Featured Publications
Interaction between the gut microbiota and colonic enteroendocrine cells regulates host metabolism.
Tan S, Santolaya JL, Wright TF, Liu Q, Fujikawa T, Chi S, Bergstrom CP, Lopez A, Chen Q, Vale G, McDonald JG, Schmidt A, Vo N, Kim J, Baniasadi H, Li L, Zhu G, He TC, Zhan X, Obata Y, Jin A, Jia D, Elmquist JK, Sifuentes-Dominguez L, Burstein E, 2024 May Nat MetabMacrophages regulate gastrointestinal motility through complement component 1q.
Pendse M, De Selle H, Vo N, Quinn G, Dende C, Li Y, Salinas CN, Srinivasan T, Propheter DC, Crofts AA, Koo E, Hassell B, Ruhn KA, Raj P, Obata Y, Hooper LV, 2023 Apr Elife 12
Ehichioya DE, Taufique SKT, Magaña I, Farah S, Obata Y, Yamazaki S,
2023
Front Physiol
14
1299474
Molecular profiling of enteric nervous system cell lineages.
Obata Y, Castaño Á, Fallesen TL, Bon-Frauches AC, Boeing S, Huseynova A, McCallum S, Lasrado R, Heanue TA, Pachnis V, 2022 Jun Nat ProtocNeuronal programming by microbiota regulates intestinal physiology.
Obata Y, Castaño Á, Boeing S, Bon-Frauches AC, Fung C, Fallesen T, de Agüero MG, Yilmaz B, Lopes R, Huseynova A, Horswell S, Maradana MR, Boesmans W, Vanden Berghe P, Murray AJ, Stockinger B, Macpherson AJ, Pachnis V, 2020 02 Nature 7794 578 284-289
Obata Y, Pachnis V,
2016 11
Gastroenterology
5
151
836-844
Obata Y, Furusawa Y, Endo TA, Sharif J, Takahashi D, Atarashi K, Nakayama M, Onawa S, Fujimura Y, Takahashi M, Ikawa T, Otsubo T, Kawamura YI, Dohi T, Tajima S, Masumoto H, Ohara O, Honda K, Hori S, Ohno H, Koseki H, Hase K,
2014 Jun
Nat Immunol
6
15
571-9
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells.
Furusawa Y, Obata Y, Fukuda S, Endo TA, Nakato G, Takahashi D, Nakanishi Y, Uetake C, Kato K, Kato T, Takahashi M, Fukuda NN, Murakami S, Miyauchi E, Hino S, Atarashi K, Onawa S, Fujimura Y, Lockett T, Clarke JM, Topping DL, Tomita M, Hori S, Ohara O, Morita T, Koseki H, Kikuchi J, Honda K, Hase K, Ohno H, 2013 Dec Nature 7480 504 446-50
Nakamura A, Kurihara S, Takahashi D, Ohashi W, Nakamura Y, Kimura S, Onuki M, Kume A, Sasazawa Y, Furusawa Y, Obata Y, Fukuda S, Saiki S, Matsumoto M, Hase K,
2021 04
Nat Commun
1
12
2105
Enteric glia as a source of neural progenitors in adult zebrafish.
McCallum S, Obata Y, Fourli E, Boeing S, Peddie CJ, Xu Q, Horswell S, Kelsh RN, Collinson L, Wilkinson D, Pin C, Pachnis V, Heanue TA, 2020 08 Elife 9
Obata Y, Pachnis V,
2020 08
Proc Natl Acad Sci U S A
33
117
19624-19626
Commensal-bacteria-derived butyrate promotes the T-cell-independent IgA response in the colon.
Isobe J, Maeda S, Obata Y, Iizuka K, Nakamura Y, Fujimura Y, Kimizuka T, Hattori K, Kim YG, Morita T, Kimura I, Offermanns S, Adachi T, Nakao A, Kiyono H, Takahashi D, Hase K, 2020 04 Int Immunol 4 32 243-258
Kimura S, Kobayashi N, Nakamura Y, Kanaya T, Takahashi D, Fujiki R, Mutoh M, Obata Y, Iwanaga T, Nakagawa T, Kato N, Sato S, Kaisho T, Ohno H, Hase K,
2019 04
J Exp Med
4
216
831-846
NALT M cells are important for immune induction for the common mucosal immune system.
