Publications

Dynamic Expansion and Contraction of Multiple Sclerosis T2-Weighted Hyperintense Lesions Are Present below the Threshold of Visual Perception

Okuda DT, Moog TM, McCreary M, Shan K, Zubkow K, Newton BD, Smith AD, Patel MA, Burgess KW, Lebrun-Frénay C 2025 Feb American Journal of Neuroradiology 46 443-450

Analysis of healthcare utilization before the diagnosis of radiologically isolated syndrome

Lebrun-Frenay C, Kerbrat S, Okuda DT, Landes-Chateau C, Kantarci OH, Pierret C, Drezen E, Nowak E, Siva A, Azevedo CJ, Cohen M, Leray E 2025 Feb Multiple Sclerosis Journal 31 184-196

Faster and better than a physician?: Assessing diagnostic proficiency of ChatGPT in misdiagnosed individuals with neuromyelitis optica spectrum disorder

Shan K, Patel MA, McCreary M, Punnen TG, Villalobos F, Tardo LM, Horton LA, Sguigna PV, Blackburn KM, Munoz SB, Burgess KW, Moog TM, Smith AD, Okuda DT 2025 Jan Journal of the Neurological Sciences 468

Transforming grayscale MRI images to color utilizing generative artificial intelligence to better understand multiple sclerosis

Okuda DT, Lebrun-Frénay C 2025 Jan Journal of Central Nervous System Disease 17

Time to move past typical syndromes in the diagnosis of multiple sclerosis

Lebrun-Frenay C, Okuda DT 2024 Oct Multiple Sclerosis Journal 30 1570-1572

Dimethyl fumarate preserves brainstem and cervical spinal cord integrity in radiologically isolated syndrome

Author Collaboration ob, Okuda DT, Azevedo CJ, Pelletier D, Moog TM, Moazami S, Rezvani S, Bovis F, Sormani MP, Siva A, Kantarci O, Lebrun-Frénay C, Vargas WS, Stüve O, Repovic P, Pardo G, Okuda DT, Okai A, Naismith RT, Mowry EM, Hua LH, Donlon S, Azevedo CJ, Amezcua L 2024 Sep Journal of neurology 271 5899-5910

Underdosed generic specialty medications: A prescription for patient harm?

Okuda DT, Burgess KW, Moog TM, Patel MA 2024 Aug Multiple Sclerosis and Related Disorders 88

The diagnostic workup of children with the radiologically isolated syndrome differs by age and by sex

Author Collaboration ob, Makhani N, Lebrun-Frenay C, Siva A, Shabanova V, Wassmer E, Santoro JD, Narula S, Brenton JN, Mar S, Durand-Dubief F, Zephir H, Mathey G, Rojas JI, de Seze J, Tenembaum S, Stone RT, Casez O, Carra-Dallière C, Neuteboom RF, Ahsan N, Arroyo HA, Cabre P, Gombolay G, Inglese M, Louapre C, Margoni M, Palavra F, Pohl D, Reich DS, Ruet A, Thouvenot E, Timby N, Tintore M, Uygunoglu U, Vargas W, Venkateswaran S, Verhelst H, Wickstrom R, Azevedo CJ, Kantarci O, Shapiro ED, Okuda DT, Pelletier D 2024 Jul Journal of neurology 271 4019-4027

Radiologically isolated syndrome in the spectrum of multiple sclerosis

Okuda DT 2024 May Multiple Sclerosis Journal 30 630-636

The diagnostic value of the central vein sign in radiologically isolated syndrome

Landes-Chateau C, Levraut M, Okuda DT, Themelin A, Cohen M, Kantarci OH, Siva A, Pelletier D, Mondot L, Lebrun-Frenay C 2024 Mar Annals of Clinical and Translational Neurology 11 662-672

Reduced resting beat-to-beat blood pressure variability in females with relapsing-remitting multiple sclerosis

Kissell CE, Young BE, Jarrard CP, Huang M, Allen DR, Okuda DT, Smith SA, Fadel PJ, Davis SL 2024 Mar Multiple Sclerosis and Related Disorders 83

Clinical and radiological implications of subpotent generic fingolimod in multiple sclerosis: a case series

Okuda DT, Tardo LM, Wright CM, Munoz SB, Punnen TG, Patel MA, Moog TM, Burgess KW 2024 Jan Therapeutic Advances in Neurological Disorders 17

Costs of Potential Medication Wastage Due to Switching Treatment Among People With Multiple Sclerosis

Okuda DT, Patel A, Schuldt R, Abioye I, Bonine NG 2024 Journal of Health Economics and Outcomes Research 11 103-108

Investigating the link between regional oxygen metabolism and cognitive speed in multiple sclerosis: Implications for fatigue

Zuppichini MD, Sivakolundu DK, West KL, Okuda DT, Rypma B 2023 Dec Multiple Sclerosis and Related Disorders 80

Reply: Do we need new MRI criteria for the diagnosis of radiologically isolated syndrome?

