Phase II Trial of Sipuleucel-T and Stereotactic Ablative Body Radiation for Patients with Metastatic Castrate-Resistant Prostate Cancer
Hannan R, Dohopolski MJ, Pop LM, Mannala S, Watumull L, Mathews D, Gao A, Garant A, Arriaga YE, Bowman I, Chung J-S, Wang J, Ariizumi K, Ahn C, Timmerman R, Courtney K. Phase II Trial of Sipuleucel-T and Stereotactic Ablative Body Radiation for Patients with Metastatic Castrate-Resistant Prostate Cancer. Biomedicines, 2022 Jun 15;10(6):1419. doi: 10.3390/biomedicines10061419.
Soluble DC-HIL/Gpnmb Modulates T-lymphocyte Extravasation to Inflamed Skin
Ramani V, Chung J-S, Ariizumi K,* and Cruz PD Jr. Soluble DC-HIL/Gpnmb Modulates T-lymphocyte Extravasation to Inflamed Skin. *Corresponding author. J. Invest Dermatol, 142(5):1372-1380. 2022. PMID: 34695414
DC-HIL/Gpnmb is a negative regulator of tumor response to immune checkpoint inhibitors
Chung J-S, Ramani V, Kobayashi M, Fattah F, Popat V, Zhang S, Cruz PD Jr., Gerber DE, Ariizumi K. DC-HIL/Gpnmb is a negative regulator of tumor response to immune checkpoint inhibitors. Clin Cancer Res 15; 1449-1459. 2020. PMID: 31822499
NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation
Brosseau JP, Liao CP, Wang Y, Ramani V, Vandergriff T, Lee M, Patel A, Ariizumi K, Le LQ. NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation. Nat Commun. 2019. 27; 9:5014. PMID: 30479396.
Expansion of myeloid-derived suppressor cells in the peripheral blood and lesional skin of cutaneous lupus patients
Florez-Pollack S, Tseng L, Kobayashi M, Hosler GA, Ariizumi K, Chong BF. Expansion of myeloid-derived suppressor cells in the peripheral blood and lesional skin of cutaneous lupus patients. J. Invest. Dermatol. 2019 139:478-481. PMID: 30300609.
Blocking monocytic myeloid-derived suppressor cell function via anti-DC-HIL/GPNMB antibody restores the in vitro integrity of T-cells from cancer patients
Kobayashi M, Chung J-S, Beg M, Arriaga Y, Verma U, Courtney K, Mansour JC, Haley B, Khan SA, Horiuchi Y, Ramani V, Harker D, Gopal P, Araghizadeh F, Cruz PD Jr., Ariizumi K. Blocking monocytic myeloid-derived suppressor cell function via anti-DC-HIL/GPNMB antibody restores the in vitro integrity of T-cells from cancer patients. Clin Cancer Res. 2019. 25:828-838. PMID: 30049749.
Melanoma-derived Soluble DC-HIL/GPNMB Promotes Metastasis by Excluding T-lymphocytes from the Pre-metastatic Niches
Ramani V, Teshima T, Tamura K, Chung J-S, Kobayashi M, Cruz PD Jr, Ariizumi K. Melanoma-derived Soluble DC-HIL/GPNMB Promotes Metastasis by Excluding T-lymphocytes from the Pre-metastatic Niches. J. Invest. Dermatol. 2018. 138:2443-2451. PMID: 29857071.
Myeloid-derived suppressor cells in psoriasis are an expanded population exhibiting diverse T cell-suppressor mechanisms
Cao LY, Chung J-S, Teshima T, Feigenbaum L, Cruz PD Jr, Jacobe HT, Chong BF, Ariizumi K. Myeloid-derived suppressor cells in psoriasis are an expanded population exhibiting diverse T cell-suppressor mechanisms. J. Invest. Dermatol. 2016. 136:1801-1810. PMID: 27236103.
