Kim (Jaehyup) Lab

PD-1

Meet the Principal Investigator

Kim

Jaehyup Kim, M.D., Ph.D.

Assistant Professor of Pathology

        During my postdoctoral training under Dr Chengcheng (Alec) Zhang (Department of Physiology), I used several techniques including flow cytometry, mass spectrometry and co-immunoprecipitation to study the biology of immune regulatory receptors. I helped identify the ligand of LILRB4 for the first time, which was published in the journal Nature with me as a co-first author (Mi et al, Nature 2018).

        Following the completion of my clinical training and post-doctoral research training, I started my own independent lab with the support from NIH Mentored Clinical Scientist Research Career Development Award (5K08CA234544-04, The role of LILRB4 in AML progression and immune suppression).

       My lab studies the mechanism of immune regulatory receptor regulation with a special focus on ligand identification and modulation. We have identified a novel class of ligands capable of activating various Ig-like domain containing receptors including PD-1 and TIM-3. Currently, my lab is working on clarifying the contribution of these ligands in various pathological processes including cancer and graft-versus-host disease.

Research Focus

  • Discover novel ligands for Immune regulatory receptors
  • Identify ligands with immune cell subset specific/preferential binding characteristics
  • Leverage the difference in ligand binding affinity for clinical applications

Faculty Profile

Lab Members

Hsin-yi Chen

Research Scientist

Chen

Hye-jeong Cho

Senior Research Associate

Cho

Publications

LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration.

Deng M, Gui X, Kim J, Xie L, Chen W, Li Z, He L, Chen Y, Chen H, Luo W, Lu Z, Xie J, Churchill H, Xu Y, Zhou Z, Wu G, Yu C, John S, Hirayasu K, Nguyen N, Liu X, Huang F, Li L, Deng H, Tang H, Sadek AH, Zhang L, Huang T, Zou Y, Chen B, Zhu H, Arase H, Xia N, Jiang Y, Collins R, You MJ, Homsi J, Unni N, Lewis C, Chen GQ, Fu YX, Liao XC, An Z, Zheng J, Zhang N, Zhang CC 2018 Oct Nature 7728 562 605-609

Mathematical calculation of lifespan of transfused RBCs in sickle cell disease patients.

Kim J, Usmani A, De Simone N, Sarode R 2018 Feb Transfus. Apher. Sci. 1 57 46-49

Human Mesenchymal Stem Cell-Educated Macrophages Are a Distinct High IL-6-Producing Subset that Confer Protection in Graft-versus-Host-Disease and Radiation Injury Models.

Bouchlaka MN, Moffitt AB, Kim J, Kink JA, Bloom DD, Love C, Dave S, Hematti P, Capitini CM 2017 Jun Biol. Blood Marrow Transplant. 6 23 897-905

Extracellular Superoxide Dismutase Expression in Papillary Thyroid Cancer Mesenchymal Stem/Stromal Cells Modulates Cancer Cell Growth and Migration.

Parascandolo A, Rappa F, Cappello F, Kim J, Cantu DA, Chen H, Mazzoccoli G, Hematti P, Castellone MD, Salvatore M, Laukkanen MO 2017 Feb Sci Rep 7 41416

Comparison of Spectra Optia and COBE Spectra apheresis systems' performances for red blood cell exchange procedures.

Kim J, Joseph R, Matevosyan K, Sarode R 2016 Dec Transfus. Apher. Sci. 3 55 368-370

Autosomal short tandem repeat analysis of ancient DNA by coupled use of mini- and conventional STR kits.

Oh CS, Lee SJ, Park JB, Lee SD, Seo SB, Kim HY, Kim J, Kim YS, Shin DH 2012 May J. Forensic Sci. 3 57 820-5

The effect of mesenchymal stromal cell-hyaluronic acid hydrogel constructs on immunophenotype of macrophages.

Hanson SE, King SN, Kim J, Chen X, Thibeault SL, Hematti P 2011 Oct Tissue Eng Part A 19-20 17 2463-71

Mesenchymal stromal cells are present in the heart and promote growth of adult stem cells in vitro.

Lushaj EB, Anstadt E, Haworth R, Roenneburg D, Kim J, Hematti P, Kohmoto T 2011 Apr Cytotherapy 4 13 400-6

Characterization of mesenchymal stem cells from human vocal fold fibroblasts.

Hanson SE, Kim J, Johnson BH, Bradley B, Breunig MJ, Hematti P, Thibeault SL 2010 Mar Laryngoscope 3 120 546-51

Bone marrow stromal cells from multiple myeloma patients uniquely induce bortezomib resistant NF-kappaB activity in myeloma cells.

Markovina S, Callander NS, O'Connor SL, Xu G, Shi Y, Leith CP, Kim K, Trivedi P, Kim J, Hematti P, Miyamoto S 2010 Jul Mol. Cancer 9 176

Dental caries prevalence of medieval Korean people.

Han SS, Baek KW, Shin MH, Kim J, Oh CS, Lee SJ, Shin DH 2010 Jul Arch. Oral Biol. 7 55 535-40

Mesenchymal stem cell-educated macrophages: a novel type of alternatively activated macrophages.

Kim J, Hematti P 2009 Dec Exp. Hematol. 12 37 1445-53

Reactive astrocytes expressing intense estrogen receptor-alpha immunoreactivities have much elongated cytoplasmic processes: an autopsy case of human cerebellar tissue with multiple genitourinary and gastrointestinal anomalies.

Kim EJ, Oh CS, Kim J, Kim WH, Chung YH, Shin DH 2007 Oct J. Korean Med. Sci. 5 22 936-41

Immunocytochemical study on the distribution of c-myb in the central nervous system of the transgenic mice expressing a human copper/zinc superoxide dismutase mutation.

Shin DH, Lee E, Joo KM, Kim J, Bae SR, Chung YH, Cha CI 2003 Oct Neurosci. Lett. 3 350 149-52

The correspondence between the labeling patterns of antibody RT97, neurofilaments, microtubule associated protein 1B and tau varies with cell types and development stages of chicken retina.

Shin DH, Lee KS, Lee E, Cho SS, Kim J, Kim JW, Kwon BS, Lee HW, Lee WJ 2003 May Neurosci. Lett. 3 342 167-70

Heat shock protein 108 mRNA expression during chicken retina development.

Shin DH, Kim HJ, Kim J, Bae SR, Cho SS 2003 Jun Neurosci. Lett. 1 344 25-8

Vasoactive intestinal peptide (VIP) and VIP mRNA decrease in the cerebral cortex of nNOS knock-out(-/-) mice.

Kim MJ, Joo KM, Chung YH, Lee YJ, Kim J, Lee BH, Shin DH, Lee KH, Cha CI 2003 Jul Brain Res. 1-2 978 233-40

Ultramicroscopical immunolocalization of PAX6 in the adult chicken retina.

Shin DH, Kwon BS, Chang YP, Bae SR, Kim J, Kim JW 2003 Acta Histochem. 3 105 267-72

Contact Us

Email address: jaehyup.kim@utsouthwestern.edu
Phone Number: 214-648-4115
Lab Location: NB7.226

Mailing Address
Jaehyup Kim Lab, NB7.226
5323 Harry Hines Blvd.
Dallas, TX 75390-9072