Publications

Featured Publications

Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor, LXRα.

Peet, D.J., Turley, S.D., Ma, W., Janowski, B.A., Lobaccaro, J.A., Hammer, R.E., and Mangelsdorf, D.J. May 1998 93 693-704

Characterization of the endogenous DAF-12 ligand and its use as an anthelmintic agent in Strongyloides stercoralis.

Wang Z, Cheong MC, Tsien J, Deng H, Qin T, Stoltzfus JD, Jaleta TG, Li X, Lok JB, Kliewer SA, Mangelsdorf DJ, 2021 12 Elife 10

Pancreatitis is an FGF21-deficient state that is corrected by replacement therapy.

Hernandez G, Luo T, Javed TA, Wen L, Kalwat MA, Vale K, Ammouri F, Husain SZ, Kliewer SA, Mangelsdorf DJ, 2020 Jan Sci Transl Med 525 12

The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol.

Song P, Zechner C, Hernandez G, Cánovas J, Xie Y, Sondhi V, Wagner M, Stadlbauer V, Horvath A, Leber B, Hu MC, Moe OW, Mangelsdorf DJ, Kliewer SA 2018 Apr Cell Metab.

FGF21 Is an Exocrine Pancreas Secretagogue.

Coate KC, Hernandez G, Thorne CA, Sun S, Le TD, Vale K, Kliewer SA, Mangelsdorf DJ 2016 Dec Cell Metab.

The Nuclear Receptor DAF-12 Regulates Nutrient Metabolism and Reproductive Growth in Nematodes.

Wang Z, Stoltzfus J, You YJ, Ranjit N, Tang H, Xie Y, Lok JB, Mangelsdorf DJ, Kliewer SA 2015 Mar PLoS Genet. 3 11 e1005027

Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21.

Owen BM, Mangelsdorf DJ, Kliewer SA 2015 Jan Trends Endocrinol. Metab. 1 26 22-29

FGF21 Regulates Sweet and Alcohol Preference.

Talukdar S, Owen BM, Song P, Hernandez G, Zhang Y, Zhou Y, Scott WT, Paratala B, Turner T, Smith A, Bernardo B, Müller CP, Tang H, Mangelsdorf DJ, Goodwin B, Kliewer SA 2015 Dec Cell Metab.

Nuclear Receptors, RXR, and the Big Bang.

Evans RM, Mangelsdorf DJ 2014 Mar Cell 1 157 255-266

FGF21 regulates metabolism and circadian behavior by acting on the nervous system.

Bookout AL, de Groot MH, Owen BM, Lee S, Gautron L, Lawrence HL, Ding X, Elmquist JK, Takahashi JS, Mangelsdorf DJ, Kliewer SA 2013 Aug Nat. Med.

FGF21 contributes to neuroendocrine control of female reproduction.

Owen BM, Bookout AL, Ding X, Lin VY, Atkin SD, Gautron L, Kliewer SA, Mangelsdorf DJ 2013 Aug Nat. Med.

FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis.

Kir S, Beddow SA, Samuel VT, Miller P, Previs SF, Suino-Powell K, Xu HE, Shulman GI, Kliewer SA, Mangelsdorf DJ 2011 Mar Science 6024 331 1621-4

Endocrine Regulation of the Fasting Response by PPARalpha-mediated Induction of Fibroblast Growth Factor 21.

Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., Elmquist, J.K., Gerard, R.D., Burgess, S.C., Hammer, R.E., Mangelsdorf, D.J., Kliewer, S.A. 2007 5 415-425

Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans.

Motola, D.L., Cummins, C.L., Rottiers, V., Sharma, K.K., Li, T., Li, Y., Suino-Powell, K., Xu, H.E., Auchus, R.J., Antebi, A., Mangelsdorf, D.J. 2006 124 1209-1223

Identification of a nuclear receptor for bile acids.

Makishima, M., Okamoto, A.Y., Repa, J.J., Tu, H., Learned, R.M., Luk, A., Hull, M.V., Lustig, K.D., Mangelsdorf, D.J., and Shan, B. 1999 284 362-365

Identification of an oxysterol signaling pathway mediated by the nuclear receptor, LXR-alpha

Janowski, B.A., Willy, P.J., Rama Devi, T., Falck, J.R., and Mangelsdorf, D.J. 1996 383 728-731

The 'nuclear option' revisited: Confirmation of Ss-daf-12 function and therapeutic potential in Strongyloides stercoralis and other parasitic nematode infections.

Lok JB, Kliewer SA, Mangelsdorf DJ, 2022 Jun Mol Biochem Parasitol 250 111490

The energy balance model of obesity: beyond calories in, calories out.

Hall KD, Farooqi IS, Friedman JM, Klein S, Loos RJF, Mangelsdorf DJ, O'Rahilly S, Ravussin E, Redman LM, Ryan DH, Speakman JR, Tobias DK, 2022 Feb Am J Clin Nutr

FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes.

Abu-Odeh M, Zhang Y, Reilly SM, Ebadat N, Keinan O, Valentine JM, Hafezi-Bakhtiari M, Ashayer H, Mamoun L, Zhou X, Zhang J, Yu RT, Dai Y, Liddle C, Downes M, Evans RM, Kliewer SA, Mangelsdorf DJ, Saltiel AR, 2021 Jun Cell Rep 13 35 109331

Identification of a nuclear receptor/coactivator developmental signaling pathway in the nematode parasite Strongyloides stercoralis.

Cheong MC, Wang Z, Jaleta TG, Li X, Lok JB, Kliewer SA, Mangelsdorf DJ, 2021 Feb Proc Natl Acad Sci U S A 8 118

The Schistosoma mansoni nuclear receptor FTZ-F1 maintains esophageal gland function via transcriptional regulation of meg-8.3.

Romero AA, Cobb SA, Collins JNR, Kliewer SA, Mangelsdorf DJ, Collins JJ, 2021 Dec PLoS Pathog 12 17 e1010140

Dafachronic acid and temperature regulate canonical dauer pathways during Nippostrongylus brasiliensis infectious larvae activation.

Ayoade KO, Carranza FR, Cho WH, Wang Z, Kliewer SA, Mangelsdorf DJ, Stoltzfus JDC, 2020 Apr Parasit Vectors 1 13 162

The orphan nuclear receptor SHP regulates ER stress response by inhibiting XBP1s degradation.

Sun S, Kelekar S, Kliewer SA, Mangelsdorf DJ, 2019 Jul Genes Dev.

A Dozen Years of Discovery: Insights into the Physiology and Pharmacology of FGF21.

Kliewer SA, Mangelsdorf DJ 2019 Feb Cell Metab. 2 29 246-253

PPAR?-K107 SUMOylation regulates insulin sensitivity but not adiposity in mice.

Katafuchi T, Holland WL, Kollipara RK, Kittler R, Mangelsdorf DJ, Kliewer SA 2018 11 Proc. Natl. Acad. Sci. U.S.A. 48 115 12102-12111

FGF19, FGF21, and an FGFR1/?-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia.

Lan T, Morgan DA, Rahmouni K, Sonoda J, Fu X, Burgess SC, Holland WL, Kliewer SA, Mangelsdorf DJ 2017 Oct Cell Metab.

Nuclear receptors: emerging drug targets for parasitic diseases.

Wang Z, Schaffer NE, Kliewer SA, Mangelsdorf DJ 2017 Feb J. Clin. Invest.

