanagh HD, El-Agha MS, Petroll WM, Jester JV 2000 19 712-722

    Effect of eyelid closure on the epithelial proliferation rate of the rabbit cornea

    Ladage PM, Yamamoto K, Li L, Petroll M, Jester JV, Bergmanson JP, Cavanagh HD 2000 77 173

    Quantitative characterization of acid- and alkali-induced corneal injury in the low-volume eye test

    Jester JV, Molai A, Petroll WM, Parker RD, Carr GJ, Cavanagh HD, Maurer JK 2000 28 668-678

    Corneal opacity in lumican-null mice: Defects in collagen fibril structure and packing in the posterior stroma

    Chakravarti S, Petroll WM, Hassell JR, Jester JV, Lass JH, Paul J, Birk DE 2000 41 3365-3373

    Laser in situ keratomileusis flap margin: Wound healing and complications imaged by in vivo confocal microscopy

    Vesaluoma MH, Petroll WM, Pérez-Santonja JJ, Valle TU, Alió JL, Tervo TM 2000 130 564-573

    On-line 3-dimensional confocal imaging in vivo

    Li J, Jester JV, Cavanagh HD, Black TD, Petroll WM 2000 41 2945-2953

    Autosomal recessive cornea plana: In vivo corneal morphology and corneal sensitivity

    Vesaluoma MH, Sankila EM, Gallar J, Müller LJ, Petroll WM, Moilanen JA, Forsius H, Tervo TM 2000 41 2120-2126

    Stromal wound healing explains refractive instability and haze development after photorefractive keratectomy: A 1-year confocal microscopic study

    Moller-Pedersen T, Cavanagh HD, Petroll WM, Jester JV 2000 107 1235-1245

    Comparison of contractile force generated by isolated and paired fibroblasts in vitro

    Mariappan MR, Petroll WM, Cavanagh HD, Jester JV 1999 Dec

    Changes in corneal endothelial apical junctional protein organization after corneal cold storage

    Hsu JK, Cavanagh HD, Jester JV, Ma L, Petroll WM 1999 Nov 18 712-720

    Transforming growth factor(β)-mediated corneal myofibroblast differentiation requires actin and fibronectin assembly

    Jester JV, Huang J, Barry-Lane PA, Kao WW, Petroll WM, Cavanagh HD 1999 Aug 40 1959-1967

    The application of in vivo confocal microscopy and tear LDH measurement in assessing corneal response to contact lens and contact lens solutions

    Chang JH, Ren H, Petroll WM, Cavanagh HD, Jester JV 1999 Aug 19 171-181

    Quantitative measurement of acute corneal injury in rabbits with surfactants of different type and irritancy

    Maurer JK, Parker RD, Petroll WM, Carr GJ, Cavanagh HD, Jester JV 1999 Jul 158 61-70

    Corneal stromal wound healing in refractive surgery: The role of myofibroblasts

    Jester JV, Petroll WM, Cavanagh HD 1999 Jul 18 311-356

    The effect of rigid gas permeable contact lens wear on proliferation of rabbit corneal and conjunctival epithelial cells

    Ren DH, Petroll WM, Jester JV, Cavanagh HD 1999 Jul 25 136-141

    The relationship between contact lens oxygen permeability and binding of Pseudomonas aeruginosa to human corneal epithelial cells after overnight and extended wear

    Ren DH, Petroll WM, Jester JV, Ho-Fan J, Cavanagh HD 1999 Apr 25 80-100

    Short-term hypoxia downregulates epithelial cell desquamation in vivo, but does not increase Pseudomonas aeruginosa adherence to exfoliated human corneal epithelial cells

    Ren DH, Petroll WM, Jester JV, Ho-Fan J, Cavanagh HD 1999 Apr 25 73-79

    The spatial organization of apical junctional complex-associated proteins in feline and human corneal endothelium

    Petroll WM, Hsu JK, Bean J, Cavanagh HD, Jester JV 1999 Jan 18 10-19

    Exertion of tractional force requires the coordinated up-regulation of cell contractility and adhesion

    Roy P, Petroll WM, Cavanagh HD, Jester JV 1999 43 23-34

    Effect of Cell Migration on the Maintenance of Tension on a Collagen Matrix

    Roy P, Petroll WM, Chuong CJ, Cavanagh HD, Jester JV 1999 27 721-730

    Labeling of cycling corneal endothelial cells during healing with a monoclonal antibody to the Ki67 antigen (MIB-1)

