The global focus of the Cardiovascular Physiology Autonomic Function Laboratory is to examine the adaptive capacity of the circulation.
We study the effects of exercise training, bed rest deconditioning, spaceflight, high altitude, aging, and the effects of cardiovascular diseases, such as heart failure.
By using sophisticated tools to assess cardiovascular structure and function, our research team brings "Olympic" and "space age" science to the solution of common clinical problems such as fainting, hypertension, or patients with shortness of breath.
We focus on measuring how the cardio-respiratory system distributes oxygen from the environment to the muscles.
Our facility is one of the few labs in the world that can measure the limitations to exercise capacity at every step along the "oxygen cascade" - including the lungs, heart and muscles.
We use invasive and non-invasive tools to assess cardiovascular structure and function, as well as circulatory control mechanisms.
The work of Deborah Carlson, Ph.D., focuses on characterizing the inflammasome mediating the inflammatory response in the heart following thermal injury and thermal injury complicated with sepsis.
Kidney disease has reached epidemic proportions in the U.S. The Carroll Lab performs basic and translational research focused on kidney development, maintenance and regeneration.
Thomas Carroll, Ph.D.
Biomedical EngineeringGenetics, Development and Disease
Castrillion Lab's work is aimed at understanding why endometrial or uterine cancers arise and spread, with an eye on prevention, earlier and more accurate diagnosis, improved treatments, and better overall patient outcomes.
Interrogating the genome to better understand the mechanisms causing autism spectrum disorder and other neurodevelopmental disorders and inform innovative therapies
Dr. Chalak’s lab focuses on improving neonatal neurologic care and outcomes for vulnerable babies through the NeuroNICU clinical program, Neonatal Neurology Fellowship, and NIH research program.
The work of the CHemical Advanced Neuroimaging lab is focused on developing state-of-the-art proton MRS and MRSI methods and leveraging these tools to answer key clinical questions and improve the quality of neurologic care.
Our lab is creating better experimental models that reveal how cancer cells metastasize and evade our immune system. We use these models to develop new drugs that engage our immune system to kill cancer cells.
We are interested in building small organic molecules and studying their functions in biological systems. Our lab started in 2004 using state-of-the-art tools to address challenging issues in the field of natural product synthesis.
Elizabeth Chen Lab focuses research on cell-cell fusion, drosophila myoblast fusion, invasive membrane protrusions, actin binding and bundling proteins, and mechanoresponsive proteins.
Elizabeth Chen, Ph.D.
cell-cell fusion
Cell and Molecular BiologyGenetics, Development and Disease
Welcome to the Reproductive Genomics Laboratory (RGL) at UT Southwestern Medical Center where we innovate at the intersection of genomics, bioengineering, and data science to answer fundamental questions in reproductive biology.
Our primary research interest is to understand the emerging roles of the “unannotated genome,” which encodes a whole new class of uncharacterized microproteins. We focus on the relevance and function of this “dark proteome” in regulating development and disease.
Chen lab studies how dysregulation of RNA synthesis and degradation drives childhood cancers with the ultimate goal of identifying new therapeutic vulnerabilities to exploit in treating them.
Jonathan Cheng's Lab performs a comprehensive suite of outcome measures to assess peripheral nerve recovery and chronic neural interfacing in the research setting.
My lab has a long-time interest in understanding the mechanisms of transcription and gene regulation in mammalian cells using initially cell-free systems reconstituted with purified gene-specific transcription factors, general cofactors, and components of the general transcription machinery to recapitulate transcriptional events in vitro.
Ascending somatosensory circuitry that shapes the perception of touch and pain. We study the development, function and dysfunction of ascending somatosensory pathways.
The Chong Research group has been conducting clinical and translational research on cutaneous lupus including outcome measure development for clinical trials, biomarkers for diagnosis and prognosis, and disease outcomes.
The Chook Lab studies physical and cellular mechanisms of Kaps. Our long-term goals are to understand how the macromolecular nuclear traffic patterns coordinated by the 20 human Kaps contribute to overall cellular organization.
We use in vivo models of ischemic acute kidney injury in mice, and in vitro model systems to perform detailed studies of proinflammatory genes activated by renal ischemia/reperfusion.
Chung Lab uses primary human specimens, patient-derived xenograft models, and genetically engineered mouse models to study the molecular mechanisms underlying disease stem cell function in hematologic malignancies.
The discovery of ANP many years ago sparked interest in the use of natriuretic peptides to diagnose and treat heart failure and other salt-retaining disorders. Since then, there have been successes and failures. A more comprehensive understanding of the natriuretic peptide system, including the role of noncardiac factors such as race/ethnicity, may encourage more targeted approaches. One of the original insights of de Bold et al, was that the heart is an endocrine organ. Endocrine therapies are administered to individuals with specific evidence of endocrine dysfunction, not to capture short-term beneficial effects. For instance, thyroid hormone is given only to patients in whom hypothyroidism is demonstrated, not based on its metabolic actions. Studies are warranted to determine whether a similar strategy for the heart’s endocrine system can advance the prevention and treatment of cardiometabolic disease. CMRU is strategically positioned to advance research toward this important strategic goal.