Methylprednisolone acetate induces, and ?7-dafachronic acid suppresses, Strongyloides stercoralis hyperinfection in NSG mice.

Patton JB, Bonne-Année S, Deckman J, Hess JA, Torigian A, Nolan TJ, Wang Z, Kliewer SA, Durham AC, Lee JJ, Eberhard ML, Mangelsdorf DJ, Lok JB, Abraham D 2017 Dec Proc. Natl. Acad. Sci. U.S.A.

Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution.

Youm YH, Horvath TL, Mangelsdorf DJ, Kliewer SA, Dixit VD 2016 Jan Proc. Natl. Acad. Sci. U.S.A. 4 113 1026-31

Regulation of Life Cycle Checkpoints and Developmental Activation of Infective Larvae in Strongyloides stercoralis by Dafachronic Acid.

Albarqi MM, Stoltzfus JD, Pilgrim AA, Nolan TJ, Wang Z, Kliewer SA, Mangelsdorf DJ, Lok JB 2016 Jan PLoS Pathog. 1 12 e1005358

KLB is associated with alcohol drinking, and its gene product ?-Klotho is necessary for FGF21 regulation of alcohol preference.

Schumann G, Liu C, O'Reilly P, Gao H, Song P, Xu B, Ruggeri B, Amin N, Jia T, Preis S, Segura Lepe M, Akira S, Barbieri C, Baumeister S, Cauchi S, Clarke TK, Enroth S, Fischer K, Hällfors J, Harris SE, Hieber S, Hofer E, Hottenga JJ, Johansson Å, Joshi PK, Kaartinen N, Laitinen J, Lemaitre R, Loukola A, Luan J, Lyytikäinen LP, Mangino M, Manichaikul A, Mbarek H, Milaneschi Y, Moayyeri A, Mukamal K, Nelson C, Nettleton J, Partinen E, Rawal R, Robino A, Rose L, Sala C, Satoh T, Schmidt R, Schraut K, Scott R, Smith AV, Starr JM, Teumer A, Trompet S, Uitterlinden AG, Venturini C, Vergnaud AC, Verweij N, Vitart V, Vuckovic D, Wedenoja J, Yengo L, Yu B, Zhang W, Zhao JH, Boomsma DI, Chambers J, Chasman DI, Daniela T, de Geus E, Deary I, Eriksson JG, Esko T, Eulenburg V, Franco OH, Froguel P, Gieger C, Grabe HJ, Gudnason V, Gyllensten U, Harris TB, Hartikainen AL, Heath AC, Hocking L, Hofman A, Huth C, Jarvelin MR, Jukema JW, Kaprio J, Kooner JS, Kutalik Z, Lahti J, Langenberg C, Lehtimäki T, Liu Y, Madden PA, Martin N, Morrison A, Penninx B, Pirastu N, Psaty B, Raitakari O, Ridker P, Rose R, Rotter JI, Samani NJ, Schmidt H, Spector TD, Stott D, Strachan D, Tzoulaki I, van der Harst P, van Duijn CM, Marques-Vidal P, Vollenweider P, Wareham NJ, Whitfield JB, Wilson J, Wolffenbuttel B, Bakalkin G, Evangelou E, Liu Y, Rice KM, Desrivières S, Kliewer SA, Mangelsdorf DJ, Müller CP, Levy D, Elliott P 2016 Dec Proc. Natl. Acad. Sci. U.S.A. 50 113 14372-14377

Impaired 17,20-Lyase Activity in Male Mice Lacking Cytochrome b5 in Leydig Cells.

Sondhi V, Owen BM, Liu J, Chomic R, Kliewer SA, Hughes BA, Arlt W, Mangelsdorf DJ, Auchus RJ 2016 Apr Mol. Endocrinol. 4 30 469-478

Detection of FGF15 in Plasma by Stable Isotope Standards and Capture by Anti-peptide Antibodies and Targeted Mass Spectrometry.

Katafuchi T, Esterházy D, Lemoff A, Ding X, Sondhi V, Kliewer SA, Mirzaei H, Mangelsdorf DJ 2015 Jun Cell Metab. 6 21 898-904

Reflections on the field of metabolism.

Moller DE, Cuervo AM, Gordon J, Froguel P, Mangelsdorf DJ 2015 Apr Cell Metab. 4 21 505-6

Bile Acids as Hormones: The FXR-FGF15/19 Pathway.

Kliewer SA, Mangelsdorf DJ 2015 Dig Dis 3 33 327-31

Loss of the liver X receptor LXRa/? in peripheral sensory neurons modifies energy expenditure.

Mansuy-Aubert V, Gautron L, Lee S, Bookout AL, Kusminski C, Sun K, Zhang Y, Scherer PE, Mangelsdorf DJ, Elmquist JK 2015 Elife 4

Circulating FGF21 is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding.

Markan KR, Naber MC, Ameka MK, Anderegg MD, Mangelsdorf DJ, Kliewer SA, Mohammadi M, Potthoff MJ 2014 Jul Diabetes

Structural insights into gene repression by the orphan nuclear receptor SHP.

Zhi X, Zhou XE, He Y, Zechner C, Suino-Powell KM, Kliewer SA, Melcher K, Mangelsdorf DJ, Xu HE 2014 Jan Proc. Natl. Acad. Sci. U.S.A. 2 111 839-44

Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop.

Patel R, Bookout AL, Magomedova L, Owen BM, Consiglio GP, Shimizu M, Zhang Y, Mangelsdorf DJ, Kliewer SA, Cummins CL 2014 Dec Mol. Endocrinol. me20141259

SnapShot: Hormones of the gastrointestinal tract.

Coate KC, Kliewer SA, Mangelsdorf DJ 2014 Dec Cell 6 159 1478.e1

FGF21 Acts Centrally to Induce Sympathetic Nerve Activity, Energy Expenditure, and Weight Loss.

Owen BM, Ding X, Morgan DA, Coate KC, Bookout AL, Rahmouni K, Kliewer SA, Mangelsdorf DJ 2014 Aug Cell Metab.

PPAR? in Vagal Neurons Regulates High-Fat Diet Induced Thermogenesis.

Liu C, Bookout AL, Lee S, Sun K, Jia L, Lee C, Udit S, Deng Y, Scherer PE, Mangelsdorf DJ, Gautron L, Elmquist JK 2014 Apr Cell Metab. 4 19 722-30

Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice.

Potthoff MJ, Potts A, He T, Duarte JA, Taussig R, Mangelsdorf DJ, Kliewer SA, Burgess SC 2013 Feb Am. J. Physiol. Gastrointest. Liver Physiol. 4 304 G371-80

Nuclear Receptor LRH-1 Induces the Reproductive Neuropeptide Kisspeptin in the Hypothalamus.

Atkin SD, Owen BM, Bookout AL, Cravo RM, Lee C, Elias CF, Elmquist JK, Kliewer SA, Mangelsdorf DJ 2013 Apr Mol. Endocrinol. 4 27 598-605

?Klotho is required for fibroblast growth factor 21 effects on growth and metabolism.

Ding X, Boney-Montoya J, Owen BM, Bookout AL, Coate KC, Mangelsdorf DJ, Kliewer SA 2012 Sep Cell Metab. 3 16 387-93

Sterol-dependent nuclear import of ORP1S promotes LXR regulated trans-activation of apoE.

