Publications

The fantastic gibberish and where to find it

  1. Identification of TRAMs as Sphingolipid-Binding Proteins Using a Photoactivatable and Clickable Short Chain Ceramide Analog
    Deng, Y.; You, L.; Lu, Y.; Han, S.; Wang, J.; Vicas, N.; Chen, C.; Ye, J.
    J. Biol. Chem. 2021, 297,101415 (PMID: 34793833)

  2. Avoid the Trap: Targeting PARP1 Beyond Human Malignancy
    Kim, C.; Chen, C.; Yu, Y.
    Cell Chem. Biol. 2021, 28, 456–462 (PMID: 33657415)

  3. Novel Necroptosis-blocking Compound NBC1 Targets Heat Shock Protein 70 to Inhibit MLKL Polymerization and Necroptosis
    Johnston, A.; Ma, Y.; Liu, H.; Liu, S.; Hanna-Addams, S.; Chen, S.; Chen, C.; Wang, Z.
    Proc. Natl. Acad. Sci. 2020, 117, 6521–6530 (PMID: 32156734)

  4. Uncoupling of PARP1 Trapping and Inhibition Using Selective PARP1 Degradation
    Wang, S.; Han, L.; Han, J.; Li, P.; Ding, Q.; Zhang, Q.-J.; Liu, Z.-P.; Chen, C,; Yu, Y.
    Nat. Chem. Biol. 2019, 15, 1223-1231 (PMID: 31659317)

  5. Stereoselective Fatty Acylation Is Essential for the Release of Lipidated WNT Proteins from the Acyltransferase Porcupine (PORCN)
    Tuladhar, R.; Yarravarapu, N.; Ma, Y.; Zhang, C.; Herbert, J.; Kim, J.; Chen, C.; Lum, L.
    J. Biol. Chem. 2019, 294, 6273–6282 (PMID: 30737280)

  6. Installation of a Cancer Promoting WNT/SIX1 Signaling Axis by the Oncofusion Protein MLL-AF9
    Zhang, L.-s.; Kang, X.; Lu, J.; Zhang, Y.; Wu, X.; Wu, G.; Zheng, J.; Tuladhar, R.; Shi, H.; Wang, Q.; Morlock, L.; Yao, H.; Huang, L. J.-s.; Maire, P.; Kim, J.; Williams, N.; Xu, J.; Chen, C.; Zhang, C. C.; Lum, L.
    EBioMedicine 2019, 39, 145–158 (PMID: 30528456)

  7. Rapid Access to the Core Skeleton of the [3 + 2]-Type Dimeric Pyrrole–Imidazole Alkaloids by Triplet Ketone-Mediated C–H Functionalization (Invited Article for Tetrahedron Symposium-in-Print “Biogenetic Considerations in Complex Synthesis”)
    You, L.; Chen, C.
    Tetrahedron 2018, 74, 769–772 (PMID: 29622843)

  8. Natural Products as Inspiration for the Development of New Synthetic Methods (Invited Article in honor of Prof. Tien-Yau Luh’s 70th Birthday)
    Ma, Z.; Chen, C.
    J. Chin. Chem. Soc. 2018, 1, 43–59 (PMID: 29430058)

  9. A Synthetic Combinatorial Approach to Disabling Deviant Hedgehog Signaling
    Fan, C. W.; Yarravarapu, N.; Shi, H.; Kulak, O.; Kim, J.; Chen, C.; Lum, L.
    Sci. Rep. 2018, 8, 1133 (PMID: 29348431)

  10. Ketone-Catalyzed Photochemical C(sp3)–H Chlorination (Invited Article in honor of Prof. Ang Li’s 2017 Tetrahedron Young Investigator Award)
    Han, L.; Xia, J.-B.; You, L.; Chen, C.
    Tetrahedron 2017, 73, 3696–3701 (PMID: 28717256)

  11. cGAS Is Essential for the Antitumor Effect of Immune Checkpoint Blockade
    Wang, H.; Hu, S.; Chen, X.; Shi, H.; Chen, C.; Sun, Li; Chen, Z. J.
    Proc. Natl. Acad. Sci. 2017, 114, 1637–1642 (PMID: 28137885)

  12. Stereocontrolled Formation of a [4.4]Heterospiro Ring System with Unexpected Inversion of Configuration at the Spirocenter
    Ma, Z.; You, L.; Chen, C.
    J. Org. Chem. 2017, 82, 731–736 (PMID: 27933858)