DC-HIL+ CD14+ HLA-DRno/low cells are a potential blood marker and therapeutic target for melanoma
Turrentine J, Chung J-S, Nezafati K, Tamura K, Harker-Murray A, Huth J, Sharma RR, Harker DB, Ariizumi K,* Cruz PD Jr.* DC-HIL+ CD14+ HLA-DRno/low cells are a potential blood marker and therapeutic target for melanoma. *Equally contributed as last author. J. Invest. Dermatol. 2014. 134:2839-2842. PMID: 2493332
DC-HIL-expressing myelomonocytic cells are critical promoters of melanoma growth
Chung J-S, Tamura K, Cruz PD Jr, Ariizumi K. DC-HIL-expressing myelomonocytic cells are critical promoters of melanoma growth. J. Invest. Dermatol. 2014. 134:2784-2794. PMID: 24936834
DC-HIL/Syndecan-4 pathway regulates autoimmunity through myeloid-derived suppressor cells
Chung J-S, Tamura K, Akiyoshi H, Cruz PD Jr, Ariizumi K. DC-HIL/Syndecan-4 pathway regulates autoimmunity through myeloid-derived suppressor cells. J Immunol. 192:2576-2584, 2014. PMCID: PMC3957202; PMID: 24516197.
The DC-HIL ligand syndecan-4 is a negative regulator of T cell alloreactivity responsible for graft-versus-host disease
Chung J-S, Tomihari K, Tamura K, Kojima T, Cruz PD Jr, Ariizumi K. The DC-HIL ligand syndecan-4 is a negative regulator of T cell alloreactivity responsible for graft-versus-host disease. Immunology 138:173-182, 2013.
Inhibition of T-cell activation by syndecan-4 is mediated by CD148 through protein tyrosine phosphatase activity
Chung J-S, Cruz PD Jr, Ariizumi K. Inhibition of T-cell activation by syndecan-4 is mediated by CD148 through protein tyrosine phosphatase activity. Eur. J. Immunol. 41:1794–1799, 2011.
Sezary syndrome cells overexpress syndecan-4 bearing distinct heparan sulfate moieties that suppress T cell activation by binding DC-HIL and trapping TGF-b on the cell
Chung J-S, Shiue LH, Duvic M, Pandya A, Cruz PD Jr, Ariizumi K. Sezary syndrome cells overexpress syndecan-4 bearing distinct heparan sulfate moieties that suppress T cell activation by binding DC-HIL and trapping TGF-b on the cell. Blood 117:3382-3390, 2011.
CARD9 mediates Dectin-2-induced IKK ubiquitination leading to activation of NF-kappaB in response to the stimulation by the hyphal form of Candida albicans
Bi L, Gorjestani S, Wu W, Hsu YM, Zhu J, Ariizumi K, Lin X. CARD9 mediates Dectin-2-induced IKK ubiquitination leading to activation of NF-kappaB in response to the stimulation by the hyphal form of Candida albicans. J Biol Chem. 285:25969-25977, 2010.
DC-HIL/Gpnmb promotes growth of melanoma in mice by inhibiting activation of tumor-reactive T cells
Tomihari M, Chung J-S, Akiyoshi H, Cruz PD Jr, Ariizumi K. DC-HIL/Gpnmb promotes growth of melanoma in mice by inhibiting activation of tumor-reactive T cells. Cancer Res 70:5778-5787, 2010.
Depleting syndecan-4+ T lymphocytes using toxin-bearing DC-HIL: A new opportunity for treating activated T cell-driven disease
Akiyoshi H, Chung J-S, Tomihari M, Cruz PD Jr, Ariizumi K. Depleting syndecan-4+ T lymphocytes using toxin-bearing DC-HIL: A new opportunity for treating activated T cell-driven disease. J. Immunol. 184: 3554 -3561, 2010.
Binding of DC-HIL to dermatophytic fungi Induces tyrosine phosphorylation and potentiates antigen presenting cell function
Chung J-S, Yudate T, Tomihari M, Akiyoshi H, Cruz PD Jr, Ariizumi K. Binding of DC-HIL to dermatophytic fungi Induces tyrosine phosphorylation and potentiates antigen presenting cell function. J. Immunol. 183:5190-5198, 2009.
The DC-HIL/syndecan-4 pathway inhibits human allogeneic T cell responses
Chung J-S, Bonkobara M, Tomihari M, Cruz PD Jr., Ariizumi K. The DC-HIL/syndecan-4 pathway inhibits human allogeneic T cell responses. Eur. J. Immunol. 39: 965–974, 2009.