Lee S, Wang PY, Jeong Y, Mangelsdorf DJ, Anderson RG, Michaely P 2012 Oct Exp. Cell Res. 16 318 2128-42

Nuclear receptors HNF4a and LRH-1 cooperate in regulating Cyp7a1 in vivo.

Kir S, Zhang Y, Gerard RD, Kliewer SA, Mangelsdorf DJ 2012 Nov J. Biol. Chem. 49 287 41334-41

Liver LXRa expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice.

Zhang Y, Breevoort SR, Angdisen J, Fu M, Schmidt DR, Holmstrom SR, Kliewer SA, Mangelsdorf DJ, Schulman IG 2012 May J. Clin. Invest. 5 122 1688-99

Endocrine fibroblast growth factors 15/19 and 21: from feast to famine.

Potthoff MJ, Kliewer SA, Mangelsdorf DJ 2012 Feb Genes Dev. 4 26 312-24

Structural conservation of ligand binding reveals a bile acid-like signaling pathway in nematodes.

Zhi X, Zhou XE, Melcher K, Motola DL, Gelmedin V, Hawdon J, Kliewer SA, Mangelsdorf DJ, Xu HE 2012 Feb J. Biol. Chem. 7 287 4894-903

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor ?

Wei W, Dutchak PA, Wang X, Ding X, Wang X, Bookout AL, Goetz R, Mohammadi M, Gerard RD, Dechow PC, Mangelsdorf DJ, Kliewer SA, Wan Y 2012 Feb

Fibroblast Growth Factor-21 Regulates PPAR? Activity and the Antidiabetic Actions of Thiazolidinediones.

Dutchak PA, Katafuchi T, Bookout AL, Choi JH, Yu RT, Mangelsdorf DJ, Kliewer SA 2012 Feb Cell 3 148 556-67

Research resource: Diagnostic and therapeutic potential of nuclear receptor expression in lung cancer.

Jeong Y, Xie Y, Lee W, Bookout AL, Girard L, Raso G, Behrens C, Wistuba II, Gadzar AF, Minna JD, Mangelsdorf DJ 2012 Aug Mol. Endocrinol. 8 26 1443-54

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice.

Zhang Y, Xie Y, Berglund ED, Coate KC, He TT, Katafuchi T, Xiao G, Potthoff MJ, Wei W, Wan Y, Yu RT, Evans RM, Kliewer SA, Mangelsdorf DJ 2012 Elife 1 e00065

FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1a pathway.

Potthoff MJ, Boney-Montoya J, Choi M, He T, Sunny NE, Satapati S, Suino-Powell K, Xu HE, Gerard RD, Finck BN, Burgess SC, Mangelsdorf DJ, Kliewer SA 2011 Jun Cell Metab. 6 13 729-38

The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling.

Li T, Holmstrom SR, Kir S, Umetani M, Schmidt DR, Kliewer SA, Mangelsdorf DJ 2011 Jun Mol. Endocrinol. 6 25 1066-71

The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity.

Wollam J, Magomedova L, Magner DB, Shen Y, Rottiers V, Motola DL, Mangelsdorf DJ, Cummins CL, Antebi A 2011 Jul 879-84

AKR1B7 is induced by the farnesoid X receptor and metabolizes bile acids.

Schmidt DR, Schmidt S, Holmstrom SR, Makishima M, Yu RT, Cummins CL, Mangelsdorf DJ, Kliewer SA 2011 Jan J. Biol. Chem. 4 286 2425-32

LXR? is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice.

Patel R, Patel M, Tsai R, Lin V, Bookout AL, Zhang Y, Magomedova L, Li T, Chan JF, Budd C, Mangelsdorf DJ, Cummins CL 2011 Jan J. Clin. Invest. 1 121 431-41

LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function.

Holmstrom SR, Deering T, Swift GH, Poelwijk FJ, Mangelsdorf DJ, Kliewer SA, MacDonald RJ 2011 Aug Genes Dev. 16 25 1674-9

Roles of FGF19 in liver metabolism.

Kir S, Kliewer SA, Mangelsdorf DJ 2011 Cold Spring Harb. Symp. Quant. Biol. 76 139-44

Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse.

Fon Tacer K, Bookout AL, Ding X, Kurosu H, John GB, Wang L, Goetz R, Mohammadi M, Kuro-o M, Mangelsdorf DJ, Kliewer SA 2010 Oct Mol. Endocrinol. 10 24 2050-64

Commentary: the year in nuclear receptor control of metabolism.

Mangelsdorf DJ 2010 Nov Mol. Endocrinol. 11 24 2075-80

Regulation of bile acid synthesis by fat-soluble vitamins A and D.

Schmidt DR, Holmstrom SR, Fon Tacer K, Bookout AL, Kliewer SA, Mangelsdorf DJ 2010 May J. Biol. Chem. 19 285 14486-94

Expression profiling of nuclear receptors in the NCI60 cancer cell panel reveals receptor-drug and receptor-gene interactions.

Holbeck S, Chang J, Best AM, Bookout AL, Mangelsdorf DJ, Martinez ED 2010 Jun Mol. Endocrinol. 6 24 1287-96

Fibroblast growth factor 21: from pharmacology to physiology.

Kliewer SA, Mangelsdorf DJ 2010 Jan Am. J. Clin. Nutr. 1 91 254S-257S

Nuclear receptor expression defines a set of prognostic biomarkers for lung cancer.

Jeong Y, Xie Y, Xiao G, Behrens C, Girard L, Wistuba II, Minna JD, Mangelsdorf DJ 2010 PLoS Med. 12 7 e1000378

Chronic diarrhea due to excessive bile acid synthesis and not defective ileal transport: a new syndrome of defective fibroblast growth factor 19 release.

Hofmann AF, Mangelsdorf DJ, Kliewer SA 2009 Nov Clin. Gastroenterol. Hepatol. 11 7 1151-4

Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor.

Sharma KK, Wang Z, Motola DL, Cummins CL, Mangelsdorf DJ, Auchus RJ 2009 May Mol. Endocrinol. 5 23 640-8

Expression profiling of nuclear receptors in human and mouse embryonic stem cells.

Xie CQ, Jeong Y, Fu M, Bookout AL, Garcia-Barrio MT, Sun T, Kim BH, Xie Y, Root S, Zhang J, Xu RH, Chen YE, Mangelsdorf DJ 2009 May Mol. Endocrinol. 5 23 724-33

FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response.

Potthoff MJ, Inagaki T, Satapati S, Ding X, He T, Goetz R, Mohammadi M, Finck BN, Mangelsdorf DJ, Kliewer SA, Burgess SC 2009 Jun Proc. Natl. Acad. Sci. U.S.A. 26 106 10853-8

Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes.

Wang Z, Zhou XE, Motola DL, Gao X, Suino-Powell K, Conneely A, Ogata C, Sharma KK, Auchus RJ, Lok JB, Hawdon JM, Kliewer SA, Xu HE, Mangelsdorf DJ 2009 Jun Proc. Natl. Acad. Sci. U.S.A. 23 106 9138-43

Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas.

McKenna NJ, Cooney AJ, DeMayo FJ, Downes M, Glass CK, Lanz RB, Lazar MA, Mangelsdorf DJ, Moore DD, Qin J, Steffen DL, Tsai MJ, Tsai SY, Yu R, Margolis RN, Evans RM, O'Malley BW 2009 Jun Mol. Endocrinol. 6 23 740-6

MicroRNA let-7 regulates 3T3-L1 adipogenesis.