Lebrun-Frenay C, Kantarci OH, Siva A, Pelletier D, Okuda DT 2023 Nov Brain 146 E104-E106

Radiologically isolated syndrome

Lebrun-Frenay C, Kantarci O, Siva A, Azevedo CJ, Makhani N, Pelletier D, Okuda DT 2023 Nov The Lancet Neurology 22 1075-1086

Treatment transitions in neuromyelitis optica spectrum disorder increase risk for disease advancement

Okuda DT, Moog TM, McCreary M, Cook K, Burgess KW, Smith AD 2023 Nov Multiple Sclerosis and Related Disorders 79

Teriflunomide and Time to Clinical Multiple Sclerosis in Patients with Radiologically Isolated Syndrome: The TERIS Randomized Clinical Trial

Lebrun-Frénay C, Siva A, Sormani MP, Landes-Chateau C, Mondot L, Bovis F, Vermersch P, Papeix C, Thouvenot E, Labauge P, Durand-Dubief F, Efendi H, Le Page E, Terzi M, Derache N, Bourre B, Hoepner R, Karabudak R, De Seze J, Ciron J, Clavelou P, Wiertlewski S, Turan OF, Yucear N, Cohen M, Azevedo C, Kantarci OH, Okuda DT, Pelletier D 2023 Oct JAMA neurology 80 1080-1088

Real-World Safety and Effectiveness After 5 Years of Dimethyl Fumarate Treatment in Black and Hispanic Patients with Multiple Sclerosis in ESTEEM

Williams MJ, Amezcua L, Chinea A, Cohan S, Okai A, Okuda DT, Vargas W, Belviso N, Božin I, Jiang X, Lewin JB, Lyons J, Shen C, England SM, Grimes N 2023 Oct Neurology and Therapy 12 1669-1682

MRI to differentiate multiple sclerosis, neuromyelitis optica, and myelin oligodendrocyte glycoprotein antibody disease

Carnero Contentti E, Okuda DT, Rojas JI, Chien C, Paul F, Alonso R 2023 Sep Journal of Neuroimaging 33 688-702

The radiologically isolated syndrome: revised diagnostic criteria

Author Collaboration TR, Lebrun-Frénay C, Okuda DT, Siva A, Landes-Chateau C, Azevedo CJ, Mondot L, Carra-Dallière C, Zephir H, Louapre C, Durand-Dubief F, Le Page E, Bensa C, Ruet A, Ciron J, Laplaud DA, Casez O, Mathey G, De Seze J, Zeydan B, Makhani N, Tutuncu M, Levraut M, Cohen M, Thouvenot E, Pelletier D, Kantarci OH 2023 Aug Brain 146 3431-3443

Impact of COVID-19 vaccination or infection on disease activity in a radiologically isolated syndrome cohort: The VaxiRIS study

Cohen M, Thomel-Rocchi O, Siva A, Okuda DT, Karabudak R, Efendi H, Terzi M, Carra-Dalliere C, Durand-Dubief F, Thouvenot E, Ciron J, Zephir H, Bourre B, Casez O, De Seze J, Moreau T, Neau JP, Pelletier D, Kantarci O, Tutuncu M, Derache N, Bensa C, Louapre C, Benoit J, Landes-Chateau C, Lebrun-Frenay C 2023 Aug Multiple Sclerosis Journal 29 1099-1106

High-efficacy therapies reduce clinical and radiological events more effectively than traditional treatments in neuromyelitis optica spectrum disorder

Moog TM, Smith AD, Burgess KW, McCreary M, Okuda DT 2023 Jul Journal of neurology 270 3595-3602

Presymptomatic MS or radiologically isolated syndrome should be actively monitored and treated: Yes

Lebrun-Frenay C, Okuda DT 2023 Jun Multiple Sclerosis Journal 29 793-795

Selective vulnerability of brainstem and cervical spinal cord regions in people with non-progressive multiple sclerosis of Black or African American and European ancestry

Okuda DT, Stanley T, McCreary M, Smith A, Wilson A, Pinho MC, Yu FF, Billiet T, Van Hecke W, Ribbens A, Zeydan B, Kantarci O, Guo X, Moog TM 2023 May Multiple Sclerosis Journal 29 691-701

Dimethyl Fumarate Delays Multiple Sclerosis in Radiologically Isolated Syndrome

Okuda DT, Kantarci O, Lebrun-Frénay C, Sormani MP, Azevedo CJ, Bovis F, Hua LH, Amezcua L, Mowry EM, Hotermans C, Mendoza J, Walsh JS, von Hehn C, Vargas WS, Donlon S, Naismith RT, Okai A, Pardo G, Repovic P, Stüve O, Siva A, Pelletier D 2023 Mar Annals of Neurology 93 604-614

Factors associated with the misdiagnosis of neuromyelitis optica spectrum disorder

Smith AD, Moog TM, Burgess KW, McCreary M, Okuda DT 2023 Feb Multiple Sclerosis and Related Disorders 70

Sphingosine-1 Phosphate Receptor Modulators Increase In Vitro Melanoma Cell Line Proliferation at Therapeutic Doses Used in Patients with Multiple Sclerosis

