The Burgess lab uses Nuclear Magnetic Resonance spectroscopy and Mass Spectrometry in conjunction with stable isotope (non-radioactive) tracers to study how metabolic flux is altered by disease, pharmacology, or targeted genetic interventions.
We focus on pathways of oxidative and biosynthetic metabolism in the context of obesity, insulin resistance, and diabetes. The technologies and metabolic insight from dietary and/or genetic interventions in mice are routinely translated to investigations in human subjects with the goal of understanding the molecular and metabolic basis of human disease.