    Petroll WM, Jester JV, Bean J, Cavanagh HD 1999 18 98-108

    Measurement of tissue thickness using confocal microscopy

    Jester JV, Petroll WM, Cavanagh HD 1999 307 230-245

    On-line 3-dimensional confocal imaging in vivo

    Li J, Jester JV, Cavanagh HD, Petroll WM 1999 1088

    The cellular basis of corneal transparency: Evidence for 'corneal crystallins'

    Jester JV, Moller-Pedersen T, Huang J, Sax CM, Kays WT, Cavangh HD, Petroll WM, Piatigorsky J 1999 112 613-622

    Area and depth of surfactant-induced corneal injury predicts extent of subsequent ocular responses

    Jester JV, Petroll WM, Bean J, Parker RD, Carr GJ, Cavanagh HD, Maurer JK 1998 Dec 39 2610-2625

    Myofibroblast transformation of cat corneal endothelium by transforming growth factor-β1, -β2, and -β3

    Petroll WM, Jester JV, Bean JJ, Cavanagh HD 1998 Oct 39 2018-2032

    Neutralizing antibody to TGFβ modulates stromal fibrosis but not regression of photoablative effect following PRK

    Møller-Pedersen T, Cavanagh HD, Petroll WM, Jester JV 1998 Jul 17 736-747

    Area and depth of surfactant-induced corneal injury correlates with cell death

    Jester JV, Li HF, Petroll WM, Parker RD, Cavanagh HD, Carr GJ, Smith B, Maurer JK 1998 May 39 922-936

    Confocal microscopic characterization of wound repair after photorefractive keratectomy

    Møller-Pedersen T, Li HF, Petroll WM, Cavanagh HD, Jester JV 1998 Mar 39 487-501

    Assessment of stress fiber orientation during healing of radial keratotomy wounds using confocal microscopy

    Petroll WM, Cavanagh HD, Jester JV 1998 Mar 20 74-82

    Corneal haze development after PRK is regulated by volume of stromal tissue removal

    Møller-Pedersen T, Cavanagh HD, Petroll WM, Jester JV 1998 17 627-639

    Clinical confocal microscopy

    Petroll WM, Cavanagh HD, Jester JV 1998 9 59-65

    Characterization of specular 'dark events' in human donor corneal endothelium by scanning and transmission electron microscopy

    Nartey IN, Cavanagh HD, Jester JV, Andrews P, Petroll WM 1998 17 544-549

    An in vitro force measurement assay to study the early mechanical interaction between corneal fibroblasts and collagen matrix

    Roy P, Petroll WM, Cavanagh HD, Chuong CJ, Jester JV 1997 Apr 232 106-117

    Confocal microscopic characterization of initial corneal changes of surfactant-induced eye irritation in the rabbit

    Maurer JK, Li HF, Petroll WM, Parker RD, Cavanagh HD, Jester JV 1997 Apr 143 291-300

    Inhibition of corneal fibrosis by topical application of blocking antibodies to TGF(β) in the rabbit

    Jester JV, Barry-Lane PA, Petroll WM, Olsen DR, Cavanagh HD 1997 Mar 16 177-187

    ZO-1 reorganization and myofibroblast transformation of corneal endothelial cells after freeze injury in the cat

    Petroll WM, Barry-Lane PA, Cavanagh HD, Jester JV 1997 Feb 64 257-267

    Collagen fiber architecture of a cultured dermal tissue

    Sacks MS, Chuong CJ, Petroll WM, Kwan M, Halberstadt C 1997 Feb 119 124-127

    Adherence of Pseudomonas aeruginosa to shed rabbit corneal epithelial cells after overnight wear of contact lenses

    Ren H, Petroll WM, Jester JV, Cavanagh HD, Mathers WD, Bonanno JA, Kennedy RH 1997 Jan 23 63-68

    Characterization of SV40-transfected cell strains from rabbit keratocytes

    Barry-Lane PA, Wilson SE, Cavanagh HD, Petroll WM, Jester JV 1997 Jan 16 72-78

    Epithelial and corneal thickness measurements by in vivo confocal microscopy through focusing (CMTF)