Ruetsch-Chelli C, Okuda DT, Rocher F, Tartare-Deckert S, Deckert M, Lebrun-Frenay C 2023 Feb Neurology and Therapy 12 289-302

Neurofilament Light Chain Levels Are Predictive of Clinical Conversion in Radiologically Isolated Syndrome

Rival M, Thouvenot E, De Terdonck LD, Laurent-Chabalier S, Demattei C, Uygunoglu U, Castelnovo G, Cohen M, Okuda DT, Kantarci OH, Pelletier D, Azevedo C, Marin P, Lehmann S, Siva A, Mura T, Lebrun-Frenay C 2023 Jan Neurology: Neuroimmunology and NeuroInflammation 10

Patients with morphea with neurologic involvement: A cross-sectional study and review from the morphea in adults and children cohort

Abbas LF, Joseph AK, Zhu JL, Okuda D, Jacobe HT 2023 Jan Journal of the American Academy of Dermatology 88 172-174

Do magnetic resonance imaging features differ between persons with multiple sclerosis of various races and ethnicities?

Nathoo N, Zeydan B, Neyal N, Chelf C, Okuda DT, Kantarci OH 2023 Frontiers in Neurology 14

Arbaclofen extended-release tablets for spasticity in multiple sclerosis: open-label extension study

Okuda DT, Kantor D, Jaros M, Devries T, Hunter S 2023 Brain Communications 5

Neuroimaging to monitor worsening of multiple sclerosis: advances supported by the grant for multiple sclerosis innovation

Oh J, Airas L, Harrison D, Järvinen E, Livingston T, Lanker S, Malik RA, Okuda DT, Villoslada P, de Vries HE 2023 Frontiers in Neurology 14

Dorsal medulla surface texture: Differentiating neuromyelitis optica spectrum disorder from multiple sclerosis

Okuda DT, Stanley T, McCreary M, Smith AD, Burgess KW, Wilson A, Guo X, Moog TM 2022 Nov Journal of Neuroimaging 32 1090-1097

From the prodromal stage of multiple sclerosis to disease prevention

Marrie RA, Allegretta M, Barcellos LF, Bebo B, Calabresi PA, Correale J, Davis B, De Jager PL, Gasperi C, Greenbaum C, Helme A, Hemmer B, Kanellis P, Kostich W, Landsman D, Lebrun-Frenay C, Makhani N, Munger KL, Okuda DT, Ontaneda D, Postuma RB, Quandt JA, Roman S, Saidha S, Sormani MP, Strum J, Valentine P, Walton C, Zackowski KM, Zhao Y, Tremlett H 2022 Sep Nature Reviews Neurology 18 559-572

Direction and magnitude of displacement differ between slowly expanding and non-expanding multiple sclerosis lesions as compared to small vessel disease

Moog TM, McCreary M, Wilson A, Stanley T, Yu FF, Pinho M, Guo X, Okuda DT 2022 Aug Journal of neurology 269 4459-4468

Editorial: Understanding the concept of pre-clinical autoimmunity

Olsen NJ, Okuda DT, Holers VM, Karp DR 2022 Jul Frontiers in immunology 13

Hiding in plain sight: The magnitude of unused disease modifying therapies in multiple sclerosis and strategies for reducing the economic burden of care

Okuda DT, Burgess KW, Cook K, McCreary M, Winkler MD, Moog TM 2022 Jul Multiple Sclerosis and Related Disorders 63

Outcome measures assisting treatment optimization in multiple sclerosis

Pardo G, Coates S, Okuda DT 2022 Mar Journal of neurology 269 1282-1297

Arbaclofen extended-release tablets for spasticity in multiple sclerosis: Randomized, controlled clinical trial

Okuda DT, Kantor D, Jaros M, Devries T, Hunter S 2022 Brain Communications 4

Risk Factors and Time to Clinical Symptoms of Multiple Sclerosis Among Patients With Radiologically Isolated Syndrome

Author Collaboration ft, Lebrun-Frénay C, Rollot F, Mondot L, Zephir H, Louapre C, Le Page E, Durand-Dubief F, Labauge P, Bensa C, Thouvenot E, Laplaud D, de Seze J, Ciron J, Bourre B, Cabre P, Casez O, Ruet A, Mathey G, Berger E, Moreau T, Khedr AA, Derache N, Clavelou P, Guennoc AM, Créange A, Neau JP, Tourbah A, Camdessanché JP, Maarouf A, Callier C, Vermersch P, Kantarci O, Siva A, Azevedo C, Makhani N, Cohen M, Pelletier D, Okuda D, Vukusic S 2021 Oct JAMA Network Open 4 E2128271

The multiple sclerosis prodrome is just unspecific symptoms in radiologically isolated syndrome patients – No

Tremlett H, Okuda DT, Lebrun-Frenay C 2021 Oct Multiple Sclerosis Journal 27 1824-1826

Cerebellar volume loss in radiologically isolated syndrome

George IC, El Mendili MM, Inglese M, Azevedo CJ, Kantarci O, Lebrun C, Siva A, Okuda DT, Pelletier D 2021 Jan Multiple Sclerosis Journal 27 130-133