Date Y, Ebisawa M, Fukuda S, Shima H, Obata Y, Takahashi D, Kato T, Hanazato M, Nakato G, Williams IR, Hase K, Ohno H, 2017 12 Int Immunol 10 29 471-478Fine-tuning of the mucosal barrier and metabolic systems using the diet-microbial metabolite axis.
Nagai M, Obata Y, Takahashi D, Hase K, 2016 Aug Int Immunopharmacol 37 79-86
Nakato G, Hase K, Sato T, Kimura S, Sakakibara S, Sugiyama M, Obata Y, Hanazato M, Iwanaga T, Ohno H,
2016
PLoS One
3
11
e0150379
Kimura S, Yamakami-Kimura M, Obata Y, Hase K, Kitamura H, Ohno H, Iwanaga T,
2015 May
Mucosal Immunol
3
8
650-60
Epigenetic modifications of the immune system in health and disease.
Obata Y, Furusawa Y, Hase K, 2015 Mar Immunol Cell Biol 3 93 226-32Unique lamina propria stromal cells imprint the functional phenotype of mucosal dendritic cells.
Vicente-Suarez I, Larange A, Reardon C, Matho M, Feau S, Chodaczek G, Park Y, Obata Y, Gold R, Wang-Zhu Y, Lena C, Zajonc DM, Schoenberger SP, Kronenberg M, Cheroutre H, 2015 Jan Mucosal Immunol 1 8 141-51Commensal microbiota regulates T cell fate decision in the gut.
Furusawa Y, Obata Y, Hase K, 2015 Jan Semin Immunopathol 1 37 17-25MUCOSAL IMMUNOLOGY. The microbiota regulates type 2 immunity through ROR?t? T cells.
Ohnmacht C, Park JH, Cording S, Wing JB, Atarashi K, Obata Y, Gaboriau-Routhiau V, Marques R, Dulauroy S, Fedoseeva M, Busslinger M, Cerf-Bensussan N, Boneca IG, Voehringer D, Hase K, Honda K, Sakaguchi S, Eberl G, 2015 Aug Science 6251 349 989-93
Obata Y, Kimura S, Nakato G, Iizuka K, Miyagawa Y, Nakamura Y, Furusawa Y, Sugiyama M, Suzuki K, Ebisawa M, Fujimura Y, Yoshida H, Iwanaga T, Hase K, Ohno H,
2014 Dec
EMBO Rep
12
15
1297-304
Furusawa Y, Endo TA, Obata Y, Ohara O, Ohno H, Hase K,
2014 Dec
Genom Data
2
176-80
Hase K, Nakatsu F, Ohmae M, Sugihara K, Shioda N, Takahashi D, Obata Y, Furusawa Y, Fujimura Y, Yamashita T, Fukuda S, Okamoto H, Asano M, Yonemura S, Ohno H,
2013 Sep
Gastroenterology
3
145
625-35
Distinct Roles for CXCR6(+) and CXCR6(-) CD4(+) T Cells in the Pathogenesis of Chronic Colitis.
Mandai Y, Takahashi D, Hase K, Obata Y, Furusawa Y, Ebisawa M, Nakagawa T, Sato T, Katsuno T, Saito Y, Shimaoka T, Yokosuka O, Yokote K, Ohno H, 2013 PLoS One 6 8 e65488
Obata Y, Takahashi D, Ebisawa M, Kakiguchi K, Yonemura S, Jinnohara T, Kanaya T, Fujimura Y, Ohmae M, Hase K, Ohno H,
2012 Mar
J Immunol
5
188
2427-36
The epithelia-specific membrane trafficking factor AP-1B controls gut immune homeostasis in mice.
Takahashi D, Hase K, Kimura S, Nakatsu F, Ohmae M, Mandai Y, Sato T, Date Y, Ebisawa M, Kato T, Obata Y, Fukuda S, Kawamura YI, Dohi T, Katsuno T, Yokosuka O, Waguri S, Ohno H, 2011 Aug Gastroenterology 2 141 621-32