Sun T, Fu M, Bookout AL, Kliewer SA, Mangelsdorf DJ 2009 Jun Mol. Endocrinol. 6 23 925-31

Nuclear receptor regulation of stemness and stem cell differentiation.

Jeong Y, Mangelsdorf DJ 2009 Aug Exp. Mol. Med. 8 41 525-37

Nuclear hormone receptor regulation of microRNAs controls developmental progression.

Bethke A, Fielenbach N, Wang Z, Mangelsdorf DJ, Antebi A 2009 Apr Science 5923 324 95-8

Nuclear receptors of the enteric tract: guarding the frontier.

Schmidt DR, Mangelsdorf DJ 2008 Oct Nutr. Rev. 10 Suppl 2 66 S88-97

Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis.

Lee YK, Schmidt DR, Cummins CL, Choi M, Peng L, Zhang Y, Goodwin B, Hammer RE, Mangelsdorf DJ, Kliewer SA 2008 Jun Mol. Endocrinol. 6 22 1345-56

Inhibition of growth hormone signaling by the fasting-induced hormone FGF21.

Inagaki T, Lin VY, Goetz R, Mohammadi M, Mangelsdorf DJ, Kliewer SA 2008 Jul Cell Metab. 1 8 77-83

27-hydroxycholesterol is an endogenous selective estrogen receptor modulator.

DuSell CD, Umetani M, Shaul PW, Mangelsdorf DJ, McDonnell DP 2008 Jan Mol. Endocrinol. 1 22 65-77

Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism.

Satapati S, He T, Inagaki T, Potthoff M, Merritt ME, Esser V, Mangelsdorf DJ, Kliewer SA, Browning JD, Burgess SC 2008 Aug Diabetes 8 57 2012-21

Liver X receptor alpha is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype.

Wang H, Zhang Y, Yehuda-Shnaidman E, Medvedev AV, Kumar N, Daniel KW, Robidoux J, Czech MP, Mangelsdorf DJ, Collins S 2008 Apr Mol. Cell. Biol. 7 28 2187-200

Inhibition of growth hormone signaling by the fasting-induced hormone FGF21.

Inagaki, T., Lin, V.Y., Goetz, R., Mohammadi, Mangelsdorf, D.J., Kliewer, S.A. 2008 8 77-83

27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen.

Umetani M, Domoto H, Gormley AK, Yuhanna IS, Cummins CL, Javitt NB, Korach KS, Shaul PW, Mangelsdorf DJ 2007 Oct Nat. Med. 10 13 1185-92

Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids.

Katona BW, Cummins CL, Ferguson AD, Li T, Schmidt DR, Mangelsdorf DJ, Covey DF 2007 Nov J. Med. Chem. 24 50 6048-58

Cardiac peroxisome proliferator-activated receptor gamma is essential in protecting cardiomyocytes from oxidative damage.

Ding G, Fu M, Qin Q, Lewis W, Kim HW, Fukai T, Bacanamwo M, Chen YE, Schneider MD, Mangelsdorf DJ, Evans RM, Yang Q 2007 Nov Cardiovasc. Res. 2 76 269-79

A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling.

Gerisch B, Rottiers V, Li D, Motola DL, Cummins CL, Lehrach H, Mangelsdorf DJ, Antebi A 2007 Mar Proc. Natl. Acad. Sci. U.S.A. 12 104 5014-9

Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21.

Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, Li Y, Goetz R, Mohammadi M, Esser V, Elmquist JK, Gerard RD, Burgess SC, Hammer RE, Mangelsdorf DJ, Kliewer SA 2007 Jun Cell Metab. 6 5 415-25

In vivo imaging of farnesoid X receptor activity reveals the ileum as the primary bile acid signaling tissue.

Houten SM, Volle DH, Cummins CL, Mangelsdorf DJ, Auwerx J 2007 Jun Mol. Endocrinol. 6 21 1312-23

Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice.

Chen W, Chen G, Head DL, Mangelsdorf DJ, Russell DW 2007 Jan Cell Metab. 1 5 73-9

Functional interactions between the Moses corepressor and DHR78 nuclear receptor regulate growth in Drosophila.

Baker KD, Beckstead RB, Mangelsdorf DJ, Thummel CS 2007 Feb Genes Dev. 4 21 450-64

Activation of LXRs prevents bile acid toxicity and cholestasis in female mice.

Uppal H, Saini SP, Moschetta A, Mu Y, Zhou J, Gong H, Zhai Y, Ren S, Michalopoulos GK, Mangelsdorf DJ, Xie W 2007 Feb Hepatology 2 45 422-32

FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption.

Jung D, Inagaki T, Gerard RD, Dawson PA, Kliewer SA, Mangelsdorf DJ, Moschetta A 2007 Dec J. Lipid Res. 12 48 2693-700

Endocrine Regulation of the Fasting Response by PPARalpha-mediated Induction of Fibroblast Growth Factor 21.

Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., Elmquist, J.K., Gerard, R.D., Burgess, S.C., Hammer, R.E., Mangelsdorf, D.J., Kliewer, S.A. 2007 5 415-425

Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands.

Yang C, McDonald JG, Patel A, Zhang Y, Umetani M, Xu F, Westover EJ, Covey DF, Mangelsdorf DJ, Cohen JC, Hobbs HH 2006 Sep J. Biol. Chem. 38 281 27816-26

Identification of a hormonal basis for gallbladder filling.

Choi M, Moschetta A, Bookout AL, Peng L, Umetani M, Holmstrom SR, Suino-Powell K, Xu HE, Richardson JA, Gerard RD, Mangelsdorf DJ, Kliewer SA 2006 Nov Nat. Med. 11 12 1253-5

Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans.

Motola DL, Cummins CL, Rottiers V, Sharma KK, Li T, Li Y, Suino-Powell K, Xu HE, Auchus RJ, Antebi A, Mangelsdorf DJ 2006 Mar Cell 6 124 1209-23

Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor.

Inagaki T, Moschetta A, Lee YK, Peng L, Zhao G, Downes M, Yu RT, Shelton JM, Richardson JA, Repa JJ, Mangelsdorf DJ, Kliewer SA 2006 Mar Proc. Natl. Acad. Sci. U.S.A. 10 103 3920-5

Pregnane X receptor is a target of farnesoid X receptor.

Jung D, Mangelsdorf DJ, Meyer UA 2006 Jul J. Biol. Chem. 28 281 19081-91

Liver X receptors regulate adrenal cholesterol balance.

Cummins CL, Volle DH, Zhang Y, McDonald JG, Sion B, Lefrançois-Martinez AM, Caira F, Veyssière G, Mangelsdorf DJ, Lobaccaro JM 2006 Jul J. Clin. Invest. 7 116 1902-12

High-throughput real-time quantitative reverse transcription PCR.

Bookout AL, Cummins CL, Mangelsdorf DJ, Pesola JM, Kramer MF 2006 Feb Curr Protoc Mol Biol Chapter 15 Unit 15.8

Liver X receptors and cholesterol homoeostasis: spotlight on the adrenal gland.

Cummins CL, Mangelsdorf DJ 2006 Dec Biochem. Soc. Trans. Pt 6 34 1110-3

International Union of Pharmacology. LXIII. Retinoid X receptors.