  13. Development of a Triazole Class of Highly Potent Porcn Inhibitors
    You, L.; Zhang, C.; Yarravarapu, N.; Morlock, L.; Wang, X.-L.; Zhang, L.; Williams, N. S.; Lum, L.; Chen, C.
    Bioorg. Med. Chem. Lett. 2016, 26, 5891–5895 (PMID: 27876319)

  14. Palladium-Catalyzed C–H Arylation of 1,2,3-Triazoles (Invited Article for the Reactions of Hydrocarbons and other C-H Compounds Special Issue)
    Zhang, C.; You, L.; Chen, C.
    Molecules 2016, 20, 1268 (PMID: 27669198)

  15. The past, present, and future of the Yang Reaction (Invited Review Article)
    Chen, C.
    Org. Biomol. Chem. 2016, 14, 8641–8647 (PMID: 27517138)

  16. Asymmetric Synthesis of Axinellamines A and B
    Ma, Z.; Wang, X.; Ma, Y.; Chen, C.
    Angew. Chem. Int. Ed. 2016, 55, 4763–4766 (PMID: 27037993) (Synfacts highlight)

  17. Chemical Disruption of Wnt-Dependent Cell Fate Decision-Making Mechanisms in Cancer and Regenerative Medicine (Invited Review Article)
    Lum, L.; Chen, C.
    Curr. Med. Chem. 2015, 22, 4091–4103 (PMID: 26310918)

  18. Identification and Characterization of β-Sitosterol Target Proteins (Invited Article for the 25th Anniversary Symposium-in-Print “Recent Advances in Medicinal Chemistry and Chemical Biology”)
    Lomenick, B.; Shi, H.; Huang, J.; Chen, C.
    Bioorg. Med. Chem. Lett. 2015, 25, 4976–4979 (PMID: 25804720)

  19. 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling
    Fu, X.; Chin, R. M.; Vergnes, L.; Hwang, H.; Deng, G.; Xing, Y.; Pai, M. Y.; Li, S.; Ta, L.; Fazlollahi, F.; Chen, C.; Prins, R. M.; Teitell, M. A.; Nathanson, D. A.; Lai, A.; Faull, K. F.; Jiang, M.; Clarke, S. G.; Cloughesy, T. F.; Graeber, T. G.; Braas, D.; Christofk, H. R.; Jung, M. E.; Reue, K.; Huang J.
    Cell Metab. 2015, 22, 508–515 (PMID: 26190651)

  20. Molecular Basis for the Specific Recognition of the Metazoan Cyclic GMP-AMP by the Innate Immune Adaptor Protein STING
    Shi, H.; Wu, J.; Chen, Z. J.; Chen, C.
    Proc. Natl. Acad. Sci. 2015, 112, 8947–8952 (PMID: 26150511)

  21. Syntheses of Sceptrins and Nakamuric Acid and Insights into the Biosyntheses of Pyrrole–Imidazole Dimers
    Wang, X.-L.; Gao, Y.; Ma, Z.; Rodriguez, R. A.; Yu, Z.-X.; Chen, C.
    Org. Chem. Front. 2015, 2, 978–984 (PMID: 26328059)

  22. Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells
    Kulak, O.; Chen, H.; Holohan, B.; Wu, X.; He, H.; Borek, D.; Otwinowski, Z.; Yamaguchi, K.; Garofalo, L. A.; Ma, Z.; Wright, W.; Chen, C.; Shay, J. W.; Zhang, X.; Lum, L.
    Mol. Cell Biol. 2015, 35, 2425–2435 (PMID: 25939383)

  23. Construction of the 5,6,7-tricyclic skeleton of lancifodilactone F (Invited Article for Tetrahedron Letters Symposium-in-Print in Memory of Prof. Harry Wasserman)
    Shi, H.; De, S.; Wang, Q.; Gao, S.; Wang, X.; Chen, C.
    Tetrahedron Lett. 2015, 56, 3225–3227 (PMID: 26097263)

  24. An Approach for the Synthesis of Nakamuric Acid (Invited Article for Tetrahedron Symposium-in-Print “Synthesis of Indole/Pyrrole-Containing Natural Products”)
    Wang, X.-L.; Chen, C.
    Tetrahedron, 2015, 71, 3690–3693 (PMID: 25983349)