Altered task-induced cerebral blood flow and oxygen metabolism underlies motor impairment in multiple sclerosis

West KL, Sivakolundu DK, Zuppichini MD, Turner MP, Spence JS, Lu H, Okuda DT, Rypma B 2021 Jan Journal of Cerebral Blood Flow and Metabolism 41 182-193

State of the Art and Future Challenges in Multiple Sclerosis Research and Medical Management: An Insight into the 5th International Porto Congress of Multiple Sclerosis

Sá MJ, Soares dos Reis R, Altintas A, Celius EG, Chien C, Comi G, Graus F, Hillert J, Hobart J, Khan G, Kissani N, Langdon D, Leite MI, Okuda DT, Palace J, Papais-Alvarenga RM, Mendes-Pinto I, Shi FD 2020 Dec Neurology and Therapy 9 281-300

Real-World Safety and Effectiveness of Dimethyl Fumarate in Black or African American Patients with Multiple Sclerosis: 3-Year Results from ESTEEM

Williams MJ, Amezcua L, Okai A, Okuda DT, Cohan S, Su R, Parks B, Mendoza JP, Lewin JB, Jones CC 2020 Dec Neurology and Therapy 9 483-493

Utility of shape evolution and displacement in the classification of chronic multiple sclerosis lesions

Okuda DT, Moog TM, McCreary M, Bachand JN, Wilson A, Wright K, Winkler MD, Ramos OG, Blinn AP, Wang Y, Stanley T, Pinho MC, Newton BD, Guo X 2020 Dec Scientific reports 10

BOLD signal within and around white matter lesions distinguishes multiple sclerosis and non-specific white matter disease: a three-dimensional approach

Sivakolundu DK, West KL, Zuppichini MD, Wilson A, Moog TM, Blinn AP, Newton BD, Wang Y, Stanley T, Guo X, Rypma B, Okuda DT 2020 Oct Journal of neurology 267 2888-2896

Reduced arterial compliance along the cerebrovascular tree predicts cognitive slowing in multiple sclerosis: Evidence for a neurovascular uncoupling hypothesis

Sivakolundu DK, West KL, Maruthy GB, Zuppichini M, Turner MP, Abdelkarim D, Zhao Y, Nguyen D, Spence JS, Lu H, Okuda DT, Rypma B 2020 Oct Multiple Sclerosis Journal 26 1486-1496

African Americans experience disproportionate neurodegenerative changes in the medulla and upper cervical spinal cord in early multiple sclerosis

Moog TM, McCreary M, Stanley T, Wilson A, Santoyo J, Wright K, Winkler MD, Wang Y, Yu F, Newton BD, Zeydan B, Kantarci O, Guo X, Okuda DT 2020 Oct Multiple Sclerosis and Related Disorders 45

Radiologically Isolated Syndrome: 10-Year Risk Estimate of a Clinical Event

Lebrun-Frenay C, Kantarci O, Siva A, Sormani MP, Pelletier D, Okuda DT, Azevedo C, Amato MP, Bensa C, Berger E, Brochet B, Ciron J, Cohen M, Inglese M, Keegan BM, Labauge P, Laplaud DA, Le Page E, Louapre C, Makhani N, Mathey G, Mondot L, Montalban X, Pelletier J, de Seze J, deStefano N, Thouvenot E, Tintore M, Tutuncuoglu M, Uygunoglu U, Vermersch P, Weinshenker B, Zeydan B 2020 Aug Annals of Neurology 88 407-417

The neurovascular basis of processing speed differences in humans: A model-systems approach using multiple sclerosis

Sivakolundu DK, West KL, Zuppichini M, Turner MP, Abdelkarim D, Zhao Y, Spence JS, Lu H, Okuda DT, Rypma B 2020 Jul NeuroImage 215

Limitations of cell-lineage-specific non-dynamic gene recombination in CD11c.Cre+ITGA4fl/fl mice

Manouchehri N, Hussain RZ, Cravens PD, Doelger R, Greenberg BM, Okuda DT, Forsthuber TG, Eagar TN, Stüve O 2020 Jul Journal of Neuroimmunology 344

Handedness and potential implications for neurorehabilitation in multiple sclerosis

Shirani A, Okuda DT 2020 Jan Multiple Sclerosis and Related Disorders 37

Neuroimaging Insights Into Early Stages of HIV-Progressive Multifocal Leukoencephalopathy: A Case Report

Gonzalez Caldito N, Loeb JS, Okuda DT 2020 Journal of Central Nervous System Disease 12

Atypical Neuromyelitis Optica Spectrum Disorder With Diffuse Cerebral Abnormalities: A Case Report

Newton BD, Kantarci O, Okuda DT 2020 Journal of Central Nervous System Disease 12

Baseline cerebral metabolism predicts fatigue and cognition in Multiple Sclerosis patients

West K, Sivakolundu D, Maruthy G, Zuppichini M, Liu P, Thomas B, Spence J, Lu H, Okuda D, Rypma B 2020 NeuroImage: Clinical 27