Germain P, Chambon P, Eichele G, Evans RM, Lazar MA, Leid M, De Lera AR, Lotan R, Mangelsdorf DJ, Gronemeyer H 2006 Dec Pharmacol. Rev. 4 58 760-72

International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor.

Moore DD, Kato S, Xie W, Mangelsdorf DJ, Schmidt DR, Xiao R, Kliewer SA 2006 Dec Pharmacol. Rev. 4 58 742-59

International Union of Pharmacology. LX. Retinoic acid receptors.

Germain P, Chambon P, Eichele G, Evans RM, Lazar MA, Leid M, De Lera AR, Lotan R, Mangelsdorf DJ, Gronemeyer H 2006 Dec Pharmacol. Rev. 4 58 712-25

Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network.

Bookout AL, Jeong Y, Downes M, Yu RT, Evans RM, Mangelsdorf DJ 2006 Aug Cell 4 126 789-99

Nuclear receptor expression links the circadian clock to metabolism.

Yang X, Downes M, Yu RT, Bookout AL, He W, Straume M, Mangelsdorf DJ, Evans RM 2006 Aug Cell 4 126 801-10

Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase.

Rottiers V, Motola DL, Gerisch B, Cummins CL, Nishiwaki K, Mangelsdorf DJ, Antebi A 2006 Apr Dev. Cell 4 10 473-82

Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network.

Bookout, A.L., Jeong, Y., Downes, M., Yu, R.T., Evans, R.M., Mangelsdorf, D.M. 2006 126 789-799

LXRS and FXR: the yin and yang of cholesterol and fat metabolism.

Kalaany NY, Mangelsdorf DJ 2006 Annu. Rev. Physiol. 68 159-91

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.

Inagaki T, Choi M, Moschetta A, Peng L, Cummins CL, McDonald JG, Luo G, Jones SA, Goodwin B, Richardson JA, Gerard RD, Repa JJ, Mangelsdorf DJ, Kliewer SA 2005 Oct Cell Metab. 4 2 217-25

A Nuclear Receptor Atlas: macrophage activation.

Barish GD, Downes M, Alaynick WA, Yu RT, Ocampo CB, Bookout AL, Mangelsdorf DJ, Evans RM 2005 Oct Mol. Endocrinol. 10 19 2466-77

A Nuclear Receptor Atlas: 3T3-L1 adipogenesis.

Fu M, Sun T, Bookout AL, Downes M, Yu RT, Evans RM, Mangelsdorf DJ 2005 Oct Mol. Endocrinol. 10 19 2437-50

Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretion.

Yu L, Gupta S, Xu F, Liverman AD, Moschetta A, Mangelsdorf DJ, Repa JJ, Hobbs HH, Cohen JC 2005 Mar J. Biol. Chem. 10 280 8742-7

Placental expression of the nuclear receptors for oxysterols LXRalpha and LXRbeta during mouse and human development.

Marceau G, Volle DH, Gallot D, Mangelsdorf DJ, Sapin V, Lobaccaro JM 2005 Mar Anat Rec A Discov Mol Cell Evol Biol 1 283 175-81

A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development.

Arai S, Shelton JM, Chen M, Bradley MN, Castrillo A, Bookout AL, Mak PA, Edwards PA, Mangelsdorf DJ, Tontonoz P, Miyazaki T 2005 Mar Cell Metab. 3 1 201-13

Retinoid x receptor heterodimers in the metabolic syndrome.

Shulman AI, Mangelsdorf DJ 2005 Aug N. Engl. J. Med. 6 353 604-15

LXRs regulate the balance between fat storage and oxidation.

Kalaany NY, Gauthier KC, Zavacki AM, Mammen PP, Kitazume T, Peterson JA, Horton JD, Garry DJ, Bianco AC, Mangelsdorf DJ 2005 Apr Cell Metab. 4 1 231-44

Nuclear oxysterol receptors, LXRs, are involved in the maintenance of mouse caput epididymidis structure and functions.

Frenoux JM, Vernet P, Volle DH, Britan A, Saez F, Kocer A, Henry-Berger J, Mangelsdorf DJ, Lobaccaro JM, Drevet JR 2004 Oct J. Mol. Endocrinol. 2 33 361-75

Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase.

Cheng JB, Levine MA, Bell NH, Mangelsdorf DJ, Russell DW 2004 May Proc. Natl. Acad. Sci. U.S.A. 20 101 7711-5

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c.

Watanabe M, Houten SM, Wang L, Moschetta A, Mangelsdorf DJ, Heyman RA, Moore DD, Auwerx J 2004 May J. Clin. Invest. 10 113 1408-18

Structural determinants for vitamin D receptor response to endocrine and xenobiotic signals.

Adachi R, Shulman AI, Yamamoto K, Shimomura I, Yamada S, Mangelsdorf DJ, Makishima M 2004 Jan Mol. Endocrinol. 1 18 43-52

Structural determinants of allosteric ligand activation in RXR heterodimers.

Shulman AI, Larson C, Mangelsdorf DJ, Ranganathan R 2004 Feb Cell 3 116 417-29

Prevention of cholesterol gallstone disease by FXR agonists in a mouse model.

Moschetta A, Bookout AL, Mangelsdorf DJ 2004 Dec Nat. Med. 12 10 1352-8

Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes.

Volle DH, Repa JJ, Mazur A, Cummins CL, Val P, Henry-Berger J, Caira F, Veyssiere G, Mangelsdorf DJ, Lobaccaro JM 2004 Apr Mol. Endocrinol. 4 18 888-98

Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors.

Zhang Y, Repa JJ, Inoue Y, Hayhurst GP, Gonzalez FJ, Mangelsdorf DJ 2004 Apr Mol. Endocrinol. 4 18 851-62

Expression of LRH-1 and SF-1 in the mouse ovary: localization in different cell types correlates with differing function.

Hinshelwood MM, Repa JJ, Shelton JM, Richardson JA, Mangelsdorf DJ, Mendelson CR 2003 Sep Mol. Cell. Endocrinol. 1-2 207 39-45

De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase.

Cheng JB, Motola DL, Mangelsdorf DJ, Russell DW 2003 Sep J. Biol. Chem. 39 278 38084-93

The role of liver X receptor-alpha in the fatty acid regulation of hepatic gene expression.

Pawar A, Botolin D, Mangelsdorf DJ, Jump DB 2003 Oct J. Biol. Chem. 42 278 40736-43

Establishment of a monoclonal antibody for human LXRalpha: Detection of LXRalpha protein expression in human macrophages.

Watanabe Y, Tanaka T, Uchiyama Y, Takeno T, Izumi A, Yamashita H, Kumakura J, Iwanari H, Shu-Ying J, Naito M, Mangelsdorf DJ, Hamakubo T, Kodama T 2003 May Nucl. Recept. 1 1 1

Interaction between vitamin D receptor and vitamin D ligands: two-dimensional alanine scanning mutational analysis.

Choi M, Yamamoto K, Itoh T, Makishima M, Mangelsdorf DJ, Moras D, DeLuca HF, Yamada S 2003 Mar Chem. Biol. 3 10 261-70

Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages.

Castrillo A, Joseph SB, Marathe C, Mangelsdorf DJ, Tontonoz P 2003 Mar J. Biol. Chem. 12 278 10443-9

The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway.