    Li HF, Petroll WM, Møller-Pedersen T, Maurer JK, Cavanagh HD, Jester JV 1997 16 214-221

    Area and depth of surfactant-induced corneal injury correlates with cell death

    Li TF, Maurer JK, Parker RD, Petroll WM, Cavanagh HD, Jester JV 1997 38 S399

    Anti-TGFβ treatment reduces corneal haze but not regression of ablative effict following excimer laser prk in the rabbit

    Moller-Pedersen T, Li HF, Petroll WM, Cavanagh HD, Jester JV 1997 38 S209

    Tgfβ mediated corneal myofibroblast transformation is dependent on tyrosine phosphorylation

    Jester JV, Huang J, Kao WW, Petroll WM, Cavanagh HD 1997 38 S502

    Quantification of stromal thinning, epithelial thickness, and corneal haze after photorefractive keratectomy using in vivo confocal microscopy

    Moller-Pedersen T, Vogel M, Hong Fang Li FL, Petroll WM, Cavanagh HD, Jester JV 1997 104 360-368

    Does hypoxia alone increase the bacterial adherence to exfoliated corneal epithelial cells in man?

    Ren H, Ho-Fan J, Petroll WM, Jester JV, Cavanagh HD 1997 38 S139

    In vivo confocal microscopy: a new possibility to confirm the diagnosis of Borrelia keratitis?

    Linna T, Mikkilä H, Karma A, Seppälä I, Petroll WM, Tervo T 1996 Nov 15 639-640

    Application of In Vivo Confocal Microscopy to the Understanding of Surfactant-Induced Ocular Irritation*Oryzias latipes

    Jester JV, Maurer JK, Petroll WM, Wilkie DA, Parker RD, Cavanagh HD 1996 Jul 24 412-428

    Computational models of the effects of hydration on corneal biomechanics and the results of radial keratotomy

    Roy P, Petroll WM, McKinney AE, Chuong CJ 1996 May 118 255-258

    TGFβ1 modulated myofibroblast transformation via matrix interaction: Role in wound contraction

    Jester JV, Petroll WM, Huang J, Roy P, Barry-Lane PA, Cavanagh HD 1996 Feb 37 S219

    Induction of α-smooth muscle actin expression and myofibroblast transformation in cultured corneal keratocytes

    Jester JV, Barry-Lane PA, Cavanagh HD, Petroll WM 1996 15 505-516

    Measurement of Surgically Induced Corneal Deformations Using Three-Dimensional Confocal Microscopy

    Petroll WM, Roy P, Chuong CJ, Hall B, Cavanagh HD, Jester JV 1996 15 154-164

    Effects of basic FGF and TGF(β1) on F-actin and ZO-1 organization during cat endothelial wound healing

    Petroll WM, Jester JV, Barry-Lane PA, Cavanagh HD 1996 15 525-532

    Quantitative three-dimensional confocal imaging of the cornea in situ and in vivo: System design and calibration

    Petroll WM, Jester JV, Cavanagh HD 1996 18 45-49

    In vivo confocal imaging.

    Petroll WM, Jester JV, Cavanagh HD 1996 36 93-129

    Basic science and applications of in vivo microscopy

    Mathers WD, Petroll WM, Jester JV, Cavanagh HD 1995 6 86-94

    The spatial organization of corneal endothelial cytoskeletal proteins and their relationship to the apical junctional complex

    Barry PA, Petroll WM, Andrews PM, Cavanagh HD, Jester JV 1995 36 1115-1124

    Expression of α-smooth muscle (α-SM) actin during corneal stromal wound healing

    Jester JV, Petroll WM, Barry PA, Cavanagh HD 1995 36 809-819

    Temporal, 3-dimensional, cellular anatomy of corneal wound tissue

    Jester JV, Petroll WM, Barry PA, Cavanagh HD 1995 186 301-311

    Assessment of F-actin organization and apical-basal polarity during in vivo cat endothelial wound healing

    Petroll WM, Jester JV, Barry-Lane P, Cavanagh HD 1995 36 2492-2502

    Quantitative assessment of anteroposterior keratocyte density in the normal rabbit cornea

    Petroll WM, Boettcher K, Barry P, Cavanagh D, Jester JV 1995 14 3-9

    Confocal microscopy: Uses in measurement of cellular structure and function

    Cavanagh HD, Petroll WM, Jester JV 1995 14 527-565

    The effects of daily wear of rigid gas permeable contact lenses treated with contact lens care solutions containing preservatives on the rabbit cornea

