Grants
- Grant Number R01HL148448 – Blood and Urine Biomarkers for Predicting Long-Term Adverse Kidney and Cardiovascular Outcomes after Cardiac Surgery.
The goal of this research is to identify blood and urine biomarkers and clinical variables that predict with high sensitivity and specificity those patients who develop major adverse kidney and/or cardiovascular outcomes during the 5 years following cardiac surgery. 610 cardiac surgical patients were prospectively enrolled for this grant work, up to five year follow-up is ongoing. Project Period: May 2019 – April 2024. - O’Brien Kidney Center Pilot and Feasibility Grant Awarded from NIH UT Southwestern P30DK0793228
Project Period: 2016-2018
Honors & Awards
Year |
Name of Honor/Award |
Awarding Organization |
| 2015-Present | A.H. "Buddy" Giesecke, Jr., M.D. Distinguished Professorship in Anesthesiology and Pain Management | University of Texas Southwestern Medical Center |
| 2019 | Abstract selected for the Annual Meeting’s Best of 2019 Session | Society of Cardiovascular Anesthesiologists Annual Meeting. One of the top 16 scientific abstracts. (last author) |
| 2018 | Research Faculty of the Year | Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center |
| 2018 | Society of Cardiovsacular Anesthesiologists (SCA) Newsletter Member Spotlight Article | Featured in “Member Spotlight- AWEsome Women (Anesthesiology Women of Excellence)” series. SCA Newsletter vol. 17(4), August 2018 |
| 2016 | Chairman’s Recognition Award | Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center |
| 2016 | Clinician of the Month – December | Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center |
| 2014 | Best Research Abstract of Meeting Award | International Anesthesia Research Society Annual Meeting, May 19th, 2014 in Montreal, Canada. Selected as best abstract and research presentation out of >500 accepted abstracts. (first author) |
| 2011 | Abstract selected for the Annual Meeting’s Best of 2011 Session | Society of Cardiovascular Anesthesiologists Annual Meeting. One of 10 abstracts selected. (first author) |
| 2009 | Research Program Award | American Heart Association, Founders Affiliate Clinical Research Program Award (Principal investigator) declined grant in order to accept American Geriatrics Society Grant award, as the two grants had overlapping specific aims). Grant would have provided $50,000 per year for two years. |
| 2008 | Best Abstracts of the Meeting – Anesthesiology Editors’ Pick | American Society of Anesthesiologists’ Annual Meeting. One of 10 abstracts accepted for oral presentation. (first author) |
| 2005 | Faculty Excellence Award | Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA |
| 1994 | Phi Beta Kappa | Stanford University, Palo Alto, CA |
Grant Review Activities
2020-2023, 2018-2019
Invited Grant Reviewer and FAER Grant Review Study Section member (Spring 2018; Spring 2019; Fall 2019; Spring 2021; Fall 2021; Spring 2022; Fall 2022; Spring 2023)
Organization:
Foundation for Anesthesia Education (FAER) and Research Grant Program
American Society of Anesthesiologists Research Committee
2019-2021
Invited Grant Reviewer Society of Cardiovascular Anesthesiologists Grant Review Committee member
Organization:
Society of Cardiovascular Anesthesiologists (SCA) Research Committee
2021
Invited Grant Reviewer
Organization:
Australian and New Zealand College of Anaesthetists’ 2022 Research Grants
2016
Invited Grant Reviewer
Organization:
Texas Regional CTSA Consortium (TRCC) Clinical Trials Pilot Grant Program
Grant Support
Present
2019-2024
Grantor: NIH NHLBI R01HL148448
Title of Project: Blood and Urine Biomarkers for Predicting Long-Term Adverse Kidney and Cardiovascular Outcomes after Cardiac Surgery
Role: Principal Investigator
Total amount of award: Provides $3,679,471.00 in total direct and indirect costs to support biomarker assays, equipment, research personnel, statistical personnel, and institutional overhead.
Past
2016-2019
Grantor: O’Brien Kidney Center Pilot and Feasibility Grant, University of Texas Southwestern Medical Center
Title of Project: Klotho: Biomarker of Early Onset of Acute Kidney Injury after Cardiac Surgery
Role: Principal Investigator of Pilot and Feasibility Grant. Dr. Orson Moe is PI of UT Southwestern’s overall NIH P30DK079328 award.
Total amount of award: Provides $35,000 to support salary of principal investigator, Klotho assays, and research assistant time.
2015-2017
Grantor: NIH NIDDK Revision R01 DK092461
Title of Project: Klotho: Therapeutic Agent for Ischemia Reperfusion Induced Acute Kidney Injury
Role: Co-Investigator; Principal Investigator Dr. Ming-Chang Hu
Total amount of award: Provided $75,000 to support salaries of investigators and research staff to measure Klotho assays in biobanked human serum stored from cardiac surgical cohorts.