Baker KD, Shewchuk LM, Kozlova T, Makishima M, Hassell A, Wisely B, Caravella JA, Lambert MH, Reinking JL, Krause H, Thummel CS, Willson TM, Mangelsdorf DJ 2003 Jun Cell 6 113 731-42

Liver X receptor signaling pathways in cardiovascular disease.

Tontonoz P, Mangelsdorf DJ 2003 Jun Mol. Endocrinol. 6 17 985-93

Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor.

Goodwin B, Gauthier KC, Umetani M, Watson MA, Lochansky MI, Collins JL, Leitersdorf E, Mangelsdorf DJ, Kliewer SA, Repa JJ 2003 Jan Proc. Natl. Acad. Sci. U.S.A. 1 100 223-8

Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production.

Fowler AJ, Sheu MY, Schmuth M, Kao J, Fluhr JW, Rhein L, Collins JL, Willson TM, Mangelsdorf DJ, Elias PM, Feingold KR 2003 Feb J. Invest. Dermatol. 2 120 246-55

Reciprocal regulation of inflammation and lipid metabolism by liver X receptors.

Joseph SB, Castrillo A, Laffitte BA, Mangelsdorf DJ, Tontonoz P 2003 Feb Nat. Med. 2 9 213-9

Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue.

Laffitte BA, Chao LC, Li J, Walczak R, Hummasti S, Joseph SB, Castrillo A, Wilpitz DC, Mangelsdorf DJ, Collins JL, Saez E, Tontonoz P 2003 Apr Proc. Natl. Acad. Sci. U.S.A. 9 100 5419-24

Quantitative real-time PCR protocol for analysis of nuclear receptor signaling pathways.

Bookout AL, Mangelsdorf DJ 2003 Nucl Recept Signal 1 e012

PPAR alpha is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue.

Lee Y, Yu X, Gonzales F, Mangelsdorf DJ, Wang MY, Richardson C, Witters LA, Unger RH 2002 Sep Proc. Natl. Acad. Sci. U.S.A. 18 99 11848-53

Identification of macrophage liver X receptors as inhibitors of atherosclerosis.

Tangirala RK, Bischoff ED, Joseph SB, Wagner BL, Walczak R, Laffitte BA, Daige CL, Thomas D, Heyman RA, Mangelsdorf DJ, Wang X, Lusis AJ, Tontonoz P, Schulman IG 2002 Sep Proc. Natl. Acad. Sci. U.S.A. 18 99 11896-901

Fatty acid regulation of liver X receptors (LXR) and peroxisome proliferator-activated receptor alpha (PPARalpha ) in HEK293 cells.

Pawar A, Xu J, Jerks E, Mangelsdorf DJ, Jump DB 2002 Oct J. Biol. Chem. 42 277 39243-50

The liver X receptor gene team: potential new players in atherosclerosis.

Repa JJ, Mangelsdorf DJ 2002 Nov Nat. Med. 11 8 1243-8

A natural product that lowers cholesterol as an antagonist ligand for FXR.

Urizar NL, Liverman AB, Dodds DT, Silva FV, Ordentlich P, Yan Y, Gonzalez FJ, Heyman RA, Mangelsdorf DJ, Moore DD 2002 May Science 5573 296 1703-6

Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta.

Repa JJ, Berge KE, Pomajzl C, Richardson JA, Hobbs H, Mangelsdorf DJ 2002 May J. Biol. Chem. 21 277 18793-800

Vitamin D receptor as an intestinal bile acid sensor.

Makishima M, Lu TT, Xie W, Whitfield GK, Domoto H, Evans RM, Haussler MR, Mangelsdorf DJ 2002 May Science 5571 296 1313-6

Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor.

Jung D, Podvinec M, Meyer UA, Mangelsdorf DJ, Fried M, Meier PJ, Kullak-Ublick GA 2002 Jun Gastroenterology 7 122 1954-66

Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis.

Kömüves LG, Schmuth M, Fowler AJ, Elias PM, Hanley K, Man MQ, Moser AH, Lobaccaro JM, Williams ML, Mangelsdorf DJ, Feingold KR 2002 Jan J. Invest. Dermatol. 1 118 25-34

Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta.

Mak PA, Laffitte BA, Desrumaux C, Joseph SB, Curtiss LK, Mangelsdorf DJ, Tontonoz P, Edwards PA 2002 Aug J. Biol. Chem. 35 277 31900-8

LuXuRies of lipid homeostasis: the unity of nuclear hormone receptors, transcription regulation, and cholesterol sensing.

Zhang Y, Mangelsdorf DJ 2002 Apr Mol. Interv. 2 2 78-87

The generation of monoclonal antibodies against human peroxisome proliferator-activated receptors (PPARs).

Tanaka T, Takeno T, Watanabe Y, Uchiyama Y, Murakami T, Yamashita H, Suzuki A, Aoi R, Iwanari H, Jiang SY, Naito M, Tachibana K, Doi T, Shulman AI, Mangelsdorf DJ, Reiter R, Auwerx J, Hamakubo T, Kodama T 2002 J. Atheroscler. Thromb. 5 9 233-42

Prospects for prevention and treatment of cancer with selective PPARgamma modulators (SPARMs).

Sporn MB, Suh N, Mangelsdorf DJ 2001 Sep Trends Mol Med 9 7 395-400

Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism.

Lu TT, Repa JJ, Mangelsdorf DJ 2001 Oct J. Biol. Chem. 41 276 37735-8

Nuclear receptors and lipid physiology: opening the X-files.

Chawla A, Repa JJ, Evans RM, Mangelsdorf DJ 2001 Nov Science 5548 294 1866-70

Engineering orthogonal ligand-receptor pairs from "near drugs".

Doyle DF, Braasch DA, Jackson LK, Weiss HE, Boehm MF, Mangelsdorf DJ, Corey DR 2001 Nov J. Am. Chem. Soc. 46 123 11367-71

Regulation of lipoprotein lipase by the oxysterol receptors, LXRalpha and LXRbeta.

Zhang Y, Repa JJ, Gauthier K, Mangelsdorf DJ 2001 Nov J. Biol. Chem. 46 276 43018-24

[Regulation of lipid metabolism by the orphan nuclear receptors].

Lobaccaro JM, Repa JJ, Lu TT, Caira F, Henry-Berger J, Volle DH, Mangelsdorf DJ 2001 Jun Ann. Endocrinol. (Paris) 3 62 239-47

The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp.

Denson LA, Sturm E, Echevarria W, Zimmerman TL, Makishima M, Mangelsdorf DJ, Karpen SJ 2001 Jul Gastroenterology 1 121 140-7

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes.

Laffitte BA, Repa JJ, Joseph SB, Wilpitz DC, Kast HR, Mangelsdorf DJ, Tontonoz P 2001 Jan Proc. Natl. Acad. Sci. U.S.A. 2 98 507-12

Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor.

Claudel T, Leibowitz MD, Fiévet C, Tailleux A, Wagner B, Repa JJ, Torpier G, Lobaccaro JM, Paterniti JR, Mangelsdorf DJ, Heyman RA, Auwerx J 2001 Feb Proc. Natl. Acad. Sci. U.S.A. 5 98 2610-5

Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor.

Ananthanarayanan M, Balasubramanian N, Makishima M, Mangelsdorf DJ, Suchy FJ 2001 Aug J. Biol. Chem. 31 276 28857-65

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors.