    Imayasu M, Moriyama T, Ichijima H, Ohashi JI, Petroll WM, Jester JV, Cavanagh HD 1994 Jul 20 183-188

    Corneal keratocytes: In situ and in vitro organization of cytoskeletal contractile proteins

    Jester JV, Barry PA, Lind GJ, Petroll WM, Garana R, Cavanagh HD 1994 Jan 35 730-743

    Three and four dimensional scanning microscopy: Introduction

    Cavanagh HD, Petroll WM, Jester JV 1994 16 129

    Laser and tandem scanning confocal microscopic studies of rabbit corneal wound healing

    Ichijima H, Jester JV, Petroll WM, Cavanagh HD 1994 16 263-268

    The future development of confocal microscopy

    Cavanagh HD, Jester JV, Petroll WM 1994 16 261

    In vivo confocal imaging: General principles and applications

    Petroll WM, Jester JV, Cavanagh HD 1994 16 131-149

    The Relation between Contact Lens Oxygen Transmissibility and Binding of Pseudomonas aeruginosa to the Cornea after Overnight Wear

    Imayasu M, Petroll WM, Jester JV, Patel SK, Ohashi JI, Cavanagh HD 1994 101 371-388

    In vivo osmotic pertubation of intercellular fluid channels in the rabbit corneal endothelium

    Andrews PM, Jester JV, Petroll WM, Barry PA, Ichijima H, Cavanagh HD 1994 13 253-258

    Three‐dimensional imaging of corneal cells using in vivo confocal microscopy

    Petroll WM, Cavanagh HD, Jester JV 1993 Jun 170 213-219

    Quantitative analysis of stress fiber orientation during corneal wound contraction

    Petroll WM, Cavanagh HD, Barry P, Andrews P, Jester JV 1993 Feb 104 353-363

    The application of confocal microscopy to the study of living systems

    Cavanagh HD, Petroll WM, Jester JV 1993 Jan 17 483-498

    Ocular water evaporation and the dry eye: A new measuring device

    Mathers WD, Binarao G, Petroll M 1993 Jan 12 335-340

    Clinical and Diagnostic Use of In Vivo Confocal Microscopy in Patients with Corneal Disease

    Cavanagh HD, Petroll WM, Alizadeh H, He Y, McCulley JP, Jester JV 1993 100 1444-1454

    Morphological and biochemical evaluation for rigid gas permeable contact lens extended wear on rabbit corneal epithelium

    Ichijima H, Ohashi JI, Petroll WM, Cavanagh HD 1993 19 121-128

    Methods in laboratory investigation: Noninvasive microscopic evaluation of the intact living nephrotic kidney

    Pulver M, Petroll WM, Andrews PM 1993 68 592-596

    In vivo confocal microscopic studies of endothelial wound healing in rabbit cornea

    Ichijima H, Petroll WM, Jester JV, Barry PA, Andrews PM, Dai M, Cavanagh HD 1993 12 369-378

    The application of confocal microscopy to the study of living systems

    Cavanagh HD, Petroll WM, Jester JV 1993 17 477-482

    Actin filament organization during endothelial wound healing in the rabbit cornea: Comparison between transcorneal freeze and mechanical scrape injuries

    Ichijima H, Petroll WM, Barry PA, Andrews PM, Dai M, Cavanagh HD, Jester JV 1993 34 2803-2812

    In vivo confocal microscopy in clinical dental research: An initial appraisal

    Watson TF, Petroll WM, Cavanagh HD, Jester JV 1992 Dec 20 352-358

    Erratum: Confocal microscopic studies of living rabbit cornea treated with benzalkonium chloride (Cornea (1992) 11:3 (221-225))

    Ichijima H, Petroll WM, Jester JV, Cavanagh HD 1992 Jul 11

    Morphologic effects of contact lens wear on the corneal surface

    Mathers WD, Sachdev MS, Petroll M, Lemp MA 1992 Jan 18 49-52

    Comparison of in vivo and ex vivo cellular structure in rabbit eyes detected by tandem scanning microscopy