  25. Syntheses of Cyclic Guanidine-Containing Natural Products (Invited Review Article)
    Ma, Y.; De, S.; Chen, C.
    Tetrahedron 2015, 71, 1145–1173 (PMID: 25684829)

  26. The Hedgehog Pathway Effector Smoothened Exhibits Signaling Competency in the Absence of Ciliary Accumulation
    Fan, C.-W.; Chen, B.; Franco, I.; Lu, J.; Shi, H.; Wei, S.; Wang, C.; Wu, X.; Tang, W.; Roth, M. G.; Williams, N. S.; Hirsch, E.; Chen, C.; Lum, L.
    Chem. Biol. 2014, 21, 1680–1689 (PMID: 25484239)

  27. Asymmetric Syntheses of Sceptrin and Massadine and Evidence for Biosynthetic Enantiodivergence
    Ma, Z.; Wang, X.-L.; Wang, X.; Rodriguez, R. A.; Moore, C. E.; Gao, S.; Tan, X.; Ma, Y.; Rheingold, A. L.; Baran, P. S.; Chen, C.
    Science 2014, 346, 219–224 (PMID: 25301624) (response to comment)

  28. Visible Light-Promoted Metal-Free sp3-C–H Fluorination
    Xia, J.-B.; Zhu, C.; Chen, C.
    Chem. Commun. 2014, 50, 11701–11704 (PMID: 25143256)

  29. Dimeric Pyrrole–Imidazole Alkaloids: Synthetic Approaches and Biosynthetic Hypotheses (Invited Review Article)
    Wang, X.; Ma, Z.; Wang, X.-L.; De, S.; Ma, Y.; Chen, C.
    Chem. Commun. 2014, 50, 8628–8639 (PMID: 24828265)

  30. Vanadium-Catalyzed C(sp3)–H Fluorination Reactions
    Xia, J.-B.; Ma, Y.; Chen, C.
    Org. Chem. Front. 2014, 1, 468–472 (P)MID: 24976971)

  31. A Simple Method for the Electrophilic Cyanation of Secondary Amines
    Zhu, C.; Xia, J.-B.; Chen, C.
    Org. Lett. 2014, 16, 247–250 (PMID: 24313859)

  32. Vanadium-Catalyzed Oxidative Strecker Reaction: α-C–H Cyanation of para-Methoxyphenyl (PMP)-Protected Primary Amines
    Zhu, C.; Xia, J.-B.; Chen, C.
    Tetrahedron Lett. 2014, 55, 232–234 (PMID: 24415804)

  33. Visible Light-Promoted Metal-Free C–H Activation: Diarylketone-Catalyzed Selective Benzylic Mono- and Difluorination
    Xia, J.-B.; Zhu, C.; Chen, C.
    J. Am. Chem. Soc. 2013, 135, 17494–17500 (PMID: 24180320) (Synfacts highlight)

  34. Stromal-Epithelial Crosstalk Regulates Kidney Progenitor Cell Differentiation
    Das, A.; Tanigawa, S.; Karner, C. M.; Xin, M.; Lum, L.; Chen, C.; Olson, E. N.; Perantoni, A. O.; Carroll, T. J.
    Nat. Cell Biol. 2013, 15, 1035–1044 (PMID: 23974041)

  35. Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High Affinity Ligand for STING
    Zhang, X.; Shi, H.; Wu, J.; Zhang, X.; Sun, L.; Chen, C.; Chen, Z. J.
    Mol. Cell 2013, 51, 226–235 (PMID: 23747010)

  36. The Development of Highly Potent Inhibitors for Porcupine
    Wang, X.-L.; Moon, J.; Dodge, M. E.; Pan, X.; Zhang, L.; Hanson, J.; Tuladhar, R.; Ma, Z.; Shi, H.; Williams, N. S.; Amatruda, J.; Carroll, T. J.; Lum, L.; Chen, C.
    J. Med. Chem. 2013, 56, 2700–2704 (PMID: 23477365)

  37. Cyclic-GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
    Wu, J.; Sun, L.; Chen, X.; Du, F.; Shi, H.; Chen, C.; Chen, Z. J.
    Science 2013, 339, 826–830 (PMID: 23258412) (Perspective)

