Publications

Featured Publications

JIB-04 Has Broad-Spectrum Antiviral Activity and Inhibits SARS-CoV-2 Replication and Coronavirus Pathogenesis.

Son J, Huang S, Zeng Q, Bricker TL, Case JB, Zhou J, Zang R, Liu Z, Chang X, Darling TL, Xu J, Harastani HH, Chen L, Gomez Castro MF, Zhao Y, Kohio HP, Hou G, Fan B, Niu B, Guo R, Rothlauf PW, Bailey AL, Wang X, Shi PY, Martinez ED, Brody SL, Whelan SPJ, Diamond MS, Boon ACM, Li B, Ding S, 2022 Jan mBio e0337721

Inhibition of Jumonji demethylases reprograms severe dilated cardiomyopathy and prolongs survival.

Tran TA, Zhang QJ, Wang L, Gonzales C, Girard L, May H, Gillette T, Liu ZP, Martinez ED, 2021 Dec J Biol Chem 101515

Disruption of the Plasmodium falciparum Life Cycle through Transcriptional Reprogramming by Inhibitors of Jumonji Demethylases.

Matthews KA, Senagbe KM, Nötzel C, Gonzales CA, Tong X, Rijo-Ferreira F, Bhanu NV, Miguel-Blanco C, Lafuente-Monasterio MJ, Garcia BA, Kafsack BFC, Martinez ED, 2020 Apr ACS Infect Dis

Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks.

Bayo J, Tran TA, Wang L, Peña-Llopis S, Das AK, Martinez ED 2018 Oct Cell Rep 4 25 1040-1050.e5

Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis.

Zhang QJ, Tran TAT, Wang M, Ranek MJ, Kokkonen-Simon KM, Gao J, Luo X, Tan W, Kyrychenko V, Liao L, Xu J, Hill JA, Olson EN, Kass DA, Martinez ED, Liu ZP, 2018 12 Nat Commun 1 9 5230

Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors.

Dalvi MP, Wang L, Zhong R, Kollipara RK, Park H, Bayo J, Yenerall P, Zhou Y, Timmons BC, Rodriguez-Canales J, Behrens C, Mino B, Villalobos P, Parra ER, Suraokar M, Pataer A, Swisher SG, Kalhor N, Bhanu NV, Garcia BA, Heymach JV, Coombes K, Xie Y, Girard L, Gazdar AF, Kittler R, Wistuba II, Minna JD, Martinez ED 2017 May Cell Rep 8 19 1669-1684

A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth.

Wang L, Chang J, Varghese D, Dellinger M, Kumar S, Best AM, Ruiz J, Bruick R, Peña-Llopis S, Xu J, Babinski DJ, Frantz DE, Brekken RA, Quinn AM, Simeonov A, Easmon J, Martinez ED 2013 Jun Nat Commun 4 2035

Falling off the academic bandwagon. Women are more likely to quit at the postdoc to principal investigator transition.

Martinez ED, Botos J, Dohoney KM, Geiman TM, Kolla SS, Olivera A, Qiu Y, Rayasam GV, Stavreva DA, Cohen-Fix O 2007 Nov EMBO Rep. 11 8 977-81

Epigenetic modulation reveals differentiation state specificity of oncogene addiction.

Khaliq M, Manikkam M, Martinez ED, Fallahi-Sichani M, 2021 03 Nat Commun 1 12 1536

A UHPLC-MS/MS method for the quantification of JIB-04 in rat plasma: Development, validation and application to pharmacokinetics study.

Wang Y, Ma J, Martinez ED, Liang D, Xie H, 2020 Nov J Pharm Biomed Anal 191 113587

Genetic heterogeneity within collective invasion packs drives leader and follower cell phenotypes.

Zoeller EL, Pedro B, Konen J, Dwivedi B, Rupji M, Sundararaman N, Wang L, Horton JR, Zhong C, Barwick BG, Cheng X, Martinez ED, Torres MP, Kowalski J, Marcus AI, Vertino PM, 2019 Sep J. Cell. Sci.

A comprehensive study of epigenetic alterations in hepatocellular carcinoma identifies potential therapeutic targets.

Bayo J, Fiore EJ, Dominguez LM, Real A, Malvicini M, Rizzo M, Atorrasagasti C, García MG, Argemi J, Martinez ED, Mazzolini GD, 2019 Mar J. Hepatol.

Telomerase-Mediated Strategy for Overcoming Non-Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance.

Mender I, LaRanger R, Luitel K, Peyton M, Girard L, Lai TP, Batten K, Cornelius C, Dalvi MP, Ramirez M, Du W, Wu LF, Altschuler SJ, Brekken R, Martinez ED, Minna JD, Wright WE, Shay JW 2018 Aug Neoplasia 8 20 826-837

JumonjiC demethylase inhibitors show potential for targeting chemotherapy-resistant lung cancers.