2012-2015
Grantor: Society of Cardiovascular Anesthesiologists/ International Anesthesia Research Society Mid-Career Research Grant
Title of Project: Genome-Wide Assessment of Genetic Associations with Heart Failure after Primary Coronary Artery Bypass Graft Surgery
Role: Principal Investigator
Total amount of award: Provided $100,000 to support costs of the project and principal investigator’s salary. This study is investigating the association between allotypic variation within the whole genome and development of long-term heart failure after primary coronary artery bypass graft surgery.
2012-2013
Grantor: Harvard Medical Scholars Program Eleanor and Miles Shore Career Development Award
Title of Project: Genome-Wide Assessment of Genetic Associations with Heart Failure after Primary Coronary Artery Bypass Graft Surgery
Role: Principal Investigator
Total amount of award: This award provides $30,000 to support research personnel needed to investigate the association between allotypic variation within the whole genome and development of long-term heart failure after primary coronary artery bypass graft surgery.
2009-2012
Grantor: American Geriatrics Society, Jahnigen Career Development Award
Title of Project: Influence of In-Hospital Ventricular Dysfunction and Related Genetic Variants on the Development of Long-Term Heart Failure and Quality of Life Outcomes in Older Patients after Primary Coronary Artery Bypass Graft Surgery
Role: Principal Investigator
Total amount of award: Provided $150,000 to support the costs of the project and principal investigator’s salary. This study investigated genetic, biomarker and clinical predicators of long-term physical function and heart failure in the elderly after primary coronary artery bypass graft surgery.
2007-2009
Grantor: Foundation Anesthesia Education Research, Research Starter Grant
Title of Project: Genotypic Influences on Postoperative B-Type Natriuretic Peptide Concentrations and Ventricular Dysfunction with Coronary Artery Bypass Graft Surgery
Role: Principal Investigator
Total amount of award: Provided $35,000 for the first year and $50,000 for the second year to support project costs and principal investigator’s salary. This study investigated the association between allotypic variation within the whole genome and occurrence of in-hospital postoperative ventricular dysfunction following primary coronary artery bypass graft surgery.
2007-2008
Grantor: Harvard Medical Scholars Program Eleanor and Miles Shore Career Development Fellowship
Title of Project: Influence of Natriuretic Peptide Genes on Cardiovascular Outcomes after Primary Coronary Artery Bypass Graft Surgery
Role: Principal Investigator
Total amount of award: This fellowship provided $20,000 to investigate the association between genetic variation within 7 candidate genes related to the natriuretic peptide system and both perioperative plasma B-type natriuretic peptide concentrations and postoperative ventricular dysfunction in >1100 patients undergoing primary coronary artery bypass graft surgery with cardiopulmonary bypass.
2005-2007
Grantor: Simon Gelman Career Development Fellowship for Faculty Research Brigham and Women’s Hospital, Department of Anesthesiology, Perioperative and Pain Medicine
Title of Project: Genotypic and Phenotypic Influences of Brain Natriuretic Peptide on Adverse Cardiac Outcomes after Coronary Artery Bypass Graft Surgery
Role: Principal Investigator
Total amount of award: Departmental research support awarded biannually to a faculty member with promising research potential. This fellowship provided salary to support 40% nonclinical time to pursue the Society of Cardiovascular Research Starter Grant’s study of the relationship between elevated plasma B-type natriuretic peptide concentrations and outcomes after coronary artery bypass surgery.
2005-2007
Grantor: Society of Cardiovascular Anesthesiologists Research Starter Grant
Title of Project: Genotypic and Phenotypic Influences of Brain Natriuretic Peptide on Adverse Cardiac Outcomes after Coronary Artery Bypass Graft Surgery
Role: Principal Investigator
Total amount of award: This grant provided $20,000 per year for two years for laboratory, technician, and statistical support to investigate whether 1) variations within the natriuretic peptide precursor A and B genes (NPPA and NPPB) and 2) elevations in perioperative plasma B-type natriuretic peptide (BNP) concentrations associated with in-hospital postoperative ventricular dysfunction in >1100 patients undergoing primary coronary artery bypass graft surgery, 2005-2007.
2004-2005
Grantor: General Clinical Research Grant NCRR M01 02558
Title of Project: Genotypic and Phenotypic Influences of Brain Natriuretic Peptide on Adverse Perioperative Outcomes Following Coronary Artery Bypass Graft Surgery
Role: Co-Principal Investigator
Total amount of award: Provided $10,000 worth of serum B-type natriuretic peptide concentrations for a pilot study