  38. Nakiterpiosin (Invited Book Chapter)
    Gao, S.; Chen. C.
    In Total Synthesis of Natural Products–At the Frontiers of Organic Chemistry; Li, J. J., Corey, E. J., Eds.; Springer-Verlag: Berlin/Heidelberg, 2013; pp 25–38

  39. A Biomimetic Route for the Construction of the [4+2] and [3+2] Core Skeletons of the Dimeric Pyrrole–Imidazole Alkaloids and the Asymmetric Synthesis of Ageliferins
    Wang, X.; Wang, X.-L.; Tan, X.; Lu, J.; Cormier, K. W.; Ma, Z.; Chen. C.
    J. Am. Chem. Soc. 2012, 134, 18834–18842 (PMID: 23072663) (correction1) (correction2)

  40. The Chemistry and Biology of Nakiterpiosin (Invited Review Article)
    Gao, S.; Wang, Q.; Wang, G.; Lomenick, B; Liu, J.; Fan, C.-W.; Deng, L.-W.; Huang, J.; Lum, L.; Chen. C.
    Synlett 2012, 23, 2298–2310 (PMID: 23226922)

  41. A Highly Selective Vanadium Catalyst for Benzylic C–H Oxidation
    Xia, J.; Cormier, K. W.; Chen, C.
    Chem. Sci. 2012, 3, 2240–2245 (PMID: 22712051)

  42. Diverse Chemical Scaffolds Support Direct Inhibition of the Membrane Bound O-Acyltransferase Porcupine
    Dodge, M. E.; Moon, J.; Tuladhar, R.; Lu, J.; Jacob, L. S.; Zhang, L.-s.; Shi, H.; Wang, X.-L.; Moro, E.; Mongera, A.; Argenton, F.; Karner, C. M.; Carroll, T. J.; Chen, C.; Amatruda, J. F.; Lum, L.
    J. Biol. Chem. 2012, 287, 23246–23254 (PMID: 22593577)

  43. In Vivo Wnt Signaling Tracing through a Transgenic Biosensor Fish Reveals Novel Activity Domains
    Moro, E.; Ozhan-Kizil, G.; Mongera, A.; Beis, D.; Wierzbicki, C.; Young, R. M.; Bournele, D.; Domenichini, A.; Valdivia, L. E.; Lum, L.; Chen, C.; Amatruda, J. F.; Tiso, N.; Weidinger, G.; Argenton, F.
    Dev. Biol. 2012, 366, 327–340 (PMID: 22546689)

  44. Asymmetric Synthesis of Ageliferin
    Wang, X.; Ma, Z.; Lu, J.; Tan, X.; Chen, C.
    J. Am. Chem. Soc. 2011, 133, 15350–15353 (PMID: 21888421) (correction)

  45. Canonical Wnt9b Signaling Balances Progenitor Cell Expansion and Differentiation During Kidney Development
    Karner, C. M.; Das, A.; Ma, Z.; Self, M.; Chen, C.; Lum, L.; Oliver, G.; Carroll T. J.
    Development 2011, 138, 1247–1257 (PMID: 21350016)

  46. Revisiting the Kinnel–Scheuer Hypothesis for the Biosynthesis of Palau’amine (Invited Article for the Emerging Investigator Special Issue)
    Ma, Z.; Lu, J.; Wang, X.; Chen, C.
    Chem. Commun. 2011, 47, 427–429 (PMID: 20848010)

  47. Tankyrase Is Necessary for Canonical Wnt Signaling during Kidney Development
    Karner, C. M.; Michael Dodge, C. E.; Ma, Z.; Lu, J.; Chen, C.; Lum, L.; Carroll, T. J.
    Dev. Dyn. 2010, 239, 2014–2023 (PMID: 20549720)

  48. Chemical and Biological Studies of Nakiterpiosin and Nakiterpiosinone
    Gao, S.; Wang, Q.; Huang, L. J.; Lum, L.; Chen, C.
    J. Am. Chem. Soc. 2010, 132, 371–383 (PMID: 20000429)

  49. Structure/Activity Relationship Studies of Small-Molecule Inhibitors of Wnt Response (Invited Article in honor of Prof. Carlos Barbas III’s 2009 Tetrahedron Young Investigator Award in Bioorganic and Medicinal Chemistry)
    Lu, J.; Ma, Z.; Hsieh, J.-C.; Fan, C.-W.; Chen, B.; Longgood, J. C.; Williams, N. S.; Amatruda, J. F.; Lum, L.; Chen, C.
    Bioorg. Med. Chem. Lett. 2009, 19, 3825–3827 (PMID: 19410457)