Three-Dimensional Lesion Phenotyping and Physiologic Characterization Inform Remyelination Ability in Multiple Sclerosis

Sivakolundu DK, Hansen MR, West KL, Wang Y, Stanley T, Wilson A, McCreary M, Turner MP, Pinho MC, Newton BD, Guo X, Rypma B, Okuda DT 2019 Sep Journal of Neuroimaging 29 605-614

α4-integrin deficiency in B cells does not affect disease in a T-cell-mediated EAE disease model

Hussain RZ, Cravens PD, Miller-Little WA, Doelger R, Granados V, Herndon E, Okuda DT, Eagar TN, Stüve O 2019 Jul Neurology: Neuroimmunology and NeuroInflammation 6

Preserved canonicality of the BOLD hemodynamic response reflects healthy cognition: Insights into the healthy brain through the window of Multiple Sclerosis

Turner MP, Hubbard NA, Sivakolundu DK, Himes LM, Hutchison JL, Hart J, Spence JS, Frohman E, Frohman TC, Okuda D, Rypma B 2019 Apr NeuroImage 190 46-55

Cerebrospinal fluid chitinase-3-like protein 1 level is not an independent predictive factor for the risk of clinical conversion in radiologically isolated syndrome

Thouvenot E, Hinsinger G, Demattei C, Uygunoglu U, Castelnovo G, Pittion-Vouyovitch S, Okuda D, Kantarci O, Pelletier D, Lehmann S, Marin P, Siva A, Lebrun C 2019 Apr Multiple Sclerosis Journal 25 669-677

Leveraging technology to identify subclinical deficits in radiologically isolated syndrome

Okuda D 2019 Jan European Journal of Neurology 26 3-4

Oligoclonal bands increase the specificity of MRI criteria to predict multiple sclerosis in children with radiologically isolated syndrome

Author Collaboration OF, Author Collaboration RI, Author Collaboration PR, Makhani N, Lebrun C, Siva A, Narula S, Wassmer E, Brassat D, Brenton JN, Cabre P, Dallière CC, Seze JD, Dubief FD, Inglese M, Langille M, Mathey G, Neuteboom RF, Pelletier J, Pohl D, Reich DS, Rojas JI, Shabanova V, Shapiro ED, Stone RT, Tenembaum S, Tintoré M, Uygunoglu U, Vargas W, Venkateswaren S, Vermersch P, Kantarci O, Okuda DT, Pelletier D 2019 Multiple Sclerosis Journal - Experimental, Translational and Clinical 5

Body mass index, but not Vitamin D status, is associated with brain volume change in MS

Mowry EM, Azevedo CJ, McCulloch CE, Okuda D, Lincoln RR, Waubant E, Hauser SL, Pelletier D 2018 Dec Neurology 91 E2256-E2264

TLR3 agonism re-establishes CNS immune competence during α4-integrin deficiency

Hussain RZ, Cravens PC, Doelger R, Dentel B, Herndon E, Loof N, Tsai P, Okuda D, Racke MK, Stuve O 2018 Dec Annals of Clinical and Translational Neurology 5 1543-1561

Post-gadolinium 3-dimensional spatial, surface, and structural characteristics of glioblastomas differentiate pseudoprogression from true tumor progression

Hansen MR, Pan E, Wilson A, McCreary M, Wang Y, Stanley T, Pinho MC, Guo X, Okuda DT 2018 Sep Journal of Neuro-Oncology 139 731-738

Precision medicine for multiple sclerosis promotes preventative medicine

Hansen MR, Okuda DT 2018 May Annals of the New York Academy of Sciences 1420 62-71

Classification of multiple sclerosis and non-specific white matter lesions using spherical harmonics descriptors

Wang Y, Hansen M, Okuda D, Wilson A, Guo X 2018 Apr 97-102

Cervical spinal cord atrophy: An earlymarker of progressiveMSonset

Zeydan B, Gu X, Atkinson EJ, Keegan BM, Weinshenker BG, Tillema JM, Pelletier D, Azevedo CJ, Lebrun-Frenay C, Siva A, Okuda DT, Kantarci K, Kantarci OH 2018 Mar Neurology: Neuroimmunology and NeuroInflammation 5

Multiple Sclerosis in the Contemporary Age: Understanding the Millennial Patient with Multiple Sclerosis to Create Next-Generation Care

Hansen MR, Okuda DT 2018 Feb Neurologic Clinics 36 219-230

Contemporary Topics in Multiple Sclerosis

Okuda DT 2018 Feb Neurologic Clinics 36 xiii-xiv

Anomalies Characteristic of Central Nervous System Demyelination: Radiologically Isolated Syndrome

Author Collaboration R, Lebrun C, Kantarci OH, Siva A, Pelletier D, Okuda DT 2018 Feb Neurologic Clinics 36 59-68

Multiple Sclerosis

Okuda DT 2018 Feb Neurologic Clinics 36 i

Radiologically isolated syndrome should be treated with disease-modifying therapy – Yes