Lu TT, Makishima M, Repa JJ, Schoonjans K, Kerr TA, Auwerx J, Mangelsdorf DJ 2000 Sep Mol. Cell 3 6 507-15

Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers.

Repa JJ, Turley SD, Lobaccaro JA, Medina J, Li L, Lustig K, Shan B, Heyman RA, Dietschy JM, Mangelsdorf DJ 2000 Sep Science 5484 289 1524-9

Stress pathway activation induces phosphorylation of retinoid X receptor.

Lee HY, Suh YA, Robinson MJ, Clifford JL, Hong WK, Woodgett JR, Cobb MH, Mangelsdorf DJ, Kurie JM 2000 Oct J. Biol. Chem. 41 275 32193-9

A synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), is a ligand for the peroxisome proliferator-activated receptor gamma.

Wang Y, Porter WW, Suh N, Honda T, Gribble GW, Leesnitzer LM, Plunket KD, Mangelsdorf DJ, Blanchard SG, Willson TM, Sporn MB 2000 Oct Mol. Endocrinol. 10 14 1550-6

Role of LXRs in control of lipogenesis.

Schultz JR, Tu H, Luk A, Repa JJ, Medina JC, Li L, Schwendner S, Wang S, Thoolen M, Mangelsdorf DJ, Lustig KD, Shan B 2000 Nov Genes Dev. 22 14 2831-8

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta.

Repa JJ, Liang G, Ou J, Bashmakov Y, Lobaccaro JM, Shimomura I, Shan B, Brown MS, Goldstein JL, Mangelsdorf DJ 2000 Nov Genes Dev. 22 14 2819-30

Transcriptional activation of the Drosophila ecdysone receptor by insect and plant ecdysteroids.

Baker KD, Warren JT, Thummel CS, Gilbert LI, Mangelsdorf DJ 2000 Nov Insect Biochem. Mol. Biol. 11 30 1037-43

Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols.

Venkateswaran A, Repa JJ, Lobaccaro JM, Bronson A, Mangelsdorf DJ, Edwards PA 2000 May J. Biol. Chem. 19 275 14700-7

Interleukin-1beta suppresses retinoid transactivation of two hepatic transporter genes involved in bile formation.

Denson LA, Auld KL, Schiek DS, McClure MH, Mangelsdorf DJ, Karpen SJ 2000 Mar J. Biol. Chem. 12 275 8835-43

Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription.

Hanley K, Ng DC, He SS, Lau P, Min K, Elias PM, Bikle DD, Mangelsdorf DJ, Williams ML, Feingold KR 2000 Mar J. Invest. Dermatol. 3 114 545-53

Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver.

Wan YJ, An D, Cai Y, Repa JJ, Hung-Po Chen T, Flores M, Postic C, Magnuson MA, Chen J, Chien KR, French S, Mangelsdorf DJ, Sucov HM 2000 Jun Mol. Cell. Biol. 12 20 4436-44

Modifying ligand specificity of gene regulatory proteins.

Doyle DF, Mangelsdorf DJ, Corey DR 2000 Feb Curr Opin Chem Biol 1 4 60-3

The role of orphan nuclear receptors in the regulation of cholesterol homeostasis.

Repa JJ, Mangelsdorf DJ 2000 Annu. Rev. Cell Dev. Biol. 16 459-81

Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers

Repa, J.J., Turley, S.D., Lobaccaro, J.A., Medina, J., Li, L., Lustig, K., Shan , B., Heyman, R.A., Dietschy, J.M., and Mangelsdorf, D.J. 2000 289 1524-1529

Identification of a nuclear receptor for bile acids.

Makishima M, Okamoto AY, Repa JJ, Tu H, Learned RM, Luk A, Hull MV, Lustig KD, Mangelsdorf DJ, Shan B 1999 May Science 5418 284 1362-5

All-trans-retinoic acid inhibits Jun N-terminal kinase by increasing dual-specificity phosphatase activity.

Lee HY, Sueoka N, Hong WK, Mangelsdorf DJ, Claret FX, Kurie JM 1999 Mar Mol. Cell. Biol. 3 19 1973-80

A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity.

Suh N, Wang Y, Honda T, Gribble GW, Dmitrovsky E, Hickey WF, Maue RA, Place AE, Porter DM, Spinella MJ, Williams CR, Wu G, Dannenberg AJ, Flanders KC, Letterio JJ, Mangelsdorf DJ, Nathan CF, Nguyen L, Porter WW, Ren RF, Roberts AB, Roche NS, Subbaramaiah K, Sporn MB 1999 Jan Cancer Res. 2 59 336-41

Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta.

Janowski BA, Grogan MJ, Jones SA, Wisely GB, Kliewer SA, Corey EJ, Mangelsdorf DJ 1999 Jan Proc. Natl. Acad. Sci. U.S.A. 1 96 266-71

Nuclear receptor regulation of cholesterol and bile acid metabolism.

Repa JJ, Mangelsdorf DJ 1999 Dec Curr. Opin. Biotechnol. 6 10 557-63

The LXRs: a new class of oxysterol receptors.

Peet DJ, Janowski BA, Mangelsdorf DJ 1998 Oct Curr. Opin. Genet. Dev. 5 8 571-5

Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha.

Peet DJ, Turley SD, Ma W, Janowski BA, Lobaccaro JM, Hammer RE, Mangelsdorf DJ 1998 May Cell 5 93 693-704

Engineering novel specificities for ligand-activated transcription in the nuclear hormone receptor RXR.

Peet DJ, Doyle DF, Corey DR, Mangelsdorf DJ 1998 Jan Chem. Biol. 1 5 13-21

Isolation of two functional retinoid X receptor subtypes from the Ixodid tick, Amblyomma americanum (L.).

Guo X, Xu Q, Harmon MA, Jin X, Laudet V, Mangelsdorf DJ, Palmer MJ 1998 Apr Mol. Cell. Endocrinol. 1-2 139 45-60

Characterization of a region upstream of exon I.1 of the human CYP19 (aromatase) gene that mediates regulation by retinoids in human choriocarcinoma cells.

Sun T, Zhao Y, Mangelsdorf DJ, Simpson ER 1998 Apr Endocrinology 4 139 1684-91

Trypanosoma brucei: effects of methoprene and other isoprenoid compounds on procyclic and bloodstream forms in vitro and in mice.

Harmon MA, Scott TC, Li Y, Boehm MF, Phillips MA, Mangelsdorf DJ 1997 Nov Exp. Parasitol. 3 87 229-36

Isolation of a functional ecdysteroid receptor homologue from the ixodid tick Amblyomma americanum (L.).

Guo X, Harmon MA, Laudet V, Mangelsdorf DJ, Palmer MJ 1997 Nov Insect Biochem. Mol. Biol. 11 27 945-62

Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols.

Lala DS, Syka PM, Lazarchik SB, Mangelsdorf DJ, Parker KL, Heyman RA 1997 May Proc. Natl. Acad. Sci. U.S.A. 10 94 4895-900

Retinoic acid receptor expression abnormalities in lung cancer: important clues or major obstacles?

Minna JD, Mangelsdorf DJ 1997 May J. Natl. Cancer Inst. 9 89 602-4

Unique requirements for retinoid-dependent transcriptional activation by the orphan receptor LXR.

Willy PJ, Mangelsdorf DJ 1997 Feb Genes Dev. 3 11 289-98

An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha.