    Jester JV, Petroll WM, Garana RM, Lemp MA, Cavanagh HD 1992 Jan 165 169-181

    Digital image acquisition in in vivo confocal microscopy

    Petroll WM, Cavanagh HD, Lemp MA, Andrews PM 1992 Jan 165 61-69

    Radial keratotomy: I. The wound healing process and measurement of incisional gape in two animal models using in vivo confocal microscopy

    Jester JV, Petroll WM, Feng W, Essepian J, Cavanagh HD 1992 33 3255-3270

    Radial keratotomy: II. Role of the myofibroblast in corneal wound contraction

    Garana RM, Petroll WM, Chen WT, Herman IM, Barry P, Andrews P, Cavanagh HD, Jester JV 1992 33 3271-3282

    Effects of increasing Dk with rigid contact lens extended wear on rabbit corneal epithelium using confocal microscopy

    Ichijima H, Petroll WM, Jester JV, Ohashi JI, Cavanagh HD 1992 11 282-287

    Radial keratotomy: III. Relationship between wound gape and corneal curvature in primate eyes

    Petroll WM, New K, Sachdev M, Cavanagh HD, Jester JV 1992 33 3283-3291

    Confocal microscopic studies of living rabbit cornea treated with benzalkonium chloride

    Ichijima H, Petroll WM, Jester JV, Cavanagh HD 1992 11 221-225

    Tandem Scanning Confocal Microscopy (TSCM) of normal and ischemic living kidneys

    Andrews PM, Petroll WM, Cavanagh HD, Jester JV 1991 May 191 95-102

    In vivo, realtime confocal imaging

    Jester JV, Andrews PM, Petroll WM, Lemp MA, Cavanagh HD 1991 May 18 50-60

    Relationships between abdominal and diaphragmatic volume displacements

    Knight H, Petroll WM, Rochester DF 1991 Jan 71 565-572

    Meibomian gland morphology and tear osmolarity: Changes with accutane therapy

    Mathers WD, Shields WJ, Sachdev MS, Petroll WM, Jester JV 1991 Jan 10 286-290

    In vitro artifacts vs in vivo reality with confocal microscopy

    Jester JV, Petroll WM, Garana R, Lemp MA, Cavanagh HD 1991 13 I91-I92

    Meibomian gland dysfunction in chronic blepharitis

    Mathers WD, Shields WJ, Sachdev MS, Petroll WM, Jester JV 1991 10 277-285

    In vivo imaging of human teeth and skin using real‐time confocal microscopy

    New KC, Petroll WM, Boyde A, Martin L, Corcuff P, Leveque JL, Lemp MA, Cavanagh HD, Jester JV 1991 13 369-372

    In vivo 3-dimensional reconstruction of corneal fibroblasts using confocal microscopy

    Petroll WM, Hill J, Cavanagh HD, Jester JV 1991 13 I92-I93

    Tandem scanning confocal microscopy of the living kidney

    Andrews PM, Petroll WM, Cavanagh HD, Jester JV 1991 13 I100-I101

    Fluorescent staining of intact, unsectioned corneal tissue for analysis by confocal microscopy

    Barry PA, Petroll WM, Garana RM, Cavanagh HD, Jester JV 1991 13 I112

    A model approach to assess diaphragmatic volume displacement

    Petroll WM, Knight H, Rochester DF 1990 69 2175-2182

    Videofluoroscopic assessment of muscle fiber shortening in the in situ canine diaphragm

    Knight H, Petroll WM, Adams JM, Shaffer HA, Rochester DF 1990 68 2200-2207

    Effect of lower rib cage expansion and diaphragm shortening on the zone of apposition

    Petroll WM, Knight H, Rochester DF 1990 68 484-488

    Contact Petroll Lab

    We want to hear from students and postdoctoral candidates who are interested in joining our lab. Please contact us for more information.

    W. Matthew Petroll, Ph.D. 
    Professor of Ophthalmology Vice Chair, Research
    Chair, Biomedical Engineering Graduate Program
    Email

    Mailing Address
    Department of Ophthalmology
    UT Southwestern Medical Center
    5323 Harry Hines Blvd.
    Dallas, TX 75390-9057

     

    Dr. Petroll and his four lab members. l. to r.: Kate Borner (BME grad student), Miguel Miron Mendoza, Ph.D. (Sr. Research Scientist), W. Matthew Petroll, Ph.D., Hajar Hassaniardekani, Ph.D. (Postdoc), and Kara Poole (BME grad student)