Okuda DT 2017 Dec Multiple Sclerosis 23 1818-1819

Three-Dimensional Shape and Surface Features Distinguish Multiple Sclerosis Lesions from Nonspecific White Matter Disease

Newton BD, Wright K, Winkler MD, Bovis F, Takahashi M, Dimitrov IE, Sormani MP, Pinho MC, Okuda DT 2017 Nov Journal of Neuroimaging 27 613-619

Calibrated imaging reveals altered grey matter metabolism related to white matter microstructure and symptom severity in multiple sclerosis

Hubbard NA, Turner MP, Ouyang M, Himes L, Thomas BP, Hutchison JL, Faghihahmadabadi S, Davis SL, Strain JF, Spence J, Krawczyk D, Huang H, Lu H, Hart J, Frohman TC, Frohman E, Okuda D, Rypma B 2017 Nov Human Brain Mapping 38 5375-5390

Patient outcomes influenced by reduced lymphocyte counts after dimethyl fumarate initiation

Wright K, Winkler MD, Newton BD, Sormani MP, Okuda DT 2017 Oct Neurology: Neuroimmunology and NeuroInflammation 4

Radiologically isolated syndrome in children

Makhani N, Lebrun C, Siva A, Brassat D, Carra Dallière C, De Seze J, Du W, Durand Dubief F, Kantarci O, Langille M, Narula S, Pelletier J, Rojas JI, Shapiro ED, Stone RT, Tintoré M, Uygunoglu U, Vermersch P, Wassmer E, Okuda DT, Pelletier D 2017 Oct Neurology: Neuroimmunology and NeuroInflammation 4

Evaluation of visual-evoked cerebral metabolic rate of oxygen as a diagnostic marker in multiple sclerosis

Hubbard NA, Araujo YS, Caballero C, Ouyang M, Turner MP, Himes L, Faghihahmadabadi S, Thomas BP, Hart J, Huang H, Okuda D, Rypma B 2017 Jun Brain Sciences 7

Radiologically Isolated Syndrome: MR Imaging Features Suggestive of Multiple Sclerosis Prior to First Symptom Onset

Okuda DT 2017 May Neuroimaging Clinics of North America 27 267-275

Finger tapping impairments are highly sensitive for evaluating upper motor neuron lesions

Shirani A, Newton BD, Okuda DT 2017 Mar BMC Neurology 17

Are miRNAs appropriate biomarkers for radiologic measures of tissue injury in multiple sclerosis?

Okuda DT 2017 Mar JAMA neurology 74 260-261

Long-term evolution of multiple sclerosis disability in the treatment era

Author Collaboration Uo, Cree BA, Gourraud PA, Oksenberg JR, Bevan C, Crabtree-Hartman E, Gelfand JM, Goodin DS, Graves J, Green AJ, Mowry E, Okuda DT, Pelletier D, von Büdingen HC, Zamvil SS, Agrawal A, Caillier S, Ciocca C, Gomez R, Kanner R, Lincoln R, Lizee A, Qualley P, Santaniello A, Suleiman L, Bucci M, Panara V, Papinutto N, Stern WA, Zhu AH, Cutter GR, Baranzini S, Henry RG, Hauser SL 2016 Oct Annals of Neurology 80 499-510

Long-term evolution of multiple sclerosis disability in the treatment era

Author Collaboration Uo, Cree BA, Gourraud PA, Oksenberg JR, Bevan C, Crabtree-Hartman E, Gelfand JM, Goodin DS, Graves J, Green AJ, Mowry E, Okuda DT, Pelletier D, von Büdingen HC, Zamvil SS, Agrawal A, Caillier S, Ciocca C, Gomez R, Kanner R, Lincoln R, Lizee A, Qualley P, Santaniello A, Suleiman L, Bucci M, Panara V, Papinutto N, Stern WA, Zhu AH, Cutter GR, Baranzini S, Henry RG, Hauser SL 2016 Oct Annals of Neurology 80 499-510

Interleukin 17 alone is not a discriminant biomarker in early demyelinating spectrum disorders

Lebrun C, Cohen M, Pignolet B, Seitz-Polski B, Bucciarelli F, Benzaken S, Kantarci O, Siva A, Okuda D, Pelletier D, Brassat D 2016 Sep Journal of the Neurological Sciences 368 334-336

Incidental Lesions Suggesting Multiple Sclerosis

Okuda DT 2016 Jun CONTINUUM Lifelong Learning in Neurology 22 730-743

Primary Progressive Multiple Sclerosis Evolving from Radiologically Isolated Syndrome

Kantarci OH, Lebrun C, Siva A, Keegan MB, Azevedo CJ, Inglese M, Tintoré M, Newton BD, Durand-Dubief F, Amato MP, De Stefano N, Sormani MP, Pelletier D, Okuda DT 2016 Feb Annals of Neurology 79 288-294