  50. Synthesis and Structure Revision of Nakiterpiosin
    Gao, S.; Wang, Q.; Chen, C.
    J. Am. Chem. Soc. 2009, 131, 1410–1412 (PMID: 18998640) (cover picture) (Synfacts highlight)

  51. Small Molecule-mediated Disruption of Wnt-dependent Signal Transduction in Tissue Regeneration and Cancer
    Chen, B.; Dodge, M. E.; Tang, W.; Lu, J.; Ma, Z.; Fan, C.-W.; Wei, S.; Hao, W.; Kilgore, J. A.; Williams, N. S.; Roth, M. G.; Amatruda, J. F.; Chen, C.; Lum, L.
    Nat. Chem. Biol. 2009, 5, 100–107 (PMID: 19125156) (News and Views)

  52. On the Potent Inhibitors of the Hedgehog Signaling Pathway (Invited Condensation and Commentary)
    Chen, C.
    Chemtracts–Org. Chem. 2008, 21, 150–154

  53. Nickel-Catalyzed Carbonylative Negishi Cross-Coupling Reactions
    Wang, Q.; Chen, C.
    Tetrahedron Lett. 2008, 49, 2916–2921 (Synfacts highlight)

  54. An Approach to the Core Skeleton of Lancifodilactone F
    Wang, Q.; Chen, C.
    Org. Lett. 2008, 10, 1223–1226 (PMID: 18303901)

  55. Palladium-Catalyzed Direct Functionalization of Imidazolinone: Synthesis of Dibromophakellstatin
    Lu, J.; Tan, X.; Chen, C.
    J. Am. Chem. Soc. 2007, 129, 7768–7769 (PMID: 17539649) (Addition)

  56. Regiocontrol in Manganese(III)-Mediated Oxidative Heterobicyclizations: Access to the Core Skeletons of roidin Dimers
    Tan, X.; Chen, C.
    Angew. Chem. Int. Ed. 2006, 45, 4345–4348 (PMID: 16739146)
  57. Convergent Diversity-Oriented Synthesis of Small-Molecule Hybrids
    Chen, C.; Li, X.; Neumann, C. S.; Lo, M. M.-C.; Schreiber, S. L.
    Angew. Chem. Int. Ed. 2005, 44, 2249–2252 (PMID: 15747386)
  58. Label-free Detection of Small-molecule–Protein Interactions by Using Nanosensors
    Wang, W. U.; Chen, C.; Lin, K.-h.; Fang, Y.; Lieber, C. M.
    Proc. Natl. Acad. Sci. 2005, 102, 3208–3212 (PMID: 15716362)
  59. Catalytic Asymmetric [3+2] Cycloaddition of Azomethine Ylides. Development of a Versatile Stepwise, Three-Component Reaction for Diversity-Oriented Synthesis
    Chen, C.; Li, X.; Schreiber, S. L.
    J. Am. Chem. Soc. 2003, 125, 10174–10175 (PMID: 12926931)

  60. Abnormal and Regioselective Wacker Oxidation of 1,5-Diene
    Ho, T.-L.; Chang, M.; Chen, C.
    Tetrahedron Lett. 2003, 44, 6955–6957
  61. Synthesis of (+)-CP-263,114
    Chen, C.; Layton, M. E.; Sheehan, S. M.; Shair, M. D.
    J. Am. Chem. Soc. 2000, 122, 7424–7425
  62. Chelation-Assisted Regioselective C–O Bond Cleavage Reactions of Acetals by Grignard Reagents. A General Procedure for the Regioselective Synthesis of Protected Polyols Having One Free Hydroxy Group
    Cheng, W.-L.; Shaw, Y.-J.; Yeh, S.-M.; Kanakamma, P. P.; Chen, Y.-H.; Chen, C.; Shieu, J.-C.; Yiin, S.-J.; Lee, G.-H.; Wang, Y.; Luh, T.-Y.
    J. Org. Chem. 1999, 64, 532–539
  63. Stereospecific Synthesis of the CP-263,114 Core Structure
    Chen, C.; Layton, M. E.; Shair, M. D.
    J. Am. Chem. Soc. 1998, 120, 10784–10785