Publications

A HFD suppresses de novo lipogenesis and desaturation, but not elongation and triglyceride synthesis in mice.

Duarte JA, Carvalho F, Pearson M, Horton JD, Browning JD, Jones JG, Burgess SC 2014 Sep J. Lipid Res.

Deletion of ELOVL6 Blocks the Synthesis of Oleic Acid but does not Prevent the Development of Fatty Liver or Insulin Resistance.

Moon YA, Ochoa CR, Mitsche MA, Hammer RE, Horton JD 2014 Oct J. Lipid Res.

Hepatic gluconeogenesis is enhanced by phosphatidic Acid which remains uninhibited by insulin in lipodystrophic agpat2-/- mice.

Sankella S, Garg A, Horton JD, Agarwal AK 2014 Feb J. Biol. Chem. 8 289 4762-77

Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2-/- lipodystrophic mice independent of hepatocyte leptin receptors.

Cortés VA, Cautivo KM, Rong S, Garg A, Horton JD, Agarwal AK 2014 Feb J. Lipid Res. 2 55 276-88

An acetate switch regulates stress erythropoiesis.

Xu M, Nagati JS, Xie J, Li J, Walters H, Moon YA, Gerard RD, Huang CL, Comerford SA, Hammer RE, Horton JD, Chen R, Garcia JA 2014 Aug Nat. Med.

Inhibition of PCSK9 does not improve lipopolysaccharide-induced mortality in mice.

Berger JM, Loza Valdes A, Gromada J, Anderson N, Horton JD 2017 Jun J. Lipid Res.

Expression of SREBP-1c requires SREBP-2-mediated generation of a sterol ligand for LXR in livers of mice.

Rong S, Cortés VA, Rashid S, Anderson NN, McDonald JG, Liang G, Moon YA, Hammer RE, Horton JD 2017 Feb Elife 6

Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.

Kim CW, Addy C, Kusunoki J, Anderson NN, Deja S, Fu X, Burgess SC, Li C, Ruddy M, Chakravarthy M, Previs S, Milstein S, Fitzgerald K, Kelley DE, Horton JD 2017 Aug Cell Metab. 2 26 394-406.e6

A Highly Durable RNAi Therapeutic Inhibitor of PCSK9.

Fitzgerald K, White S, Borodovsky A, Bettencourt BR, Strahs A, Clausen V, Wijngaard P, Horton JD, Taubel J, Brooks A, Fernando C, Kauffman RS, Kallend D, Vaishnaw A, Simon A 2016 Nov N. Engl. J. Med.

AGPAT2 is essential for postnatal development and maintenance of white and brown adipose tissue.

Cautivo KM, Lizama CO, Tapia PJ, Agarwal AK, Garg A, Horton JD, Cortés VA 2016 Jul Mol Metab 7 5 491-505

Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial.

Fitzgerald K, Frank-Kamenetsky M, Shulga-Morskaya S, Liebow A, Bettencourt BR, Sutherland JE, Hutabarat RM, Clausen VA, Karsten V, Cehelsky J, Nochur SV, Kotelianski V, Horton J, Mant T, Chiesa J, Ritter J, Munisamy M, Vaishnaw AK, Gollob JA, Simon A 2014 Jan Lancet 9911 383 60-8

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