Syndecan-4 mediates the co-inhibitory function of DC-HIL on T cell activation
Chung J-S, Dougherty I, Cruz PD Jr, Ariizumi K. Syndecan-4 mediates the co-inhibitory function of DC-HIL on T cell activation. J. Immunol. 179:5778-84, 2007.
DC-HIL is a negative regulator of T cell activation
Chung J-S, Sato K, Dougherty I, Cruz PD Jr, Ariizumi K. DC-HIL is a negative regulator of T cell activation. Blood 109:4320-4327, 2007.
Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor g chain to induce innate immune responses
Sato K, Yang X-L, Yudate T, Chung J-S, Wu J, Luby-Phelps K, Kimberly RP, Underhill D, Cruz PD Jr., and Ariizumi K. Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor g chain to induce innate immune responses. J. Biol. Chem. 281:38854-38866, 2006.
Selective expression of vacuolar H+-ATPase subunit d2 by particular subsets of dendritc cells among leukocytes
Sato K, Shikano S, Xia G, Takao J, Cruz PD Jr, Xie X-S, Ariizumi K. Selective expression of vacuolar H+-ATPase subunit d2 by particular subsets of dendritc cells among leukocytes. Mol. Immunol. 43:1443-1453, 2006.
Identification and expression profiling of a human C-type lectin structurally homologous to mouse dectin-2
Gavino AC, Chung J-S, Sato K, Ariizumi K, Cruz PD Jr: Identification and expression profiling of a human C-type lectin structurally homologous to mouse dectin-2. Exp Dermatol 14: 281-288. 2005.
Keptin is a secreted protein expressed selectively by granular keratinocytes
Tsuchida S, Bonkobara M, McMillan JR, Akiyama M, Yudate T, Aragane Y, Tezuka T, Shimizu H, Cruz PDJr, and Ariizumi K: Keptin is a secreted protein expressed selectively by granular keratinocytes. J. Invest. Dermatol. 122: 1225-1234, 2004.
Involvement of dectin-2 in ultraviolet radiation-induced tolerance
Aragane Y, Maeda A, Schwarz A, Tezuka T, Ariizumi K, Schwarz T: Involvement of dectin-2 in ultraviolet radiation-induced tolerance. J. Immunol. 171: 3801-3807, 2003.
Expression of NF-kB in epidermis and the relationship between NF-kB activation and inhibition of keratinocyte growth
Takao J, Ariizumi K, Cruz PDJr.: Expression of NF-kB in epidermis and the relationship between NF-kB activation and inhibition of keratinocyte growth. British J. Dermatol, 148: 680-688, 2003.
Epidermal Langerhans cell-targeted gene expression by a dectin-2 promote
Bonkobara M. Zukas PK, Shikano S, Nakamura I, Cruz PDJr, Ariizumi K: Epidermal Langerhans cell-targeted gene expression by a dectin-2 promoter. J. Immunol. 167:6893- 6900, 2001.
Molecular Cloning of a Dendritic Cell-Associated Transmembrane Protein, DC-HIL, that Promotes RGD-Dependent Adhesion of Endothelial Cells Through Recognition of Heparan Sulfate Proteoglycans
Shikano S, Bonkobara M, Zukas P, Ariizumi K: Molecular Cloning of a Dendritic Cell-Associated Transmembrane Protein, DC-HIL, that Promotes RGD-Dependent Adhesion of Endothelial Cells Through Recognition of Heparan Sulfate Proteoglycans. J. Biol. Chem. 276:8125-8135, 2001.
Identification of a novel, dendritic cell-associated C-type lectin (Dectin-1) by subtractive cDNA cloning
Ariizumi K, Shen, G-L, Shikano S, Xu S, Ritter RIII, Edelbaum D, Morita A. Bergstresser PR, Takashima A: Identification of a novel, dendritic cell-associated C-type lectin (Dectin-1) by subtractive cDNA cloning. J. Biol. Chem. 275: 20157-20167, 2000. PMID: 10779524.
Cloning of a second dendritic Cell-associated C-type lectin (Dectin-2) and its alternatively spliced isoforms
Ariizumi K, Shen, G-L, Shikano S, Ritter RIII, Zukas P, Edelbaum D. Morita A. Takashima A: Cloning of a second dendritic Cell-associated C-type lectin (Dectin-2) and its alternatively spliced isoforms. J. Biol. Chem. 275: 11957-11963, 2000.