Extended interval dosing of natalizumab in multiple sclerosis

Zhovtis Ryerson L, Frohman TC, Foley J, Kister I, Weinstock-Guttman B, Tornatore C, Pandey K, Donnelly S, Pawate S, Bomprezzi R, Smith D, Kolb C, Qureshi S, Okuda D, Kalina J, Rimler Z, Green R, Monson NL, Hoyt T, Bradshaw M, Fallon J, Chamot E, Bucello M, Beh SC, Cutter G, Major E, Herbert J, Frohman E 2016 Jan Journal of Neurology, Neurosurgery and psychiatry 87 885-889

Therapeutic Advances and Future Prospects in Progressive Forms of Multiple Sclerosis

Shirani A, Okuda DT, Stüve O 2016 Jan Neurotherapeutics 13 58-69

Aquatic training in MS: Neurotherapeutic impact upon quality of life

Frohman AN, Okuda D, Beh SC, Treadaway K, Mooi C, Davis SL, Shah A, Frohman TC, Frohman E 2015 Aug Annals of Clinical and Translational Neurology 2 864-872

Thoracic spinal cord lesions are influenced by the degree of cervical spine involvement in multiple sclerosis

Hua LH, Donlon SL, Sobhanian MJ, Portner SM, Okuda DT 2015 Jul Spinal Cord 53 520-525

Early CNS neurodegeneration in radiologically isolated syndrome

Azevedo CJ, Overton E, Khadka S, Buckley J, Liu S, Sampat M, Kantarci O, Frenay CL, Siva A, Okuda DT, Pelletier D 2015 Jun Neurology: Neuroimmunology and NeuroInflammation 2 e102

Pontine myelinolysis following excessive consumption of commercial energy drinks

Newton BD, Okuda DT 2015 Jun Neurology: Neuroimmunology and NeuroInflammation 2 e91

Central neuropathic pain in MS is due to distinct thoracic spinal cord lesions

Okuda DT, Melmed K, Matsuwaki T, Blomqvist A, Craig AD 2014 Aug Annals of Clinical and Translational Neurology 1 554-561

In vivo evidence of glutamate toxicity in multiple sclerosis

Azevedo CJ, Kornak J, Chu P, Sampat M, Okuda DT, Cree BA, Nelson SJ, Hauser SL, Pelletier D 2014 Aug Annals of Neurology 76 269-278

Radiologically isolated syndrome: 5-year risk for an initial clinical event

Okuda DT, Siva A, Kantarci O, Inglese M, Katz I, Tutuncu M, Keegan BM, Donlon S, Hua LH, Vidal-Jordana A, Montalban X, Rovira A, Tintoré M, Amato MP, Brochet B, De Seze J, Brassat D, Vermersch P, De Stefano N, Sormani MP, Pelletier D, Lebrun C 2014 Mar PloS one 9

A case of Susac syndrome with cervical spinal cord involvement on MRI

Hua LH, Donlon SL, Okuda DT 2014 Feb Journal of the Neurological Sciences 337 228-231

Immunosuppressive treatments in multiple sclerosis

Okuda DT 2014 Handbook of Clinical Neurology 122 503-511

Metabolite changes in radiologically isolated syndrome: More pathology than meets the eye?

Okuda DT, Vrenken H 2013 Jun Neurology 80 2084-2085

Impact of pregnancy on conversion to clinically isolated syndrome in a radiologically isolated syndrome cohort

Lebrun C, Le Page E, Kantarci O, Siva A, Pelletier D, Okuda DT 2012 Sep Multiple Sclerosis Journal 18 1297-1302

Vitamin D status predicts new brain magnetic resonance imaging activity in multiple sclerosis

Mowry EM, Waubant E, McCulloch CE, Okuda DT, Evangelista AA, Lincoln RR, Gourraud PA, Brenneman D, Owen MC, Qualley P, Bucci M, Hauser SL, Pelletier D 2012 Aug Annals of Neurology 72 234-240

From injection therapies to natalizumab: Views on the treatment of multiple sclerosis

Bomprezzi R, Okuda D, Alderazi YJ, Stüve O, Frohman E 2012 Mar Therapeutic Advances in Neurological Disorders 5 97-104

Asymptomatic spinal cord lesions predict disease progression in radiologically isolated syndrome

Okuda DT, Mowry EM, Cree BA, Crabtree EC, Goodin DS, Waubant E, Pelletier D 2011 Feb Neurology 76 686-692

Switching multiple sclerosis patients with breakthrough disease to second-line therapy

Castillo-Trivino T, Mowry EM, Gajofatto A, Chabas D, Crabtree-Hartman E, Cree BA, Goodin DS, Green AJ, Okuda DT, Pelletier D, Zamvil SS, Vittinghoff E, Waubant E 2011 PloS one 6

Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis

Baranzini SE, Srinivasan R, Khankhanian P, Okuda DT, Nelson SJ, Matthews PM, Hauser SL, Oksenberg JR, Pelletier D 2010 Sep Brain 133 2603-2611

High-resolution phased-array MRI of the human brain at 7 tesla: Initial experience in multiple sclerosis patients

Metcalf M, Xu D, Okuda DT, Carvajal L, Srinivasan R, Kelley DA, Mukherjee P, Nelson SJ, Vigneron DB, Pelletier D 2010 Apr Journal of Neuroimaging 20 141-147