Janowski BA, Willy PJ, Devi TR, Falck JR, Mangelsdorf DJ 1996 Oct Nature 6602 383 728-31

LXR, a nuclear receptor that defines a distinct retinoid response pathway.

Willy PJ, Umesono K, Ong ES, Evans RM, Heyman RA, Mangelsdorf DJ 1995 May Genes Dev. 9 9 1033-45

Activation of mammalian retinoid X receptors by the insect growth regulator methoprene.

Harmon MA, Boehm MF, Heyman RA, Mangelsdorf DJ 1995 Jun Proc. Natl. Acad. Sci. U.S.A. 13 92 6157-60

The RXR heterodimers and orphan receptors.

Mangelsdorf DJ, Evans RM 1995 Dec Cell 6 83 841-50

The nuclear receptor superfamily: the second decade.

Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schütz G, Umesono K, Blumberg B, Kastner P, Mark M, Chambon P, Evans RM 1995 Dec Cell 6 83 835-9

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.

Kliewer SA, Forman BM, Blumberg B, Ong ES, Borgmeyer U, Mangelsdorf DJ, Umesono K, Evans RM 1994 Jul Proc. Natl. Acad. Sci. U.S.A. 15 91 7355-9

Vitamin A receptors.

Mangelsdorf DJ 1994 Feb Nutr. Rev. 2 Pt 2 52 S32-44

Chromosomal localization of the human retinoid X receptors.

Almasan A, Mangelsdorf DJ, Ong ES, Wahl GM, Evans RM 1994 Apr Genomics 3 20 397-403

Retinoid receptors.

Mangelsdorf DJ, Kliewer SA, Kakizuka A, Umesono K, Evans RM 1993 Recent Prog. Horm. Res. 48 99-121

Multiple retinoid-responsive receptors in a single cell: families of retinoid "X" receptors and retinoic acid receptors in the Xenopus egg.

Blumberg B, Mangelsdorf DJ, Dyck JA, Bittner DA, Evans RM, De Robertis EM 1992 Mar Proc. Natl. Acad. Sci. U.S.A. 6 89 2321-5

Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.

Mangelsdorf DJ, Borgmeyer U, Heyman RA, Zhou JY, Ong ES, Oro AE, Kakizuka A, Evans RM 1992 Mar Genes Dev. 3 6 329-44

Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling.

Kliewer SA, Umesono K, Mangelsdorf DJ, Evans RM 1992 Jan Nature 6359 355 446-9

9-cis retinoic acid is a high affinity ligand for the retinoid X receptor.

Heyman RA, Mangelsdorf DJ, Dyck JA, Stein RB, Eichele G, Evans RM, Thaller C 1992 Jan Cell 2 68 397-406

Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling.

Kliewer SA, Umesono K, Heyman RA, Mangelsdorf DJ, Dyck JA, Evans RM 1992 Feb Proc. Natl. Acad. Sci. U.S.A. 4 89 1448-52

Characterization of DNA binding and retinoic acid binding properties of retinoic acid receptor.

Yang N, Schüle R, Mangelsdorf DJ, Evans RM 1991 May Proc. Natl. Acad. Sci. U.S.A. 9 88 3559-63

A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR.

Mangelsdorf DJ, Umesono K, Kliewer SA, Borgmeyer U, Ong ES, Evans RM 1991 Aug Cell 3 66 555-61

Nuclear receptor that identifies a novel retinoic acid response pathway.

Mangelsdorf DJ, Ong ES, Dyck JA, Evans RM 1990 May Nature 6272 345 224-9

Jun-Fos and receptors for vitamins A and D recognize a common response element in the human osteocalcin gene.

Schüle R, Umesono K, Mangelsdorf DJ, Bolado J, Pike JW, Evans RM 1990 May Cell 3 61 497-504

A functional retinoic acid receptor encoded by the gene on human chromosome 12.

Ishikawa T, Umesono K, Mangelsdorf DJ, Aburatani H, Stanger BZ, Shibasaki Y, Imawari M, Evans RM, Takaku F 1990 Jun Mol. Endocrinol. 6 4 837-44

Identification and regulation of 1,25-dihydroxyvitamin D3 receptor activity and biosynthesis of 1,25-dihydroxyvitamin D3. Studies in cultured bovine aortic endothelial cells and human dermal capillaries.

Merke J, Milde P, Lewicka S, Hügel U, Klaus G, Mangelsdorf DJ, Haussler MR, Rauterberg EW, Ritz E 1989 Jun J. Clin. Invest. 6 83 1903-15

Cloning and expression of full-length cDNA encoding human vitamin D receptor.

Baker AR, McDonnell DP, Hughes M, Crisp TM, Mangelsdorf DJ, Haussler MR, Pike JW, Shine J, O'Malley BW 1988 May Proc. Natl. Acad. Sci. U.S.A. 10 85 3294-8

Evidence for in vivo upregulation of the intestinal vitamin D receptor during dietary calcium restriction in the rat.

Favus MJ, Mangelsdorf DJ, Tembe V, Coe BJ, Haussler MR 1988 Jul J. Clin. Invest. 1 82 218-24

Molecular biology of the vitamin D hormone.

Haussler MR, Mangelsdorf DJ, Komm BS, Terpening CM, Yamaoka K, Allegretto EA, Baker AR, Shine J, McDonnell DP, Hughes M 1988 Recent Prog. Horm. Res. 44 263-305

Molecular cloning of complementary DNA encoding the avian receptor for vitamin D.

McDonnell DP, Mangelsdorf DJ, Pike JW, Haussler MR, O'Malley BW 1987 Mar Science 4793 235 1214-7

Avian and mammalian receptors for 1,25-dihydroxyvitamin D3: in vitro translation to characterize size and hormone-dependent regulation.

Mangelsdorf DJ, Pike JW, Haussler MR 1987 Jan Proc. Natl. Acad. Sci. U.S.A. 2 84 354-8

Immunoselection of cDNAs to avian intestinal calcium binding protein 28K and a novel calmodulin-like protein: assessment of mRNA regulation by the vitamin D hormone.

Mangelsdorf DJ, Komm BS, McDonnell DP, Pike JW, Haussler MR 1987 Dec Biochemistry 25 26 8332-8

1,25-Dihydroxyvitamin D3 receptors: altered functional domains are associated with cellular resistance to vitamin D3.

Pike JW, Allegretto EA, Kelly MA, Donaldson CA, Marion SL, Mangelsdorf DJ, Haussler MR 1986 Adv. Exp. Med. Biol. 196 377-90

1,25-Dihydroxyvitamin D3 receptors in space-flown vs. grounded control rat kidneys.

Mangelsdorf DJ, Marion SL, Pike JW, Haussler MR 1985 Dec Physiologist 6 Suppl 28 S223-4

Identification and quantitation of intracellular retinol and retinoic acid binding proteins in cultured cells.

Haussler MR, Donaldson CA, Kelly MA, Mangelsdorf DJ, Bowden GT, Meinke WJ, Meyskens FL, Sidell N 1984 Feb Biochim. Biophys. Acta 1-2 803 54-62

1,25-Dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL-60): receptor-mediated maturation to macrophage-like cells.

Mangelsdorf DJ, Koeffler HP, Donaldson CA, Pike JW, Haussler MR 1984 Feb J. Cell Biol. 2 98 391-8