Dalvi MP, Martinez ED 2017 Mol Cell Oncol 5 4 e1345352

Assessing histone demethylase inhibitors in cells: lessons learned.

Hatch SB, Yapp C, Montenegro RC, Savitsky P, Gamble V, Tumber A, Ruda GF, Bavetsias V, Fedorov O, Atrash B, Raynaud F, Lanigan R, Carmichael L, Tomlin K, Burke R, Westaway SM, Brown JA, Prinjha RK, Martinez ED, Oppermann U, Schofield CJ, Bountra C, Kawamura A, Blagg J, Brennan PE, Rossanese O, Müller S 2017 Epigenetics Chromatin 10 9

Unique epigenetic gene profiles define human breast cancers with poor prognosis.

Peña-Llopis S, Wan Y, Martinez ED 2016 Nov Oncotarget

Inhibiting the Jumonji family: a potential new clinical approach to targeting aberrant epigenetic mechanisms.

Martinez ED, Gazdar AF 2016 Feb Epigenomics

KDM4/JMJD2 Histone Demethylase Inhibitors Block Prostate Tumor Growth by Suppressing the Expression of AR and BMYB-Regulated Genes.

Duan L, Rai G, Roggero C, Zhang QJ, Wei Q, Ma SH, Zhou Y, Santoyo J, Martinez ED, Xiao G, Raj GV, Jadhav A, Simeonov A, Maloney DJ, Rizo J, Hsieh JT, Liu ZP 2015 Sep Chem. Biol. 9 22 1185-96

Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases.

Thinnes CC, Tumber A, Yapp C, Scozzafava G, Yeh T, Chan MC, Tran TA, Hsu K, Tarhonskaya H, Walport LJ, Wilkins SE, Martinez ED, Müller S, Pugh CW, Ratcliffe PJ, Brennan PE, Kawamura A, Schofield CJ 2015 Sep Chem. Commun. (Camb.)

Successful strategies in the discovery of small-molecule epigenetic modulators with anticancer potential.

Bayo J, Dalvi MP, Martinez ED 2015 Oct Future Med Chem

?Klotho is a novel marker and cell survival factor in a subset of triple negative breast cancers.

Trošt N, Peña-Llopis S, Koirala S, Stojan J, Potts PR, Tacer KF, Martinez ED 2015 Nov Oncotarget

Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma.

Chen Y, Terajima M, Yang Y, Sun L, Ahn YH, Pankova D, Puperi DS, Watanabe T, Kim MP, Blackmon SH, Rodriguez J, Liu H, Behrens C, Wistuba II, Minelli R, Scott KL, Sanchez-Adams J, Guilak F, Pati D, Thilaganathan N, Burns AR, Creighton CJ, Martinez ED, Zal T, Grande-Allen KJ, Yamauchi M, Kurie JM 2015 Feb J. Clin. Invest.

A Subset of Nuclear Receptors are Uniquely Expressed in Uveal Melanoma Cells.

Huffman KE, Carstens R, Martinez ED 2015 Front Endocrinol (Lausanne) 6 93

Identification of a novel actin-dependent signal transducing module allows for the targeted degradation of GLI1.

Schneider P, Miguel Bayo-Fina J, Singh R, Kumar Dhanyamraju P, Holz P, Baier A, Fendrich V, Ramaswamy A, Baumeister S, Martinez ED, Lauth M 2015 Nat Commun 6 8023

2-Benzazolyl-4-Piperazin-1-Ylsulfonylbenzenecarbohydroxamic Acids as Novel Selective Histone Deacetylase-6 Inhibitors with Antiproliferative Activity.

Wang L, Kofler M, Brosch G, Melesina J, Sippl W, Martinez ED, Easmon J 2015 PLoS ONE 12 10 e0134556

Identification of Small Molecule Modulators of Gene Transcription with Anticancer Activity.

Tran TA, Wichterman-Kouznetsova J, Varghese D, Huang R, Huang W, Becker M, Austin CP, Inglese J, Johnson RL, Martinez ED 2014 Sep ACS Chem. Biol.

Pre-Clinical Studies of Epigenetic Therapies Targeting Histone Modifiers in Lung Cancer.

Huffman K, Martinez ED 2013 Front Oncol 3 235

Anthraquinones from a marine-derived Streptomyces spinoverrucosus.

Hu Y, Martinez ED, MacMillan JB 2012 Oct J. Nat. Prod. 10 75 1759-64

Differential response of cancer cells to HDAC inhibitors trichostatin A and depsipeptide.