Reply from the authors

Okuda DT 2009 Nov Neurology 73 1714

Recurrent asymptomatic demyelinating disease following 13-cis-retinoic acid exposure

Okuda DT, Prados MD 2009 Sep BMJ Case Reports

Difference in disease burden and activity in pediatric patients on brain magnetic resonance imaging at time of multiple sclerosis onset vs adults

Waubant E, Chabas D, Okuda DT, Glenn O, Mowry E, Henry RG, Strober JB, Soares B, Wintermark M, Pelletier D 2009 Aug Archives of neurology 66 967-971

Connecting white matter injury and thalamic atrophy in clinically isolated syndromes

Henry RG, Shieh M, Amirbekian B, Chung S, Okuda DT, Pelletier D 2009 Jul Journal of the Neurological Sciences 282 61-66

Quality of life in multiple sclerosis is associated with lesion burden and brain volume measures

Mowry EM, Beheshtian A, Waubant E, Goodin DS, Cree BA, Qualley P, Lincoln R, George MF, Gomez R, Hauser SL, Okuda DT, Pelletier D 2009 May Neurology 72 1760-1765

Erratum: Incidental MRI anomalies suggestive of multiple sclerosis: The radiologically isolated syndrome (Neurology® (2009) 72 (800-805))

Okuda DT 2009 Apr Neurology 72 1284

Incidental MRI anomalies suggestive of multiple sclerosis: The radiologically isolated syndrome

Okuda DT, Mowry EM, Beheshtian A, Waubant E, Baranzini SE, Goodin DS, Hauser SL, Pelletier D 2009 Mar Neurology 72 800-805

Genotype-phenotype correlations in multiple sclerosis: HLA genes influence disease severity inferred by 1HMR spectroscopy and MRI measures

Okuda DT, Srinivasan R, Oksenberg JR, Goodin DS, Baranzini SE, Beheshtian A, Waubant E, Zamvil SS, Leppert D, Qualley P, Lincoln R, Gomez R, Caillier S, George M, Wang J, Nelson SJ, Cree BA, Hauser SL, Pelletier D 2009 Jan Brain 132 250-259

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis

Baranzini SE, Wang J, Gibson RA, Galwey N, Naegelin Y, Barkhof F, Radue EW, Lindberg RL, Uitdehaag BM, Johnson MR, Angelakopoulou A, Hall L, Richardson JC, Prinjha RK, Gass A, Geurts JJ, Kragt J, Sombekke M, Vrenken H, Qualley P, Lincoln RR, Gomez R, Caillier SJ, George MF, Mousavi H, Guerrero R, Okuda DT, Cree BA, Green AJ, Waubant E, Goodin DS, Pelletier D, Matthews PM, Hauser SL, Kappos L, Polman CH, Oksenberg JR 2009 Human molecular genetics 18 767-778

Unanticipated demyelinating pathology of the CNS

Okuda DT 2009 Nature Reviews Neurology 5 591-597

Quantitative in vivo magnetic resonance imaging of multiple sclerosis at 7 Tesla with sensitivity to iron

Hammond KE, Metcalf M, Carvajal L, Okuda DT, Srinivasan R, Vigneron D, Nelson SJ, Pelletier D 2008 Dec Annals of Neurology 64 707-713

Looking beyond head trauma

Okuda DT 2008 Nov Science 322 1186

Regional grey matter atrophy in clinically isolated syndromes at presentation

Henry RG, Shieh M, Okuda DT, Evangelista A, Gorno-Tempini ML, Pelletier D 2008 Nov Journal of Neurology, Neurosurgery and psychiatry 79 1236-1244

Abrogation of T cell quiescence characterizes patients at high risk for multiple sclerosis after the initial neurological event

Corvol JC, Pelletier D, Henry RG, Caillier SJ, Wang J, Pappas D, Casazza S, Okuda DT, Hauser SL, Oksenberg JR, Baranzini SE 2008 Aug Proceedings of the National Academy of Sciences of the United States of America 105 11839-11844

Focal lesion in the splenium of the corpus callosum

Okuda DT 2008 Jun Archives of neurology 65

Ethical perspectives in neurology

Okuda DT 2007 Oct CONTINUUM Lifelong Learning in Neurology 13 198-201

Acute pathological laughter

Okuda DT, Chyung AS, Chin CT, Waubant E 2005 Oct Movement Disorders 20 1389-1390

Hypergraphia in the age of computers

Okuda DT, Chung SS 2004 Jun Neurology 62 2329-2330

Naegleria fowleri hemorrhagic meningoencephalitis: Report of two fatalities in children

Okuda DT, Hanna HJ, Coons SW, Bodensteiner JB 2004 Mar Journal of child neurology 19 231-233

Naegleria fowleri meningoencephalitis

Okuda DT, Coons S 2003 Jul Neurology 61 E1

Arterial thrombosis induced by IVIg and its treatment with tPA

Okuda D, Flaster M, Frey J, Sivakumar K 2003 Jun Neurology 60 1825-1826