Chang J, Varghese DS, Gillam MC, Peyton M, Modi B, Schiltz RL, Girard L, Martinez ED 2012 Jan Br. J. Cancer 1 106 116-25

Identification of four potential epigenetic modulators from the NCI structural diversity library using a cell-based assay.

Best AM, Chang J, Dull AB, Beutler JA, Martinez ED 2011 J. Biomed. Biotechnol. 2011 868095

Expression profiling of nuclear receptors in the NCI60 cancer cell panel reveals receptor-drug and receptor-gene interactions.

Holbeck S, Chang J, Best AM, Bookout AL, Mangelsdorf DJ, Martinez ED 2010 Jun Mol. Endocrinol. 6 24 1287-96

Characterizing heterogeneous cellular responses to perturbations.

Slack MD, Martinez ED, Wu LF, Altschuler SJ 2008 Dec Proc. Natl. Acad. Sci. U.S.A. 49 105 19306-11

A quantitative high-throughput screen identifies potential epigenetic modulators of gene expression.

Johnson RL, Huang W, Jadhav A, Austin CP, Inglese J, Martinez ED 2008 Apr Anal. Biochem. 2 375 237-48

HDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcription.

Qiu Y, Zhao Y, Becker M, John S, Parekh BS, Huang S, Hendarwanto A, Martinez ED, Chen Y, Lu H, Adkins NL, Stavreva DA, Wiench M, Georgel PT, Schiltz RL, Hager GL 2006 Jun Mol. Cell 5 22 669-79

Fluorescent protein-based cellular assays analyzed by laser-scanning microplate cytometry in 1536-well plate format.

Auld DS, Johnson RL, Zhang YQ, Veith H, Jadhav A, Yasgar A, Simeonov A, Zheng W, Martinez ED, Westwick JK, Austin CP, Inglese J 2006 Meth. Enzymol. 414 566-89

Development of assays for nuclear receptor modulators using fluorescently tagged proteins.

Martinez ED, Hager GL 2006 Meth. Enzymol. 414 37-50

High-content fluorescence-based screening for epigenetic modulators.

Martinez ED, Dull AB, Beutler JA, Hager GL 2006 Meth. Enzymol. 414 21-36

High content screens for epigenetic modulators

Martinez, E.D., Dull, A., McMahon, J., Beutler, J. and Hager, G.L. 2006

An estrogen receptor chimera senses ligands by nuclear translocation.

Martinez ED, Rayasam GV, Dull AB, Walker DA, Hager GL 2005 Dec J. Steroid Biochem. Mol. Biol. 4 97 307-21

Analysis of the hormone-binding domain of steroid receptors using chimeras generated by homologous recombination.

Martinez ED, Pattabiraman N, Danielsen M 2005 Aug Exp. Cell Res. 2 308 320-33

Subnuclear trafficking and gene targeting by steroid receptors.

Nagaich AK, Rayasam GV, Martinez ED, Becker M, Qiu Y, Johnson TA, Elbi C, Fletcher TM, John S, Hager GL 2004 Jun Ann. N. Y. Acad. Sci. 1024 213-20

Methoxyacetic acid disregulation of androgen receptor and androgen-binding protein expression in adult rat testis.

Tirado OM, Martinez ED, Rodriguez OC, Danielsen M, Selva DM, Reventós J, Munell F, Suárez-Quian CA 2003 Apr Biol. Reprod. 4 68 1437-46

Loss of androgen receptor transcriptional activity at the G(1)/S transition.

Martinez ED, Danielsen M 2002 Aug J. Biol. Chem. 33 277 29719-29

Effects of antiandrogens on chromatin remodeling and transcription of the integrated mouse mammary tumor virus promoter.

List HJ, Smith CL, Martinez E, Harris VK, Danielsen M, Riegel AT, 2000 Oct Exp. Cell Res. 1 260 160-5

The Nuclear Receptor Resource: a growing family

Martinez, E., Moore, D., Keller, E., Pearce, D., Vanden Heuvel, J.P., Robinson, V., Gottlieb, B., McDonald, P., Simons, S., Sanchez, E. and Danielsen, M. 1998 26 239-241

The Nuclear Receptor Resource Project.

Martinez E, Moore DD, Keller E, Pearce D, Robinson V, MacDonald PN, Simons SS, Sanchez E, Danielsen M, 1997 Jan Nucleic Acids Res. 1 25 163-5

Catheter-related complications of cancer therapy.

Greene JN, 1996 Jun Infect Dis Clin North Am 2 10 255-95

The glucocorticoid receptor resource.

Danielsen M, Martinez E, 1996 Jan Nucleic Acids Res. 1 24 155-6